Prion protein trafficking and the development of neurodegeneration
The prion protein (PrP) is involved in causing a group of diverse transmissible, heritable and sporadically occurring neurodegenerative diseases. Although the identity, nature and replication of the transmissible agent have been intensely studied for decades, the cellular events underlying neuronal...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2003-07, Vol.26 (7), p.337-339 |
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| container_title | Trends in neurosciences (Regular ed.) |
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| creator | Hegde, Ramanujan S. Rane, Neena S. |
| description | The prion protein (PrP) is involved in causing a group of diverse transmissible, heritable and sporadically occurring neurodegenerative diseases. Although the identity, nature and replication of the transmissible agent have been intensely studied for decades, the cellular events underlying neuronal dysfunction and death have received comparatively little attention. Recent studies examining the occurrence and consequences of inappropriate cytoplasmic expression of the normally cell-surface PrP underscore an emerging role for PrP trafficking in prion disease pathogenesis. |
| doi_str_mv | 10.1016/S0166-2236(03)00143-7 |
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Prion diseases</subject><subject>Medical sciences</subject><subject>Nerve Degeneration - metabolism</subject><subject>Neurology</subject><subject>Prions - metabolism</subject><subject>Prions - toxicity</subject><subject>Proteins</subject><subject>Signal Transduction</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMobk5_glIEQS-q-eia9kp0-AUDBRW8C2lyMjO3dCbtwH9vthV36c3JzfO-5-RB6JjgS4JJfvUaR55SyvJzzC4wJhlL-Q7qk4IXKcHFxy7q_yE9dBDCdAUVJNtHPUKLIc5o3ke3L97WLln4ugHrksZLY6z6sm6SSKeT5hMSDUuY1Ys5uCapTeKg9bWGCTjwsonhQ7Rn5CzAUfcO0Pv93dvoMR0_PzyNbsapYgVv0qrIcAVlmeWQc6lyUFSDkhhTzpXmWCpTcmOY5rLSlFAleUU0I0NeGlNVlA3Q6aY3HvvdQmjEtG69iysFjb9mtCxZhIYbSPk6BA9GLLydS_8jCBYrcWItTqysCMzEWpzgMXfSlbfVHPQ21ZmKwFkHyKDkzHjplA1bbkgLGpsjd73hIKpYWvAiKAtOgbYeVCN0bf855Rewgorv</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Hegde, Ramanujan S.</creator><creator>Rane, Neena S.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20030701</creationdate><title>Prion protein trafficking and the development of neurodegeneration</title><author>Hegde, Ramanujan S. ; Rane, Neena S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-b840be9946e67ac6ec2deca00277cd70acf97ff3d7abd212ca7b1d31579ffbb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytoplasm - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. 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| fulltext | fulltext |
| identifier | ISSN: 0166-2236 |
| ispartof | Trends in neurosciences (Regular ed.), 2003-07, Vol.26 (7), p.337-339 |
| issn | 0166-2236 1878-108X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Cytoplasm - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Medical sciences Nerve Degeneration - metabolism Neurology Prions - metabolism Prions - toxicity Proteins Signal Transduction |
| title | Prion protein trafficking and the development of neurodegeneration |
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