Excimer laser trabeculotomy vs 180° selective laser trabeculoplasty in primary open-angle glaucoma. A 2-year randomized, controlled trial
Purpose To compare the effectiveness and safety of excimer laser trabeculotomy (ELT) ab interno vs selective laser trabeculoplasty (SLT) over 24 months of follow-up in patients with primary open-angle glaucoma (POAG) refractory to medical therapy. Patients and methods This prospective, randomized st...
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| description | Purpose
To compare the effectiveness and safety of excimer laser trabeculotomy (ELT)
ab interno vs
selective laser trabeculoplasty (SLT) over 24 months of follow-up in patients with primary open-angle glaucoma (POAG) refractory to medical therapy.
Patients and methods
This prospective, randomized study included 30 consecutive eyes assigned randomly to either ELT or SLT group. ELT was carried out using a XeCl Excimer Laser with an emission wavelength of 308 nm. Eight spots were equally distributed at a distance of 500
μ
m from one another over the anterior trabeculum. The SLT patients were treated with a frequency-doubled q-switched neodymium : yytrium–aluminum–garnet laser (wavelength 532 nm). Approximately 50 adjacent, but not overlapping, laser spots were distributed over 180° of the trabecular meshwork, using an energy level ranging from 0.7 to 1.0 mJ per pulse. The main outcome measure was intraocular pressure (IOP) lowering after ELT and SLT. Success was defined as ⩾20% reduction in IOP without further glaucoma intervention.
Results
At 24 months, complete success rates were 53.3% for the ELT group and 40% for the SLT group (
P
=0.35, Fisher's exact test); qualified success rates were 33.3% for the ELT and 26.6% for the SLT group (
P
=0.5, Fisher's exact test).Mean IOP decreased from 25.0±1.9 to 17.6±2.2 mmHg (−29.6%;
P |
| doi_str_mv | 10.1038/eye.2009.172 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_218354696</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2009627761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2832-2793a70012c491ed6f60cf1dd69824233242cbb773db14e777368756cd187e5d3</originalsourceid><addsrcrecordid>eNptkN9KwzAUxoMoOKd3PkAQvFtnkrZJeznG_AMDbxS8K1lyOjrSpibtsD6CT-Mz-GRmbCiINycnnO_8Dt-H0CUlU0ri7AYGmDJC8ikV7AiNaCJ4lCZpcoxGJE9JxBh7OUVn3m8ICUNBRuhj8aaqGhw20ofaObkC1Rvb2XrAW49pRr4-sQcDqqu28FfWhn834KrBratq6QZsW2gi2awN4LWRvbK1nOIZZtEA0mEnG23r6h30BCvbdM4aAzrwKmnO0UkpjYeLwztGz7eLp_l9tHy8e5jPlpFiWcwiJvJYimCAqSSnoHnJiSqp1jzPWMLiOBS1WgkR6xVNQISGZyLlStNMQKrjMbrac1tnX3vwXbGxvWvCyYLRLE4TnvMgmuxFylnvHZTFwWBBSbELuwhhF7uwixB2kF8fmNIracrgU1X-Z4cxnqWC7bDRXufDqFmD-739L_cb6smPyA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218354696</pqid></control><display><type>article</type><title>Excimer laser trabeculotomy vs 180° selective laser trabeculoplasty in primary open-angle glaucoma. A 2-year randomized, controlled trial</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><creator>Babighian, S ; Caretti, L ; Tavolato, M ; Cian, R ; Galan, A</creator><creatorcontrib>Babighian, S ; Caretti, L ; Tavolato, M ; Cian, R ; Galan, A</creatorcontrib><description>Purpose
To compare the effectiveness and safety of excimer laser trabeculotomy (ELT)
ab interno vs
selective laser trabeculoplasty (SLT) over 24 months of follow-up in patients with primary open-angle glaucoma (POAG) refractory to medical therapy.
Patients and methods
This prospective, randomized study included 30 consecutive eyes assigned randomly to either ELT or SLT group. ELT was carried out using a XeCl Excimer Laser with an emission wavelength of 308 nm. Eight spots were equally distributed at a distance of 500
μ
m from one another over the anterior trabeculum. The SLT patients were treated with a frequency-doubled q-switched neodymium : yytrium–aluminum–garnet laser (wavelength 532 nm). Approximately 50 adjacent, but not overlapping, laser spots were distributed over 180° of the trabecular meshwork, using an energy level ranging from 0.7 to 1.0 mJ per pulse. The main outcome measure was intraocular pressure (IOP) lowering after ELT and SLT. Success was defined as ⩾20% reduction in IOP without further glaucoma intervention.
Results
At 24 months, complete success rates were 53.3% for the ELT group and 40% for the SLT group (
P
=0.35, Fisher's exact test); qualified success rates were 33.3% for the ELT and 26.6% for the SLT group (
P
=0.5, Fisher's exact test).Mean IOP decreased from 25.0±1.9 to 17.6±2.2 mmHg (−29.6%;
P
<0.0001) in the ELT group and from 23.9±0.9 to 19.1±1.8 mmHg (−21%;
P
<0.0001) in the SLT group.
Conclusions
Both ELT and SLT proved to be effective techniques in the treatment of POAG refractory to medical therapy.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2009.172</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; clinical-study ; Glaucoma ; Glaucoma and intraocular pressure ; Laboratory Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Miscellaneous ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Surgery ; Surgical Oncology</subject><ispartof>Eye (London), 2010, Vol.24 (4), p.632-638</ispartof><rights>Royal College of Ophthalmologists 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2832-2793a70012c491ed6f60cf1dd69824233242cbb773db14e777368756cd187e5d3</citedby><cites>FETCH-LOGICAL-c2832-2793a70012c491ed6f60cf1dd69824233242cbb773db14e777368756cd187e5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/eye.2009.172$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/eye.2009.172$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22685726$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Babighian, S</creatorcontrib><creatorcontrib>Caretti, L</creatorcontrib><creatorcontrib>Tavolato, M</creatorcontrib><creatorcontrib>Cian, R</creatorcontrib><creatorcontrib>Galan, A</creatorcontrib><title>Excimer laser trabeculotomy vs 180° selective laser trabeculoplasty in primary open-angle glaucoma. A 2-year randomized, controlled trial</title><title>Eye (London)</title><addtitle>Eye</addtitle><description>Purpose
To compare the effectiveness and safety of excimer laser trabeculotomy (ELT)
ab interno vs
selective laser trabeculoplasty (SLT) over 24 months of follow-up in patients with primary open-angle glaucoma (POAG) refractory to medical therapy.
Patients and methods
This prospective, randomized study included 30 consecutive eyes assigned randomly to either ELT or SLT group. ELT was carried out using a XeCl Excimer Laser with an emission wavelength of 308 nm. Eight spots were equally distributed at a distance of 500
μ
m from one another over the anterior trabeculum. The SLT patients were treated with a frequency-doubled q-switched neodymium : yytrium–aluminum–garnet laser (wavelength 532 nm). Approximately 50 adjacent, but not overlapping, laser spots were distributed over 180° of the trabecular meshwork, using an energy level ranging from 0.7 to 1.0 mJ per pulse. The main outcome measure was intraocular pressure (IOP) lowering after ELT and SLT. Success was defined as ⩾20% reduction in IOP without further glaucoma intervention.
Results
At 24 months, complete success rates were 53.3% for the ELT group and 40% for the SLT group (
P
=0.35, Fisher's exact test); qualified success rates were 33.3% for the ELT and 26.6% for the SLT group (
P
=0.5, Fisher's exact test).Mean IOP decreased from 25.0±1.9 to 17.6±2.2 mmHg (−29.6%;
P
<0.0001) in the ELT group and from 23.9±0.9 to 19.1±1.8 mmHg (−21%;
P
<0.0001) in the SLT group.
Conclusions
Both ELT and SLT proved to be effective techniques in the treatment of POAG refractory to medical therapy.</description><subject>Biological and medical sciences</subject><subject>clinical-study</subject><subject>Glaucoma</subject><subject>Glaucoma and intraocular pressure</subject><subject>Laboratory Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkN9KwzAUxoMoOKd3PkAQvFtnkrZJeznG_AMDbxS8K1lyOjrSpibtsD6CT-Mz-GRmbCiINycnnO_8Dt-H0CUlU0ri7AYGmDJC8ikV7AiNaCJ4lCZpcoxGJE9JxBh7OUVn3m8ICUNBRuhj8aaqGhw20ofaObkC1Rvb2XrAW49pRr4-sQcDqqu28FfWhn834KrBratq6QZsW2gi2awN4LWRvbK1nOIZZtEA0mEnG23r6h30BCvbdM4aAzrwKmnO0UkpjYeLwztGz7eLp_l9tHy8e5jPlpFiWcwiJvJYimCAqSSnoHnJiSqp1jzPWMLiOBS1WgkR6xVNQISGZyLlStNMQKrjMbrac1tnX3vwXbGxvWvCyYLRLE4TnvMgmuxFylnvHZTFwWBBSbELuwhhF7uwixB2kF8fmNIracrgU1X-Z4cxnqWC7bDRXufDqFmD-739L_cb6smPyA</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Babighian, S</creator><creator>Caretti, L</creator><creator>Tavolato, M</creator><creator>Cian, R</creator><creator>Galan, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>2010</creationdate><title>Excimer laser trabeculotomy vs 180° selective laser trabeculoplasty in primary open-angle glaucoma. A 2-year randomized, controlled trial</title><author>Babighian, S ; Caretti, L ; Tavolato, M ; Cian, R ; Galan, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2832-2793a70012c491ed6f60cf1dd69824233242cbb773db14e777368756cd187e5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>clinical-study</topic><topic>Glaucoma</topic><topic>Glaucoma and intraocular pressure</topic><topic>Laboratory Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babighian, S</creatorcontrib><creatorcontrib>Caretti, L</creatorcontrib><creatorcontrib>Tavolato, M</creatorcontrib><creatorcontrib>Cian, R</creatorcontrib><creatorcontrib>Galan, A</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babighian, S</au><au>Caretti, L</au><au>Tavolato, M</au><au>Cian, R</au><au>Galan, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excimer laser trabeculotomy vs 180° selective laser trabeculoplasty in primary open-angle glaucoma. A 2-year randomized, controlled trial</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><date>2010</date><risdate>2010</risdate><volume>24</volume><issue>4</issue><spage>632</spage><epage>638</epage><pages>632-638</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>Purpose
To compare the effectiveness and safety of excimer laser trabeculotomy (ELT)
ab interno vs
selective laser trabeculoplasty (SLT) over 24 months of follow-up in patients with primary open-angle glaucoma (POAG) refractory to medical therapy.
Patients and methods
This prospective, randomized study included 30 consecutive eyes assigned randomly to either ELT or SLT group. ELT was carried out using a XeCl Excimer Laser with an emission wavelength of 308 nm. Eight spots were equally distributed at a distance of 500
μ
m from one another over the anterior trabeculum. The SLT patients were treated with a frequency-doubled q-switched neodymium : yytrium–aluminum–garnet laser (wavelength 532 nm). Approximately 50 adjacent, but not overlapping, laser spots were distributed over 180° of the trabecular meshwork, using an energy level ranging from 0.7 to 1.0 mJ per pulse. The main outcome measure was intraocular pressure (IOP) lowering after ELT and SLT. Success was defined as ⩾20% reduction in IOP without further glaucoma intervention.
Results
At 24 months, complete success rates were 53.3% for the ELT group and 40% for the SLT group (
P
=0.35, Fisher's exact test); qualified success rates were 33.3% for the ELT and 26.6% for the SLT group (
P
=0.5, Fisher's exact test).Mean IOP decreased from 25.0±1.9 to 17.6±2.2 mmHg (−29.6%;
P
<0.0001) in the ELT group and from 23.9±0.9 to 19.1±1.8 mmHg (−21%;
P
<0.0001) in the SLT group.
Conclusions
Both ELT and SLT proved to be effective techniques in the treatment of POAG refractory to medical therapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/eye.2009.172</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Eye (London), 2010, Vol.24 (4), p.632-638 |
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| language | eng |
| recordid | cdi_proquest_journals_218354696 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences clinical-study Glaucoma Glaucoma and intraocular pressure Laboratory Medicine Medical sciences Medicine Medicine & Public Health Miscellaneous Ophthalmology Pharmaceutical Sciences/Technology Surgery Surgical Oncology |
| title | Excimer laser trabeculotomy vs 180° selective laser trabeculoplasty in primary open-angle glaucoma. A 2-year randomized, controlled trial |
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