Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects

Calcium‐activated chloride channels (CaCCs) are ion channels with key roles in physiological processes. They are abnormally expressed in various cancers, including esophageal squamous cell cancer, head and neck squamous cell carcinoma, colorectal cancer, and gastrointestinal stromal tumors. The CaCC...

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Veröffentlicht in:	Journal of cellular physiology 2019-06, Vol.234 (6), p.8698-8708
Hauptverfasser:	Guo, Shuai, Chen, Yafei, Pang, Chunli, Wang, Xuzhao, Shi, Sai, Zhang, Hailin, An, Hailong, Zhan, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Alkaloids - pharmacology Amino acids Animals Anoctamin-1 - antagonists & inhibitors Anoctamin-1 - genetics Anoctamin-1 - metabolism Antineoplastic Agents - pharmacology Body weight Calcium channels Calcium chloride Cancer Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Chloride channels (calcium-gated) Chloride ions Colorectal carcinoma Dose-Response Relationship, Drug Esophagus Experiments Gastrointestinal cancer Head & neck cancer HeLa Cells Humans Inhibitors Ion channels lung adenocarcinoma Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lungs matrine Mice, Inbred BALB C migration Mutation Neoplasm Invasiveness proliferation Proteins Quinolizines - pharmacology Signal Transduction Squamous cell carcinoma TMEM16A inhibitor Tumor Burden - drug effects Tumors Wound healing Xenografts Xenotransplantation
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