FOXD2‐AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma
Long noncoding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2‐AS1) has been shown to be dysregulated in several types of human cancer. However, the role of FOXD2‐AS1 in cutaneous melanoma was still unclear. In our study, FOXD2‐AS1 expression has been found to be upregulated in cutaneous me...
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| Veröffentlicht in: | Journal of cellular biochemistry 2019-04, Vol.120 (4), p.5417-5423 |
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| description | Long noncoding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2‐AS1) has been shown to be dysregulated in several types of human cancer. However, the role of FOXD2‐AS1 in cutaneous melanoma was still unclear. In our study, FOXD2‐AS1 expression has been found to be upregulated in cutaneous melanoma tissue specimens and cell lines compared with that in normal tissue specimens and normal human epidermal melanocyte, respectively. Furthermore, high expression of FOXD2‐AS1 was obviously correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. However, there were no statistical associations between FOXD2‐AS1 expression and cutaneous melanoma patients’ disease‐free survival and overall survival. The results of loss‐of‐function study showed that inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression. In conclusion, FOXD2‐AS1 is associated with clinical progression in cutaneous melanoma patients, and functions as oncogenic lncRNA in cutaneous melanoma cells.
FOXD2‐AS1 overexpression is observed in cutaneous melanoma tissues and cell lines, and correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. Inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression. |
| doi_str_mv | 10.1002/jcb.27820 |
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FOXD2‐AS1 overexpression is observed in cutaneous melanoma tissues and cell lines, and correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. Inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.27820</identifier><identifier>PMID: 30426532</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aged ; AKT protein ; biomarker ; Biomarkers, Tumor - genetics ; Cancer ; Carcinogenesis - genetics ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell Movement - genetics ; Cell proliferation ; Cell Proliferation - genetics ; Disease Progression ; Disease-Free Survival ; Female ; FOXD2‐AS1 ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; lncRNA ; Male ; Melanoma ; Melanoma - genetics ; Melanoma - pathology ; Melanoma, Cutaneous Malignant ; Metastases ; Middle Aged ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; Patients ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; Signal Transduction - genetics ; Skin Neoplasms - genetics ; Skin Neoplasms - pathology ; Survival ; Tissues</subject><ispartof>Journal of cellular biochemistry, 2019-04, Vol.120 (4), p.5417-5423</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-f92823b3a230733badebf2e9ae3f023a97396cbb019bdc72bbe76af083b86aea3</citedby><cites>FETCH-LOGICAL-c3530-f92823b3a230733badebf2e9ae3f023a97396cbb019bdc72bbe76af083b86aea3</cites><orcidid>0000-0002-2867-0343</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.27820$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.27820$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30426532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Wenqing</creatorcontrib><creatorcontrib>Zhu, Zirong</creatorcontrib><creatorcontrib>Wu, Lina</creatorcontrib><title>FOXD2‐AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma</title><title>Journal of cellular biochemistry</title><addtitle>J Cell Biochem</addtitle><description>Long noncoding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2‐AS1) has been shown to be dysregulated in several types of human cancer. However, the role of FOXD2‐AS1 in cutaneous melanoma was still unclear. In our study, FOXD2‐AS1 expression has been found to be upregulated in cutaneous melanoma tissue specimens and cell lines compared with that in normal tissue specimens and normal human epidermal melanocyte, respectively. Furthermore, high expression of FOXD2‐AS1 was obviously correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. However, there were no statistical associations between FOXD2‐AS1 expression and cutaneous melanoma patients’ disease‐free survival and overall survival. The results of loss‐of‐function study showed that inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression. In conclusion, FOXD2‐AS1 is associated with clinical progression in cutaneous melanoma patients, and functions as oncogenic lncRNA in cutaneous melanoma cells.
FOXD2‐AS1 overexpression is observed in cutaneous melanoma tissues and cell lines, and correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. Inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression.</description><subject>Aged</subject><subject>AKT protein</subject><subject>biomarker</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer</subject><subject>Carcinogenesis - genetics</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - genetics</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Disease Progression</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>FOXD2‐AS1</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>lncRNA</subject><subject>Male</subject><subject>Melanoma</subject><subject>Melanoma - genetics</subject><subject>Melanoma - pathology</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Patients</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Signal Transduction - genetics</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - pathology</subject><subject>Survival</subject><subject>Tissues</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlOwzAQhi0EomU58ALIEickAs44zXKEsguJAyBxi8bJpE2VpdgOVW99BJ6RJ8GQwo3TzEif_pn5GDvwxakvBJzNMnUKUQxigw19kUReEAbBJhuKSAoPpA8DtmPMTAiRJBK22UCKAMKRhCFbXT--XsLn6uP8yedZqzVVaMnwRWmn3E6J11iVkwYby41F2xmOTc41Tbqey6iq-Fy3VVmQRlu2zQmvy8lv-w2XzTsaN7mGZ53FhloXU7tFTVvjHtsqsDK0v6677OX66nl86z083tyNzx-8TI7cF0UCMUglEaT7SirMSRVACZIsBEhMIpmEmVLCT1SeRaAURSEWIpYqDpFQ7rKjPtcd-9aRsems7XTjVqbgx1I4IyNw1HFPZbo1RlORznVZo16mvki_XafOdfrj2rGH68RO1ZT_kb9yHXDWA4uyouX_Sen9-KKP_AJb2orT</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Ren, Wenqing</creator><creator>Zhu, Zirong</creator><creator>Wu, Lina</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-2867-0343</orcidid></search><sort><creationdate>201904</creationdate><title>FOXD2‐AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma</title><author>Ren, Wenqing ; Zhu, Zirong ; Wu, Lina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-f92823b3a230733badebf2e9ae3f023a97396cbb019bdc72bbe76af083b86aea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>AKT protein</topic><topic>biomarker</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer</topic><topic>Carcinogenesis - genetics</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - genetics</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - genetics</topic><topic>Disease Progression</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>FOXD2‐AS1</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>lncRNA</topic><topic>Male</topic><topic>Melanoma</topic><topic>Melanoma - genetics</topic><topic>Melanoma - pathology</topic><topic>Melanoma, Cutaneous Malignant</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Patients</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Signal Transduction - genetics</topic><topic>Skin Neoplasms - genetics</topic><topic>Skin Neoplasms - pathology</topic><topic>Survival</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Wenqing</creatorcontrib><creatorcontrib>Zhu, Zirong</creatorcontrib><creatorcontrib>Wu, Lina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Wenqing</au><au>Zhu, Zirong</au><au>Wu, Lina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FOXD2‐AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J Cell Biochem</addtitle><date>2019-04</date><risdate>2019</risdate><volume>120</volume><issue>4</issue><spage>5417</spage><epage>5423</epage><pages>5417-5423</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>Long noncoding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2‐AS1) has been shown to be dysregulated in several types of human cancer. However, the role of FOXD2‐AS1 in cutaneous melanoma was still unclear. In our study, FOXD2‐AS1 expression has been found to be upregulated in cutaneous melanoma tissue specimens and cell lines compared with that in normal tissue specimens and normal human epidermal melanocyte, respectively. Furthermore, high expression of FOXD2‐AS1 was obviously correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. However, there were no statistical associations between FOXD2‐AS1 expression and cutaneous melanoma patients’ disease‐free survival and overall survival. The results of loss‐of‐function study showed that inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression. In conclusion, FOXD2‐AS1 is associated with clinical progression in cutaneous melanoma patients, and functions as oncogenic lncRNA in cutaneous melanoma cells.
FOXD2‐AS1 overexpression is observed in cutaneous melanoma tissues and cell lines, and correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. Inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30426532</pmid><doi>10.1002/jcb.27820</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2867-0343</orcidid></addata></record> |
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| subjects | Aged AKT protein biomarker Biomarkers, Tumor - genetics Cancer Carcinogenesis - genetics Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Disease Progression Disease-Free Survival Female FOXD2‐AS1 Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate lncRNA Male Melanoma Melanoma - genetics Melanoma - pathology Melanoma, Cutaneous Malignant Metastases Middle Aged Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Patients Ribonucleic acid RNA RNA, Long Noncoding - genetics Signal Transduction - genetics Skin Neoplasms - genetics Skin Neoplasms - pathology Survival Tissues |
| title | FOXD2‐AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma |
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