Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation
Recent studies suggest ultraviolet radiation (UVR)/vitamin D is protective against the development of multiple sclerosis (MS). We determined if outcome in MS is associated with the surrogate for host pigmentation, skin type, and parameters of UVR exposure. We used a validated questionnaire to determ...
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| Veröffentlicht in: | Multiple sclerosis 2007-04, Vol.13 (3), p.369-375 |
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| creator | Woolmore, J.A. Stone, M. Pye, E.M. Partridge, J.M. Boggild, M. Young, C. Jones, P.W. Fryer, A.A. Hawkins, C.P. Strange, R.C. |
| description | Recent studies suggest ultraviolet radiation (UVR)/vitamin D is protective against the development of multiple sclerosis (MS). We determined if outcome in MS is associated with the surrogate for host pigmentation, skin type, and parameters of UVR exposure. We used a validated questionnaire to determine skin type and UVR exposure during childhood (0-16 years), and early adult life (17-40 years), in 448 Caucasians with MS. Outcome was assessed using the Kurtzke Expanded Disability Status Score (EDSS) and Multiple Sclerosis Severity Scale (MSSS). We studied the association of skin type and exposure with dichotomized values of EDSS (< and ≥6) and MSSS (continuous variable) using logistic and linear regression analyses, respectively. Sex, onset age and MS duration were significantly associated with outcome in all patients. In 169 females with established disease (≥10 years), sun sensitive skin types 1 and 2 were associated with reduced risk of EDSS ≥6 (odds ratio =0.50; 95% CI = 0.26-0.97), and higher MSSS values (coefficient = -0.86; 95% CI = -1.67 to -0.05). Parameters of UVR exposure were not significantly associated with outcome. These preliminary data show an association between skin type and disability in female MS patients. They are compatible with independent studies suggesting that exposure mediates MS pathogenesis via vitamin D. Further studies are required to properly assess these potentially important findings. Multiple Sclerosis 2007; 13: 369-375. http://msj.sagepub.com |
| doi_str_mv | 10.1177/135245850607192 |
| format | Article |
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We determined if outcome in MS is associated with the surrogate for host pigmentation, skin type, and parameters of UVR exposure. We used a validated questionnaire to determine skin type and UVR exposure during childhood (0-16 years), and early adult life (17-40 years), in 448 Caucasians with MS. Outcome was assessed using the Kurtzke Expanded Disability Status Score (EDSS) and Multiple Sclerosis Severity Scale (MSSS). We studied the association of skin type and exposure with dichotomized values of EDSS (< and ≥6) and MSSS (continuous variable) using logistic and linear regression analyses, respectively. Sex, onset age and MS duration were significantly associated with outcome in all patients. In 169 females with established disease (≥10 years), sun sensitive skin types 1 and 2 were associated with reduced risk of EDSS ≥6 (odds ratio =0.50; 95% CI = 0.26-0.97), and higher MSSS values (coefficient = -0.86; 95% CI = -1.67 to -0.05). Parameters of UVR exposure were not significantly associated with outcome. These preliminary data show an association between skin type and disability in female MS patients. They are compatible with independent studies suggesting that exposure mediates MS pathogenesis via vitamin D. Further studies are required to properly assess these potentially important findings. Multiple Sclerosis 2007; 13: 369-375. http://msj.sagepub.com</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/135245850607192</identifier><identifier>PMID: 17439906</identifier><identifier>CODEN: MUSCFZ</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Age of Onset ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disability Evaluation ; Disabled Persons ; Environmental Exposure ; Female ; Heliotherapy ; Humans ; Immunomodulators ; Male ; Medical sciences ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Pharmacology. Drug treatments ; Severity of Illness Index ; Sex Characteristics ; Skin - physiopathology ; Sunlight ; Surveys and Questionnaires ; Ultraviolet Rays</subject><ispartof>Multiple sclerosis, 2007-04, Vol.13 (3), p.369-375</ispartof><rights>2007 INIST-CNRS</rights><rights>SAGE Publications © Apr 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-e8a21da822efb68bfe5a32db94ed0ca612dc32c4fbf2a7bb121e4766132ecbcb3</citedby><cites>FETCH-LOGICAL-c304t-e8a21da822efb68bfe5a32db94ed0ca612dc32c4fbf2a7bb121e4766132ecbcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/135245850607192$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/135245850607192$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18687096$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17439906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woolmore, J.A.</creatorcontrib><creatorcontrib>Stone, M.</creatorcontrib><creatorcontrib>Pye, E.M.</creatorcontrib><creatorcontrib>Partridge, J.M.</creatorcontrib><creatorcontrib>Boggild, M.</creatorcontrib><creatorcontrib>Young, C.</creatorcontrib><creatorcontrib>Jones, P.W.</creatorcontrib><creatorcontrib>Fryer, A.A.</creatorcontrib><creatorcontrib>Hawkins, C.P.</creatorcontrib><creatorcontrib>Strange, R.C.</creatorcontrib><title>Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Recent studies suggest ultraviolet radiation (UVR)/vitamin D is protective against the development of multiple sclerosis (MS). We determined if outcome in MS is associated with the surrogate for host pigmentation, skin type, and parameters of UVR exposure. We used a validated questionnaire to determine skin type and UVR exposure during childhood (0-16 years), and early adult life (17-40 years), in 448 Caucasians with MS. Outcome was assessed using the Kurtzke Expanded Disability Status Score (EDSS) and Multiple Sclerosis Severity Scale (MSSS). We studied the association of skin type and exposure with dichotomized values of EDSS (< and ≥6) and MSSS (continuous variable) using logistic and linear regression analyses, respectively. Sex, onset age and MS duration were significantly associated with outcome in all patients. In 169 females with established disease (≥10 years), sun sensitive skin types 1 and 2 were associated with reduced risk of EDSS ≥6 (odds ratio =0.50; 95% CI = 0.26-0.97), and higher MSSS values (coefficient = -0.86; 95% CI = -1.67 to -0.05). Parameters of UVR exposure were not significantly associated with outcome. These preliminary data show an association between skin type and disability in female MS patients. They are compatible with independent studies suggesting that exposure mediates MS pathogenesis via vitamin D. Further studies are required to properly assess these potentially important findings. Multiple Sclerosis 2007; 13: 369-375. http://msj.sagepub.com</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disability Evaluation</subject><subject>Disabled Persons</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Heliotherapy</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Pharmacology. Drug treatments</subject><subject>Severity of Illness Index</subject><subject>Sex Characteristics</subject><subject>Skin - physiopathology</subject><subject>Sunlight</subject><subject>Surveys and Questionnaires</subject><subject>Ultraviolet Rays</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM1LJDEQxYPs4vfZm4QFb9Nrkv5I-ijiroLgYXfPTSWplmhP95hKK_Pfb4YZGBA8VcH71auqx9iFFD-l1PpalrWqalOLRmjZqgN2LCutC9Fq8S33WS028hE7IXoRQmhd1ofsSOqqbFvRHLPlnzT7gMSnngPR5AKkMI3ELaYPxJH7QGDDENKah5Ev5yGF1YCc3IBxokALTq9ZSOsVLvgzjh4jh9HzDEZ4D9OAiUfwW9sz9r2HgfB8V0_Zv193f2_vi8en3w-3N4-FK0WVCjSgpAejFPa2MbbHGkrlbVuhFw4aqbwrlat62yvQ1kolsdJNI0uFzjpbnrIfW99VnN5mpNS9THMc88pOSWOE1I3J0PUWcvkRith3qxiWENedFN0m3e5Tunnicmc72yX6Pb-LMwNXOwDIwdBHGF2gPWcao0W74RZbjuAZ97d9tfc_wISQ7g</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Woolmore, J.A.</creator><creator>Stone, M.</creator><creator>Pye, E.M.</creator><creator>Partridge, J.M.</creator><creator>Boggild, M.</creator><creator>Young, C.</creator><creator>Jones, P.W.</creator><creator>Fryer, A.A.</creator><creator>Hawkins, C.P.</creator><creator>Strange, R.C.</creator><general>SAGE Publications</general><general>Arnold</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200704</creationdate><title>Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation</title><author>Woolmore, J.A. ; Stone, M. ; Pye, E.M. ; Partridge, J.M. ; Boggild, M. ; Young, C. ; Jones, P.W. ; Fryer, A.A. ; Hawkins, C.P. ; Strange, R.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-e8a21da822efb68bfe5a32db94ed0ca612dc32c4fbf2a7bb121e4766132ecbcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disability Evaluation</topic><topic>Disabled Persons</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Heliotherapy</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Pharmacology. 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We determined if outcome in MS is associated with the surrogate for host pigmentation, skin type, and parameters of UVR exposure. We used a validated questionnaire to determine skin type and UVR exposure during childhood (0-16 years), and early adult life (17-40 years), in 448 Caucasians with MS. Outcome was assessed using the Kurtzke Expanded Disability Status Score (EDSS) and Multiple Sclerosis Severity Scale (MSSS). We studied the association of skin type and exposure with dichotomized values of EDSS (< and ≥6) and MSSS (continuous variable) using logistic and linear regression analyses, respectively. Sex, onset age and MS duration were significantly associated with outcome in all patients. In 169 females with established disease (≥10 years), sun sensitive skin types 1 and 2 were associated with reduced risk of EDSS ≥6 (odds ratio =0.50; 95% CI = 0.26-0.97), and higher MSSS values (coefficient = -0.86; 95% CI = -1.67 to -0.05). Parameters of UVR exposure were not significantly associated with outcome. These preliminary data show an association between skin type and disability in female MS patients. They are compatible with independent studies suggesting that exposure mediates MS pathogenesis via vitamin D. Further studies are required to properly assess these potentially important findings. Multiple Sclerosis 2007; 13: 369-375. http://msj.sagepub.com</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17439906</pmid><doi>10.1177/135245850607192</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Age of Onset Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disability Evaluation Disabled Persons Environmental Exposure Female Heliotherapy Humans Immunomodulators Male Medical sciences Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Pharmacology. Drug treatments Severity of Illness Index Sex Characteristics Skin - physiopathology Sunlight Surveys and Questionnaires Ultraviolet Rays |
| title | Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation |
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