Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy

Background. Interstitial inflammation is a prominent feature associated with the severity of renal injury and progressive kidney failure. We utilized an animal model of aristolochic acid (AA)-induced nephropathy (AAN) to assess patterns of infiltration and inflammation during the evolution of tubulo...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2008-08, Vol.23 (8), p.2480-2491
Hauptverfasser:	Pozdzik, Agnieszka A., Salmon, Isabelle J., Husson, Cécile P., Decaestecker, Christine, Rogier, Edith, Bourgeade, Marie-Françoise, Deschodt-Lanckman, Monique M., Vanherweghem, Jean-Louis, Nortier, Joëlle L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals aristolochic acid Aristolochic Acids - toxicity Biological and medical sciences Disease Models, Animal Emergency and intensive care: renal failure. Dialysis management Fibrosis Intensive care medicine Kidney - drug effects Kidney - pathology Kidney - physiopathology Kidney Failure, Chronic - chemically induced Kidney Failure, Chronic - pathology Kidney Failure, Chronic - physiopathology macrophages Macrophages - immunology Macrophages - pathology Male Medical sciences Monocytes - immunology Monocytes - pathology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Rats Rats, Wistar Renal failure renal fibrosis Signal Transduction Smad2 Protein - metabolism Smad3 Protein - metabolism T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - pathology Transforming Growth Factor beta - metabolism transforming growth factor-β
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