Hidden Markov models approach to the analysis of array CGH data

The development of solid tumors is associated with acquisition of complex genetic alterations, indicating that failures in the mechanisms that maintain the integrity of the genome contribute to tumor evolution. Thus, one expects that the particular types of genomic alterations seen in tumors reflect...

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Veröffentlicht in:	Journal of multivariate analysis 2004-07, Vol.90 (1), p.132-153
Hauptverfasser:	Fridlyand, Jane, Snijders, Antoine M., Pinkel, Dan, Albertson, Donna G., Jain, Ajay N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Array CGH Cancer Chromosomal aberrations Cloning Genes Genomic profile HMM HMM Array CGH MMR Chromosomal aberrations Genomic profile Mutation Cancer Markov analysis MMR Mutation Studies Tumors
Online-Zugang:	Volltext
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