An Unexpected Role of Hyaluronic Acid in Trafficking siRNA Across the Cellular Barrier: The First Biomimetic, Anionic, Non‐Viral Transfection Method

Circulating nucleic acids, such as short interfering RNA (siRNA), regulate many biological processes; however, the mechanism by which these molecules enter the cell is poorly understood. The role of extracellular‐matrix‐derived polymers in binding siRNAs and trafficking them across the plasma membra...

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Veröffentlicht in:Angewandte Chemie 2019-02, Vol.131 (9), p.2841-2845
Hauptverfasser: Paidikondala, Maruthibabu, Rangasami, Vignesh Kumar, Nawale, Ganesh N., Casalini, Tommaso, Perale, Giuseppe, Kadekar, Sandeep, Mohanty, Gaurav, Salminen, Turkka, Oommen, Oommen P., Varghese, Oommen P.
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Sprache:eng
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