High molecular weight plasma proteins induce apoptosis and Fas/FasL expression in human proximal tubular cells

Background. In proteinuria, proximal tubular epithelial cells (PTECs) are exposed to abnormally high protein concentrations, eventually leading to tubular atrophy and end-stage renal disease. The mode of cell death leading to tubular atrophy in proteinuria has not been fully established. This study...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2005-01, Vol.20 (1), p.50-58
Hauptverfasser:	Morais, Christudas, Westhuyzen, Justin, Metharom, Pat, Healy, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy apoptosis Apoptosis - physiology Biological and medical sciences Blood Proteins - pharmacology Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Blotting, Western Cell Proliferation Cell Survival Cells, Cultured Emergency and intensive care: renal failure. Dialysis management Epithelial Cells - physiology Fas Fas Ligand Protein Female Flow Cytometry Fundamental and applied biological sciences. Psychology Humans In Situ Nick-End Labeling Intensive care medicine Kidney Tubules - cytology Male Medical sciences Membrane Glycoproteins - analysis Membrane Glycoproteins - metabolism Molecular Weight Necrosis protein overload proximal tubular epithelial cells Reference Values Sensitivity and Specificity Serum Albumin Serum Albumin, Human Serum Globulins Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vertebrates: urinary system
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