Synergistic roles of acyl‐CoA binding protein (ACBP1) and sterol carrier protein 2 (SCP2) in Toxoplasma lipid metabolism

Toxoplasma gondii relies on apicoplast‐localised FASII pathway and endoplasmic reticulum‐associated fatty acid elongation pathway for the synthesis of fatty acids, which flow through lipid metabolism mainly in the form of long‐chain acyl‐CoA (LCACoAs) esters. Functions of Toxoplasma acyl‐CoA transpo...

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Veröffentlicht in:	Cellular microbiology 2019-03, Vol.21 (3), p.e12970-n/a
Hauptverfasser:	Fu, Yong, Cui, Xia, Liu, Jing, Zhang, Xiao, Zhang, Heng, Yang, Congshan, Liu, Qun
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl‐CoA transporter Animals Carrier Proteins - genetics Carrier Proteins - metabolism Chromatography Defects Diazepam Binding Inhibitor - genetics Diazepam Binding Inhibitor - metabolism Disease Models, Animal Elongation Endoplasmic reticulum Esters Fatty acids Gas chromatography gene disruption Gene Knockout Techniques Glycerides High performance liquid chromatography Labeling Lipid Metabolism Lipids Liquid chromatography Mass spectrometry Mass spectroscopy Metabolism Mice Parasites Phospholipids Protein Binding Protein turnover Proteins Protozoan Proteins - genetics Protozoan Proteins - metabolism Scientific imaging Spectroscopy Sterols Synthesis Toxoplasma Toxoplasma - enzymology Toxoplasma - growth & development Toxoplasma - metabolism Toxoplasma - pathogenicity Toxoplasmosis - parasitology Toxoplasmosis - pathology Virulence Virulence Factors - genetics Virulence Factors - metabolism Yeast
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