Efficacy of rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold
•Rapamycin was efficient in suppressing mycelial growth of B. cinerea.•Rapamycin modulated autophagic activity and membrane permeability.•Rapamycin increased membrane peroxidation and leakages of cytosolic contents. Postharvest diseases severely deteriorate the intrinsic quality and commercial value...
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| Veröffentlicht in: | Postharvest biology and technology 2019-04, Vol.150, p.158-165 |
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| container_title | Postharvest biology and technology |
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| creator | Ma, Danying Ji, Dongchao Zhang, Zhanquan Li, Boqiang Qin, Guozheng Xu, Yong Chen, Tong Tian, Shiping |
| description | •Rapamycin was efficient in suppressing mycelial growth of B. cinerea.•Rapamycin modulated autophagic activity and membrane permeability.•Rapamycin increased membrane peroxidation and leakages of cytosolic contents.
Postharvest diseases severely deteriorate the intrinsic quality and commercial value of fruits and vegetables, leading to significant economic losses for farmers and increased costs for consumers. In the present study, rapamycin was effective in suppressing mycelial growth of Botrytis cinerea and disease severity of gray mold on harvested apple, pear and grape fruits. The inhibitory mechanism was attributed to a modulation in autophagic activity and membrane permeability rather than the induction of reactive oxygen species. Increases in the degree of membrane peroxidation and the leakage of cytosolic contents were also detected, supporting the data on reduced cell viability. The results indicated that rapamycin may be a promising alternative for controlling gray mold caused by B. cinerea on harvested produce. |
| doi_str_mv | 10.1016/j.postharvbio.2019.01.005 |
| format | Article |
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Postharvest diseases severely deteriorate the intrinsic quality and commercial value of fruits and vegetables, leading to significant economic losses for farmers and increased costs for consumers. In the present study, rapamycin was effective in suppressing mycelial growth of Botrytis cinerea and disease severity of gray mold on harvested apple, pear and grape fruits. The inhibitory mechanism was attributed to a modulation in autophagic activity and membrane permeability rather than the induction of reactive oxygen species. Increases in the degree of membrane peroxidation and the leakage of cytosolic contents were also detected, supporting the data on reduced cell viability. The results indicated that rapamycin may be a promising alternative for controlling gray mold caused by B. cinerea on harvested produce.</description><identifier>ISSN: 0925-5214</identifier><identifier>EISSN: 1873-2356</identifier><identifier>DOI: 10.1016/j.postharvbio.2019.01.005</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Agricultural economics ; Autophagy ; Botrytis cinerea ; Economic impact ; Fruits ; Grey mold ; Membrane integrity ; Membrane permeability ; Mycelia ; Peroxidation ; Post-harvest decay ; Rapamycin ; Reactive oxygen species</subject><ispartof>Postharvest biology and technology, 2019-04, Vol.150, p.158-165</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright Elsevier BV Apr 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-bc61e04ed3e9006264879cfa2eb50d97f94ba2e23395fbf5687bfc73b3994d7a3</citedby><cites>FETCH-LOGICAL-c349t-bc61e04ed3e9006264879cfa2eb50d97f94ba2e23395fbf5687bfc73b3994d7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.postharvbio.2019.01.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids></links><search><creatorcontrib>Ma, Danying</creatorcontrib><creatorcontrib>Ji, Dongchao</creatorcontrib><creatorcontrib>Zhang, Zhanquan</creatorcontrib><creatorcontrib>Li, Boqiang</creatorcontrib><creatorcontrib>Qin, Guozheng</creatorcontrib><creatorcontrib>Xu, Yong</creatorcontrib><creatorcontrib>Chen, Tong</creatorcontrib><creatorcontrib>Tian, Shiping</creatorcontrib><title>Efficacy of rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold</title><title>Postharvest biology and technology</title><description>•Rapamycin was efficient in suppressing mycelial growth of B. cinerea.•Rapamycin modulated autophagic activity and membrane permeability.•Rapamycin increased membrane peroxidation and leakages of cytosolic contents.
Postharvest diseases severely deteriorate the intrinsic quality and commercial value of fruits and vegetables, leading to significant economic losses for farmers and increased costs for consumers. In the present study, rapamycin was effective in suppressing mycelial growth of Botrytis cinerea and disease severity of gray mold on harvested apple, pear and grape fruits. The inhibitory mechanism was attributed to a modulation in autophagic activity and membrane permeability rather than the induction of reactive oxygen species. Increases in the degree of membrane peroxidation and the leakage of cytosolic contents were also detected, supporting the data on reduced cell viability. The results indicated that rapamycin may be a promising alternative for controlling gray mold caused by B. cinerea on harvested produce.</description><subject>Agricultural economics</subject><subject>Autophagy</subject><subject>Botrytis cinerea</subject><subject>Economic impact</subject><subject>Fruits</subject><subject>Grey mold</subject><subject>Membrane integrity</subject><subject>Membrane permeability</subject><subject>Mycelia</subject><subject>Peroxidation</subject><subject>Post-harvest decay</subject><subject>Rapamycin</subject><subject>Reactive oxygen species</subject><issn>0925-5214</issn><issn>1873-2356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkMtKxDAUhoMoOF7eIeK6Nde2WeowXmDAja5DmiYzGTpNTdKBvr0Zx4VLIXAIfN9_OD8AdxiVGOHqYVeOPqatCofW-ZIgLEqES4T4GVjgpqYFobw6BwskCC84wewSXMW4Q5ngvFkAs7LWaaVn6C0MalT7WbsB5rf33dSr5IYNVFPy41ZtnIZKJ3dw6Qd_8inMyUWYDROMgtYHqP2Qgu_7o7cJas45fXcDLqzqo7n9ndfg83n1sXwt1u8vb8vHdaEpE6lodYUNYqajRiBUkYo1tdBWEdNy1InaCtbmD6FUcNtaXjV1a3VNWyoE62pFr8H9KXcM_msyMcmdn8KQV0qCG8ZoVXGUKXGidPAxBmPlGNxehVliJI-typ3806o8tioRlrmz7C5PrslnHJwJMmpnBm06F4xOsvPuHynfLgOI9w</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Ma, Danying</creator><creator>Ji, Dongchao</creator><creator>Zhang, Zhanquan</creator><creator>Li, Boqiang</creator><creator>Qin, Guozheng</creator><creator>Xu, Yong</creator><creator>Chen, Tong</creator><creator>Tian, Shiping</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>201904</creationdate><title>Efficacy of rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold</title><author>Ma, Danying ; Ji, Dongchao ; Zhang, Zhanquan ; Li, Boqiang ; Qin, Guozheng ; Xu, Yong ; Chen, Tong ; Tian, Shiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-bc61e04ed3e9006264879cfa2eb50d97f94ba2e23395fbf5687bfc73b3994d7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Agricultural economics</topic><topic>Autophagy</topic><topic>Botrytis cinerea</topic><topic>Economic impact</topic><topic>Fruits</topic><topic>Grey mold</topic><topic>Membrane integrity</topic><topic>Membrane permeability</topic><topic>Mycelia</topic><topic>Peroxidation</topic><topic>Post-harvest decay</topic><topic>Rapamycin</topic><topic>Reactive oxygen species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Danying</creatorcontrib><creatorcontrib>Ji, Dongchao</creatorcontrib><creatorcontrib>Zhang, Zhanquan</creatorcontrib><creatorcontrib>Li, Boqiang</creatorcontrib><creatorcontrib>Qin, Guozheng</creatorcontrib><creatorcontrib>Xu, Yong</creatorcontrib><creatorcontrib>Chen, Tong</creatorcontrib><creatorcontrib>Tian, Shiping</creatorcontrib><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Postharvest biology and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Danying</au><au>Ji, Dongchao</au><au>Zhang, Zhanquan</au><au>Li, Boqiang</au><au>Qin, Guozheng</au><au>Xu, Yong</au><au>Chen, Tong</au><au>Tian, Shiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold</atitle><jtitle>Postharvest biology and technology</jtitle><date>2019-04</date><risdate>2019</risdate><volume>150</volume><spage>158</spage><epage>165</epage><pages>158-165</pages><issn>0925-5214</issn><eissn>1873-2356</eissn><abstract>•Rapamycin was efficient in suppressing mycelial growth of B. cinerea.•Rapamycin modulated autophagic activity and membrane permeability.•Rapamycin increased membrane peroxidation and leakages of cytosolic contents.
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| issn | 0925-5214 1873-2356 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Agricultural economics Autophagy Botrytis cinerea Economic impact Fruits Grey mold Membrane integrity Membrane permeability Mycelia Peroxidation Post-harvest decay Rapamycin Reactive oxygen species |
| title | Efficacy of rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold |
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