A reappraisal of the significance of largest basal diameter of posterior uveal melanoma
Objectives To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality. Methods Patients with posterior uveal melanoma were included. LTD was measured by ec...
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| Veröffentlicht in: | Eye (London) 2009-12, Vol.23 (12), p.2152-2162 |
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| creator | Damato, B Coupland, S E |
| description | Objectives
To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality.
Methods
Patients with posterior uveal melanoma were included. LTD was measured by echography and correlated with histological and cytogenetic findings and metastatic death.
Results
The cohort comprised 1776 patients with a median age of 60 years, a median tumour diameter of 14.0 mm, and a median tumour height of 7.5 mm. The LTD was greater in older patients (
t
-test,
P |
| doi_str_mv | 10.1038/eye.2009.235 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_218413017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1919200801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c330t-9221456f644c697ba31616bacde5fa6f775d95a19c987bf8f8524b5f566278253</originalsourceid><addsrcrecordid>eNptkE1LAzEURYMoWKs7f8AguHNqvjOzLMWqUHCj6C68SZOaMl8mU6H_3gwtunGVkHty3-MgdE3wjGBW3Nu9nVGMyxll4gRNCFcyF1zwUzTBpcA5pfTjHF3EuMU4hQpP0Ps8Cxb6PoCPUGedy4ZPm0W_ab3zBlpjx7cawsbGIatghNYeGjvYMCZ9F9PNdyHbfduUNbaGtmvgEp05qKO9Op5T9LZ8eF085auXx-fFfJUbxvCQl5QSLqSTnBtZqgoYkURWYNZWOJBOKbEuBZDSlIWqXOEKQXklnJCSqoIKNkU3h94-dF-7tKPedrvQppGakoITholK0N0BMqGLMVin--AbCHtNsB7N6WROj-Z0Mpfw22MnRAO1C0mDj79_kkUlmJKJyw9cTFG7seFv9r-9Pz7JfME</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218413017</pqid></control><display><type>article</type><title>A reappraisal of the significance of largest basal diameter of posterior uveal melanoma</title><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Damato, B ; Coupland, S E</creator><creatorcontrib>Damato, B ; Coupland, S E</creatorcontrib><description>Objectives
To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality.
Methods
Patients with posterior uveal melanoma were included. LTD was measured by echography and correlated with histological and cytogenetic findings and metastatic death.
Results
The cohort comprised 1776 patients with a median age of 60 years, a median tumour diameter of 14.0 mm, and a median tumour height of 7.5 mm. The LTD was greater in older patients (
t
-test,
P
<0.001). The presence of epithelioid cells, closed loops, high mitotic rate, chromosome 3 deletion, and chromosome 8 gains all correlated significantly with LTD (
t
-test,
P
<0.001). The 1521 British patients had a median follow-up of 4.9 years, with a disease-specific mortality of 28.9%. Metastatic death correlated with LTD (Cox multivariate analysis,
P
<0.001). Tumours with the same LTD showed significant variation in survival, according to the presence of epithelioid cells (Log rank,
P
<0.001), closed loops (Log rank,
P
=0.002), high mitotic rate (Log rank,
P
=0.003), and chromosome 3 loss (Log rank,
P
=0.008).
Conclusions
The value of LTD as a predictor of survival after treatment of posterior uveal melanoma is enhanced by taking histological and cytogenetic factors into account.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2009.235</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; clinical-study ; Laboratory Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Miscellaneous ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Surgery ; Surgical Oncology ; Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><ispartof>Eye (London), 2009-12, Vol.23 (12), p.2152-2162</ispartof><rights>Royal College of Ophthalmologists 2009</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Dec 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-9221456f644c697ba31616bacde5fa6f775d95a19c987bf8f8524b5f566278253</citedby><cites>FETCH-LOGICAL-c330t-9221456f644c697ba31616bacde5fa6f775d95a19c987bf8f8524b5f566278253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/eye.2009.235$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/eye.2009.235$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22275376$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Damato, B</creatorcontrib><creatorcontrib>Coupland, S E</creatorcontrib><title>A reappraisal of the significance of largest basal diameter of posterior uveal melanoma</title><title>Eye (London)</title><addtitle>Eye</addtitle><description>Objectives
To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality.
Methods
Patients with posterior uveal melanoma were included. LTD was measured by echography and correlated with histological and cytogenetic findings and metastatic death.
Results
The cohort comprised 1776 patients with a median age of 60 years, a median tumour diameter of 14.0 mm, and a median tumour height of 7.5 mm. The LTD was greater in older patients (
t
-test,
P
<0.001). The presence of epithelioid cells, closed loops, high mitotic rate, chromosome 3 deletion, and chromosome 8 gains all correlated significantly with LTD (
t
-test,
P
<0.001). The 1521 British patients had a median follow-up of 4.9 years, with a disease-specific mortality of 28.9%. Metastatic death correlated with LTD (Cox multivariate analysis,
P
<0.001). Tumours with the same LTD showed significant variation in survival, according to the presence of epithelioid cells (Log rank,
P
<0.001), closed loops (Log rank,
P
=0.002), high mitotic rate (Log rank,
P
=0.003), and chromosome 3 loss (Log rank,
P
=0.008).
Conclusions
The value of LTD as a predictor of survival after treatment of posterior uveal melanoma is enhanced by taking histological and cytogenetic factors into account.</description><subject>Biological and medical sciences</subject><subject>clinical-study</subject><subject>Laboratory Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkE1LAzEURYMoWKs7f8AguHNqvjOzLMWqUHCj6C68SZOaMl8mU6H_3gwtunGVkHty3-MgdE3wjGBW3Nu9nVGMyxll4gRNCFcyF1zwUzTBpcA5pfTjHF3EuMU4hQpP0Ps8Cxb6PoCPUGedy4ZPm0W_ab3zBlpjx7cawsbGIatghNYeGjvYMCZ9F9PNdyHbfduUNbaGtmvgEp05qKO9Op5T9LZ8eF085auXx-fFfJUbxvCQl5QSLqSTnBtZqgoYkURWYNZWOJBOKbEuBZDSlIWqXOEKQXklnJCSqoIKNkU3h94-dF-7tKPedrvQppGakoITholK0N0BMqGLMVin--AbCHtNsB7N6WROj-Z0Mpfw22MnRAO1C0mDj79_kkUlmJKJyw9cTFG7seFv9r-9Pz7JfME</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Damato, B</creator><creator>Coupland, S E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20091201</creationdate><title>A reappraisal of the significance of largest basal diameter of posterior uveal melanoma</title><author>Damato, B ; Coupland, S E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-9221456f644c697ba31616bacde5fa6f775d95a19c987bf8f8524b5f566278253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>clinical-study</topic><topic>Laboratory Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Damato, B</creatorcontrib><creatorcontrib>Coupland, S E</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Damato, B</au><au>Coupland, S E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A reappraisal of the significance of largest basal diameter of posterior uveal melanoma</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><date>2009-12-01</date><risdate>2009</risdate><volume>23</volume><issue>12</issue><spage>2152</spage><epage>2162</epage><pages>2152-2162</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>Objectives
To evaluate the significance of the largest tumour diameter (LTD) of posterior uveal melanomas (ie, involving choroid), correlating this feature with histological and cytogenetic predictors and mortality.
Methods
Patients with posterior uveal melanoma were included. LTD was measured by echography and correlated with histological and cytogenetic findings and metastatic death.
Results
The cohort comprised 1776 patients with a median age of 60 years, a median tumour diameter of 14.0 mm, and a median tumour height of 7.5 mm. The LTD was greater in older patients (
t
-test,
P
<0.001). The presence of epithelioid cells, closed loops, high mitotic rate, chromosome 3 deletion, and chromosome 8 gains all correlated significantly with LTD (
t
-test,
P
<0.001). The 1521 British patients had a median follow-up of 4.9 years, with a disease-specific mortality of 28.9%. Metastatic death correlated with LTD (Cox multivariate analysis,
P
<0.001). Tumours with the same LTD showed significant variation in survival, according to the presence of epithelioid cells (Log rank,
P
<0.001), closed loops (Log rank,
P
=0.002), high mitotic rate (Log rank,
P
=0.003), and chromosome 3 loss (Log rank,
P
=0.008).
Conclusions
The value of LTD as a predictor of survival after treatment of posterior uveal melanoma is enhanced by taking histological and cytogenetic factors into account.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/eye.2009.235</doi><tpages>11</tpages></addata></record> |
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| source | Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences clinical-study Laboratory Medicine Medical sciences Medicine Medicine & Public Health Miscellaneous Ophthalmology Pharmaceutical Sciences/Technology Surgery Surgical Oncology Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus |
| title | A reappraisal of the significance of largest basal diameter of posterior uveal melanoma |
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