Acute Akinesia, an unusual complication in Parkinson’s Disease: a case report
Acute akinesia (AA) is a rare but serious complication of Parkinson’s Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untrea...
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| Veröffentlicht in: | Neurological sciences 2008-06, Vol.29 (3), p.181-183 |
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| creator | Simonetto, Marco Ferigo, Laura Zanet, Luca Capus, Livio Antonutti, Lucia Zorzon, Marino Pizzolato, Gilberto |
| description | Acute akinesia (AA) is a rare but serious complication of Parkinson’s Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39°C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks. |
| doi_str_mv | 10.1007/s10072-008-0933-2 |
| format | Article |
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It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39°C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-008-0933-2</identifier><identifier>PMID: 18612768</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Acute Disease ; Aged ; Antiparkinson Agents - adverse effects ; Antiparkinson Agents - metabolism ; Apomorphine - administration & dosage ; Basal Ganglia Diseases - diagnosis ; Basal Ganglia Diseases - drug therapy ; Basal Ganglia Diseases - physiopathology ; Case Report ; Creatine Kinase - blood ; Disease Progression ; Dopamine Agonists - administration & dosage ; Drug Resistance ; Fever - chemically induced ; Fever - metabolism ; Fever - physiopathology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Ondansetron - administration & dosage ; Parkinson Disease - complications ; Parkinson's disease ; Psychiatry ; Respiratory Insufficiency ; Serotonin Antagonists - administration & dosage ; Syndrome ; Treatment Outcome</subject><ispartof>Neurological sciences, 2008-06, Vol.29 (3), p.181-183</ispartof><rights>Springer-Verlag Italia 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-ef250cc2795d9b825c617203462d9f11cc294f5d3e3509a9a520b30a68ae69bf3</citedby><cites>FETCH-LOGICAL-c412t-ef250cc2795d9b825c617203462d9f11cc294f5d3e3509a9a520b30a68ae69bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-008-0933-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-008-0933-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18612768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simonetto, Marco</creatorcontrib><creatorcontrib>Ferigo, Laura</creatorcontrib><creatorcontrib>Zanet, Luca</creatorcontrib><creatorcontrib>Capus, Livio</creatorcontrib><creatorcontrib>Antonutti, Lucia</creatorcontrib><creatorcontrib>Zorzon, Marino</creatorcontrib><creatorcontrib>Pizzolato, Gilberto</creatorcontrib><title>Acute Akinesia, an unusual complication in Parkinson’s Disease: a case report</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Acute akinesia (AA) is a rare but serious complication of Parkinson’s Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39°C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Antiparkinson Agents - adverse effects</subject><subject>Antiparkinson Agents - metabolism</subject><subject>Apomorphine - administration & dosage</subject><subject>Basal Ganglia Diseases - diagnosis</subject><subject>Basal Ganglia Diseases - drug therapy</subject><subject>Basal Ganglia Diseases - physiopathology</subject><subject>Case Report</subject><subject>Creatine Kinase - blood</subject><subject>Disease Progression</subject><subject>Dopamine Agonists - administration & dosage</subject><subject>Drug Resistance</subject><subject>Fever - chemically induced</subject><subject>Fever - metabolism</subject><subject>Fever - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Ondansetron - administration & dosage</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson's disease</subject><subject>Psychiatry</subject><subject>Respiratory Insufficiency</subject><subject>Serotonin Antagonists - administration & dosage</subject><subject>Syndrome</subject><subject>Treatment Outcome</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kL9OwzAQhy0EoqXwACzIYiZwtuPEZqvKX6lSGWC2HMdBKa0T7GRg4zV4PZ4EV4nUicVn6b77ne5D6JzANQHIb8LupQmASEAyltADNCVcQsLSXByOfyLydIJOQlgDAEkJO0YTIjJC80xM0Wpu-s7i-UftbKj1FdYO964Pvd5g02zbTW10VzcO1w6_aB-x0Ljf75-A7-pgdbC3WGMTK_a2bXx3io4qvQn2bKwz9PZw_7p4Sparx-fFfJmYlNAusRXlYAzNJS9lISg3GckpsDSjpawIiS2ZVrxklnGQWmpOoWCgM6FtJouKzdDlkNv65rO3oVPrpvcurlQ0XiekYFmEyAAZ34TgbaVaX2-1_1IE1M6dGgyqaFDtDCoaZy7G4L7Y2nI_MSqLAB2AEFvu3fr95v9T_wDn93so</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Simonetto, Marco</creator><creator>Ferigo, Laura</creator><creator>Zanet, Luca</creator><creator>Capus, Livio</creator><creator>Antonutti, Lucia</creator><creator>Zorzon, Marino</creator><creator>Pizzolato, Gilberto</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20080601</creationdate><title>Acute Akinesia, an unusual complication in Parkinson’s Disease: a case report</title><author>Simonetto, Marco ; Ferigo, Laura ; Zanet, Luca ; Capus, Livio ; Antonutti, Lucia ; Zorzon, Marino ; Pizzolato, Gilberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-ef250cc2795d9b825c617203462d9f11cc294f5d3e3509a9a520b30a68ae69bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Antiparkinson Agents - adverse effects</topic><topic>Antiparkinson Agents - metabolism</topic><topic>Apomorphine - administration & dosage</topic><topic>Basal Ganglia Diseases - diagnosis</topic><topic>Basal Ganglia Diseases - drug therapy</topic><topic>Basal Ganglia Diseases - physiopathology</topic><topic>Case Report</topic><topic>Creatine Kinase - blood</topic><topic>Disease Progression</topic><topic>Dopamine Agonists - administration & dosage</topic><topic>Drug Resistance</topic><topic>Fever - chemically induced</topic><topic>Fever - metabolism</topic><topic>Fever - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Ondansetron - administration & dosage</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson's disease</topic><topic>Psychiatry</topic><topic>Respiratory Insufficiency</topic><topic>Serotonin Antagonists - administration & dosage</topic><topic>Syndrome</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simonetto, Marco</creatorcontrib><creatorcontrib>Ferigo, Laura</creatorcontrib><creatorcontrib>Zanet, Luca</creatorcontrib><creatorcontrib>Capus, Livio</creatorcontrib><creatorcontrib>Antonutti, Lucia</creatorcontrib><creatorcontrib>Zorzon, Marino</creatorcontrib><creatorcontrib>Pizzolato, Gilberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simonetto, Marco</au><au>Ferigo, Laura</au><au>Zanet, Luca</au><au>Capus, Livio</au><au>Antonutti, Lucia</au><au>Zorzon, Marino</au><au>Pizzolato, Gilberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Akinesia, an unusual complication in Parkinson’s Disease: a case report</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>29</volume><issue>3</issue><spage>181</spage><epage>183</epage><pages>181-183</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Acute akinesia (AA) is a rare but serious complication of Parkinson’s Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39°C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>18612768</pmid><doi>10.1007/s10072-008-0933-2</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurological sciences, 2008-06, Vol.29 (3), p.181-183 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acute Disease Aged Antiparkinson Agents - adverse effects Antiparkinson Agents - metabolism Apomorphine - administration & dosage Basal Ganglia Diseases - diagnosis Basal Ganglia Diseases - drug therapy Basal Ganglia Diseases - physiopathology Case Report Creatine Kinase - blood Disease Progression Dopamine Agonists - administration & dosage Drug Resistance Fever - chemically induced Fever - metabolism Fever - physiopathology Humans Male Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Ondansetron - administration & dosage Parkinson Disease - complications Parkinson's disease Psychiatry Respiratory Insufficiency Serotonin Antagonists - administration & dosage Syndrome Treatment Outcome |
| title | Acute Akinesia, an unusual complication in Parkinson’s Disease: a case report |
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