Syntheses of novel modified acyclic purine and pyrimidine nucleosides as potential substrates of herpes simplex virus type-1 thymidine kinase for monitoring gene expression

Suicide gene therapy with the herpes simplex virus type-1 thymidine kinase gene (HSV-1 tk) is considered to be a promising approach to the treatment of cancer. Making use of the lower specificity of the viral enzyme compared to human thymidine kinase, the therapy involves the administration of antiv...

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Veröffentlicht in:	Canadian journal of chemistry 2004-04, Vol.82 (4), p.513-523
Hauptverfasser:	Grote, Michaela, Noll, Steffi, Noll, Bernhard, Johannsen, Bernd, Kraus, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antiviral agents Enzymatic activity Gene therapy Herpes simplex virus 1 Herpes viruses Radioactive tracers Suicide Tomography
Online-Zugang:	Volltext
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