Anticonvulsant activity of gabapentin in mice - An experimental study

The effectiveness of GBP in focal seizure with/without secondary generalization[8] has led to our hypothesis to assess the anticonvulsant activity of GBP in generalized seizure. [...]the present experimental study was undertaken to evaluate the anticonvulsant activity of GBP in mice using standard models of epilepsy. RESULTS MES Model In the control group, all the six animals exhibited THE. [...]no protection was observed in them, whereas in GBP group, one of six animals exhibited THE. [...]GBP showed protection against THE in 83.34% (5/6) animals. According to Hendrich et al., GBP binds to an exofacial epitope of the a25-1 and a25-2 auxiliary subunits of voltage-gated calcium channels, but acute inhibition of calcium currents by GBP is either very minor or absent.