Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children
More than 25% of the world’s population is affected by anemia, of which more than 50% suffers from iron deficiency anemia (IDA). Children below 7 years of age are the population group that is most vulnerable to iron deficiency. Iron is an essential element in brain metabolism. Iron deficiency can ca...
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| Veröffentlicht in: | Journal of molecular neuroscience 2019-05, Vol.68 (1), p.1-10 |
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| description | More than 25% of the world’s population is affected by anemia, of which more than 50% suffers from iron deficiency anemia (IDA). Children below 7 years of age are the population group that is most vulnerable to iron deficiency. Iron is an essential element in brain metabolism. Iron deficiency can cause changes in neurotransmitter homeostasis, decrease myelin production, impair synaptogenesis, and decline the function of the basal ganglia. Therefore, IDA adversely affects cognitive functions and psychomotor development. Research has shown that iron deficiency is a frequent comorbidity in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder. Iron deficiency may also induce or exacerbate deficiency of other essential nutrients, which may have a negative impact on the developing brain and other organs in infants. Many nations of the world have programs to control IDA based on the use of iron supplementation, intake of fortified food and drinks, improved food safety, and monitoring of dietary diversity. Based on the current recommendations of the World Health Organization on cost-effectiveness (WHO-CHOICE), iron fortification and iron supplementation programs can be considered cost-effective or even highly cost-effective in most countries of the world to averting cognitive impairment. |
| doi_str_mv | 10.1007/s12031-019-01276-1 |
| format | Article |
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Children below 7 years of age are the population group that is most vulnerable to iron deficiency. Iron is an essential element in brain metabolism. Iron deficiency can cause changes in neurotransmitter homeostasis, decrease myelin production, impair synaptogenesis, and decline the function of the basal ganglia. Therefore, IDA adversely affects cognitive functions and psychomotor development. Research has shown that iron deficiency is a frequent comorbidity in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder. Iron deficiency may also induce or exacerbate deficiency of other essential nutrients, which may have a negative impact on the developing brain and other organs in infants. Many nations of the world have programs to control IDA based on the use of iron supplementation, intake of fortified food and drinks, improved food safety, and monitoring of dietary diversity. Based on the current recommendations of the World Health Organization on cost-effectiveness (WHO-CHOICE), iron fortification and iron supplementation programs can be considered cost-effective or even highly cost-effective in most countries of the world to averting cognitive impairment.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-019-01276-1</identifier><identifier>PMID: 30778834</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anemia ; Anemia, Iron-Deficiency - complications ; Anemia, Iron-Deficiency - epidemiology ; Anemia, Iron-Deficiency - physiopathology ; Attention deficit hyperactivity disorder ; Autism ; Basal ganglia ; Beverages ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Child ; Child Behavior ; Children ; Cognition ; Cognitive ability ; Cost of Illness ; Developmental Disabilities - epidemiology ; Developmental Disabilities - etiology ; Diet ; Dietary supplements ; Essential nutrients ; Food ; Food intake ; Food safety ; Ganglia ; Homeostasis ; Humans ; Hyperactivity ; Infants ; Iron ; Iron deficiency ; Metabolism ; Myelin ; Neurochemistry ; Neurology ; Neurosciences ; Nutrient deficiency ; Nutrients ; Organs ; Proteomics ; Synaptogenesis</subject><ispartof>Journal of molecular neuroscience, 2019-05, Vol.68 (1), p.1-10</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Journal of Molecular Neuroscience is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-1a7ebc8e501dc30b818e13813861b41da5aafa697e9c15e07071d2786cb508ef3</citedby><cites>FETCH-LOGICAL-c441t-1a7ebc8e501dc30b818e13813861b41da5aafa697e9c15e07071d2786cb508ef3</cites><orcidid>0000-0003-2632-3935</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-019-01276-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-019-01276-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30778834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pivina, Lyudmila</creatorcontrib><creatorcontrib>Semenova, Yuliya</creatorcontrib><creatorcontrib>Doşa, Monica Daniela</creatorcontrib><creatorcontrib>Dauletyarova, Marzhan</creatorcontrib><creatorcontrib>Bjørklund, Geir</creatorcontrib><title>Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>More than 25% of the world’s population is affected by anemia, of which more than 50% suffers from iron deficiency anemia (IDA). Children below 7 years of age are the population group that is most vulnerable to iron deficiency. Iron is an essential element in brain metabolism. Iron deficiency can cause changes in neurotransmitter homeostasis, decrease myelin production, impair synaptogenesis, and decline the function of the basal ganglia. Therefore, IDA adversely affects cognitive functions and psychomotor development. Research has shown that iron deficiency is a frequent comorbidity in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder. Iron deficiency may also induce or exacerbate deficiency of other essential nutrients, which may have a negative impact on the developing brain and other organs in infants. Many nations of the world have programs to control IDA based on the use of iron supplementation, intake of fortified food and drinks, improved food safety, and monitoring of dietary diversity. Based on the current recommendations of the World Health Organization on cost-effectiveness (WHO-CHOICE), iron fortification and iron supplementation programs can be considered cost-effective or even highly cost-effective in most countries of the world to averting cognitive impairment.</description><subject>Anemia</subject><subject>Anemia, Iron-Deficiency - complications</subject><subject>Anemia, Iron-Deficiency - epidemiology</subject><subject>Anemia, Iron-Deficiency - physiopathology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Basal ganglia</subject><subject>Beverages</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Child Behavior</subject><subject>Children</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cost of Illness</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Developmental Disabilities - etiology</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Essential nutrients</subject><subject>Food</subject><subject>Food intake</subject><subject>Food safety</subject><subject>Ganglia</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Infants</subject><subject>Iron</subject><subject>Iron deficiency</subject><subject>Metabolism</subject><subject>Myelin</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nutrient deficiency</subject><subject>Nutrients</subject><subject>Organs</subject><subject>Proteomics</subject><subject>Synaptogenesis</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQJNYGfPmyM6KUQqWKLjBbjnNpXbV2sZNK_fekpMCGdKcb7v2QHkJugT4ApezRQ0RjCCnk3UYsC-GMDCFN8xAgy87JkPI8DXmWZwNy5f2a0ggS4JdkEFPGOI-TIVnMnDXBBGutNBp1GAeFXRrd6D0G09aoRlvjx4E0VfCGrbMlruReWyc3wUR76yp0PtAmKFZ6Uzk01-SilhuPN6c7Ih_T5_fiNZwvXmbF0zxUSQJNCJJhqTimFCoV05IDR4h5NxmUCVQylbKWWc4wV5AiZZRBFTGeqTKlHOt4RO773J2zny36Rqxt60xXKSLgUZ4mDKBTRb1KOeu9w1rsnN5KdxBAxZGh6BmKjqH4ZiiOprtTdFtusfq1_EDrBHEv8N3LLNH9df8T-wU8Ynus</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Pivina, Lyudmila</creator><creator>Semenova, Yuliya</creator><creator>Doşa, Monica Daniela</creator><creator>Dauletyarova, Marzhan</creator><creator>Bjørklund, Geir</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0003-2632-3935</orcidid></search><sort><creationdate>20190501</creationdate><title>Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children</title><author>Pivina, Lyudmila ; Semenova, Yuliya ; Doşa, Monica Daniela ; Dauletyarova, Marzhan ; Bjørklund, Geir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-1a7ebc8e501dc30b818e13813861b41da5aafa697e9c15e07071d2786cb508ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anemia</topic><topic>Anemia, Iron-Deficiency - complications</topic><topic>Anemia, Iron-Deficiency - epidemiology</topic><topic>Anemia, Iron-Deficiency - physiopathology</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Autism</topic><topic>Basal ganglia</topic><topic>Beverages</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Child</topic><topic>Child Behavior</topic><topic>Children</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cost of Illness</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Developmental Disabilities - etiology</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Essential nutrients</topic><topic>Food</topic><topic>Food intake</topic><topic>Food safety</topic><topic>Ganglia</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Infants</topic><topic>Iron</topic><topic>Iron deficiency</topic><topic>Metabolism</topic><topic>Myelin</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nutrient deficiency</topic><topic>Nutrients</topic><topic>Organs</topic><topic>Proteomics</topic><topic>Synaptogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pivina, Lyudmila</creatorcontrib><creatorcontrib>Semenova, Yuliya</creatorcontrib><creatorcontrib>Doşa, Monica Daniela</creatorcontrib><creatorcontrib>Dauletyarova, Marzhan</creatorcontrib><creatorcontrib>Bjørklund, Geir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pivina, Lyudmila</au><au>Semenova, Yuliya</au><au>Doşa, Monica Daniela</au><au>Dauletyarova, Marzhan</au><au>Bjørklund, Geir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><addtitle>J Mol Neurosci</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>68</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>More than 25% of the world’s population is affected by anemia, of which more than 50% suffers from iron deficiency anemia (IDA). Children below 7 years of age are the population group that is most vulnerable to iron deficiency. Iron is an essential element in brain metabolism. Iron deficiency can cause changes in neurotransmitter homeostasis, decrease myelin production, impair synaptogenesis, and decline the function of the basal ganglia. Therefore, IDA adversely affects cognitive functions and psychomotor development. Research has shown that iron deficiency is a frequent comorbidity in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder. Iron deficiency may also induce or exacerbate deficiency of other essential nutrients, which may have a negative impact on the developing brain and other organs in infants. Many nations of the world have programs to control IDA based on the use of iron supplementation, intake of fortified food and drinks, improved food safety, and monitoring of dietary diversity. Based on the current recommendations of the World Health Organization on cost-effectiveness (WHO-CHOICE), iron fortification and iron supplementation programs can be considered cost-effective or even highly cost-effective in most countries of the world to averting cognitive impairment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30778834</pmid><doi>10.1007/s12031-019-01276-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2632-3935</orcidid></addata></record> |
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| subjects | Anemia Anemia, Iron-Deficiency - complications Anemia, Iron-Deficiency - epidemiology Anemia, Iron-Deficiency - physiopathology Attention deficit hyperactivity disorder Autism Basal ganglia Beverages Biomedical and Life Sciences Biomedicine Brain Cell Biology Child Child Behavior Children Cognition Cognitive ability Cost of Illness Developmental Disabilities - epidemiology Developmental Disabilities - etiology Diet Dietary supplements Essential nutrients Food Food intake Food safety Ganglia Homeostasis Humans Hyperactivity Infants Iron Iron deficiency Metabolism Myelin Neurochemistry Neurology Neurosciences Nutrient deficiency Nutrients Organs Proteomics Synaptogenesis |
| title | Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children |
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