The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad range of exogenous chemicals and by-products of endogenous metabolism, and also controls the levels and distributi...

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Veröffentlicht in:	Physiological reviews 2019-04, Vol.99 (2), p.1153-1222
Hauptverfasser:	Meech, Robyn, Hu, Dong Gui, McKinnon, Ross A, Mubarokah, Siti Nurul, Haines, Alex Z, Nair, Pramod C, Rowland, Andrew, Mackenzie, Peter I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotransformation Cancer Detoxification Drug metabolism Enzymes Gene Expression Regulation, Enzymologic - physiology Glycosyltransferase Glycosyltransferases - classification Intestine Lipophilic Liver Mammals - metabolism Metabolism Multigene Family Post-transcription Signal transduction Signal Transduction - physiology Sugar
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