Choice of vincristine or 6-mercaptopurine on the basis of polyamine level in tumor-bearing regions of the brain

The effects of vincristine (VC) and 6-mercaptopurine (6-MP) on body weight, regional weights, and the contents of putrescine, spermidine, and spermine in six regions of the brain were examined in rats that had been given these drugs for 5 consecutive days. VC is recommended for management of tumors...

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Veröffentlicht in:	Cancer letters 1999-05, Vol.139 (1), p.51-58
Hauptverfasser:	Watanabe, Satoru, Sato, Shoichi, Nagase, Sumika, Shimosato, Kazuaki, Ohkuma, Seitaro
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Mercaptopurine Acids Animals Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Body weight Brain cancer Brain Neoplasms - drug therapy Brain tumors Cancer therapies Cell growth Chemotherapy Chromatography Chromatography, High Pressure Liquid Corpus striatum Diencephalon Drugs Hypothalamus Male Medical sciences Mercaptopurine - pharmacology Mercaptopurine - therapeutic use Neostriatum Pharmacology. Drug treatments Polyamine Polyamines Polyamines - analysis Potash Potassium Putrescine Putrescine - analysis Rats Rats, Sprague-Dawley Spermidine Spermidine - analysis Spermine Spermine - analysis Thalamus Tumor cells Tumors Vincristine Vincristine - pharmacology Vincristine - therapeutic use
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