Genetic Influences on the Amount of Cell Death in the Neural Tube of BXD Mice Exposed to Acute Ethanol at Midgestation

Background Fetal alcohol spectrum disorders (FASD) have a strong genetic component although the genes that underlie this are only beginning to be elucidated. In the present study, one of the most common phenotypes of FASD, cell death within the early developing neural tube, was examined across a gen...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 2019-03, Vol.43 (3), p.439-452
Hauptverfasser:	Théberge, Emilie T., Baker, Jessica A., Dubose, Candis, Boyle, Julia K., Balce, Kristina, Goldowitz, Dan, Hamre, Kristin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Exposure at Embryonic Day 9.5 Alcohol use Alcohols Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Brain stem Brain Stem - drug effects BXD Strains Cell death Chromosome 14 Chromosome 4 Dextrin Ethanol Ethanol - adverse effects Ethanol - blood Exposure FASD Female Fetal alcohol syndrome Forebrain Gene loci Gene mapping Genetic effects Genetics Homeobox Inbreeding Kinetics Maltose Mice Mice, Inbred Strains Neural tube Neural Tube - drug effects Nuclear factor I Otx2 protein Phenotypes Population genetics Pregnancy - drug effects Prosencephalon - drug effects Quantitative Trait Loci Sensitivity Species Specificity
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