Temperature-dependent responses of rats to ergovaline derived from endophyte-infected tall fescue
Ergovaline, found in Acremonium coenophialum-infected tall fescue, is considered to be responsible for many symptoms associated with fescue toxicosis. Rats were tested to determine time-related thermoregulatory responses to acute treatment with ergovaline during specific thermal challenges. Isolated...
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| Veröffentlicht in: | Journal of animal science 1995-07, Vol.73 (7), p.1954-1961 |
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| container_end_page | 1961 |
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| container_issue | 7 |
| container_start_page | 1954 |
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| creator | Spiers, D. E Zhang, Q Eichen, P. A Rottinghaus, G. E Garner, G. B Ellersieck, M. R |
| description | Ergovaline, found in Acremonium coenophialum-infected tall fescue, is considered to be responsible for many symptoms associated with fescue toxicosis. Rats were tested to determine time-related thermoregulatory responses to acute treatment with ergovaline during specific thermal challenges. Isolated ergovaline was administered to rats (15 micrograms/kg body mass, i.p.) at controlled ambient temperatures (Ta) of 7 to 9 degrees C (cold) and 31 to 33 degrees C (hot). Treatment at cold Ta resulted in a decrease in rectal temperature (Tre) from 38.0 to 37.0 degrees C at 50 min after injection (P < 0.05) without complete return to preinjection value at 100 min. Tail temperature (Ttail) exhibited a concomitant 1 degree C decrease (P < 0.05) after ergovaline injection at cold Ta. Also, metabolic heat production decreased from 15.7 to 11.7 W/kg at 20 min after injection of ergovaline (P < 0.05), with return to normal value al 40 min after injection. Injection of ergovaline at hot Ta increased Tre from 39.0 to 40.6 degrees C at 80 min after injection (P < 0.05), with no return to preinjection value at 100 min. This was attributed to a reduction in heat transfer across the tail as indicated by the decrease in Ttail from 37.1 to 36.4 degrees C at 40 min after injection (P < 0.05) and an initial increase in metabolic heat production from 8.4 to 9.4 W/kg at 3 min after injection (P < 0.05). Ambient temperature was found to be a major determinant of ergovaline response, which included alterations in both thermogenic and thermolytic mechanisms that control thermal balance. |
| doi_str_mv | 10.2527/1995.7371954x |
| format | Article |
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E ; Zhang, Q ; Eichen, P. A ; Rottinghaus, G. E ; Garner, G. B ; Ellersieck, M. R</creator><creatorcontrib>Spiers, D. E ; Zhang, Q ; Eichen, P. A ; Rottinghaus, G. E ; Garner, G. B ; Ellersieck, M. R ; University of Missouri-Columbia, Columbia ; Universidad Catolica de Chile, Santiago (Chile). Fac. de Agronomia</creatorcontrib><description><![CDATA[Ergovaline, found in Acremonium coenophialum-infected tall fescue, is considered to be responsible for many symptoms associated with fescue toxicosis. Rats were tested to determine time-related thermoregulatory responses to acute treatment with ergovaline during specific thermal challenges. Isolated ergovaline was administered to rats (15 micrograms/kg body mass, i.p.) at controlled ambient temperatures (Ta) of 7 to 9 degrees C (cold) and 31 to 33 degrees C (hot). Treatment at cold Ta resulted in a decrease in rectal temperature (Tre) from 38.0 to 37.0 degrees C at 50 min after injection (P < 0.05) without complete return to preinjection value at 100 min. Tail temperature (Ttail) exhibited a concomitant 1 degree C decrease (P < 0.05) after ergovaline injection at cold Ta. Also, metabolic heat production decreased from 15.7 to 11.7 W/kg at 20 min after injection of ergovaline (P < 0.05), with return to normal value al 40 min after injection. Injection of ergovaline at hot Ta increased Tre from 39.0 to 40.6 degrees C at 80 min after injection (P < 0.05), with no return to preinjection value at 100 min. This was attributed to a reduction in heat transfer across the tail as indicated by the decrease in Ttail from 37.1 to 36.4 degrees C at 40 min after injection (P < 0.05) and an initial increase in metabolic heat production from 8.4 to 9.4 W/kg at 3 min after injection (P < 0.05). Ambient temperature was found to be a major determinant of ergovaline response, which included alterations in both thermogenic and thermolytic mechanisms that control thermal balance.]]></description><identifier>ISSN: 0021-8812</identifier><identifier>EISSN: 1525-3163</identifier><identifier>DOI: 10.2527/1995.7371954x</identifier><identifier>PMID: 7592079</identifier><language>eng</language><publisher>Savoy, IL: Am Soc Animal Sci</publisher><subject>acremonium ; Acremonium - growth & development ; Acremonium - metabolism ; alcaloide de l' ergot de seigle ; Animals ; Biological and medical sciences ; body temperature ; Body Temperature Regulation - physiology ; cola anatomia animal ; cold ; Disease ; environmental temperature ; ergot alkaloids ; Ergotamines - toxicity ; ergotinas ; estres ; estres termico ; festuca arundinacea ; frio ; froid ; Fundamental and applied biological sciences. Psychology ; heat stress ; Male ; Poaceae - microbiology ; queue ; Random Allocation ; rat ; rata ; Rats ; Rats, Sprague-Dawley ; Regression Analysis ; Rodents ; stress ; stress thermique ; tail ; temperatura ambiental ; temperatura del cuerpo ; Temperature ; temperature ambiante ; temperature corporelle ; termorregulacion ; thermoregulation ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Time Factors ; Vasoconstrictor Agents - toxicity ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of animal science, 1995-07, Vol.73 (7), p.1954-1961</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright American Society of Animal Science Jul 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-fdc27a42948296d5f924ef50d4f84e354106d87e90cdfb99bac39f98a13e95c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3578918$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7592079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spiers, D. E</creatorcontrib><creatorcontrib>Zhang, Q</creatorcontrib><creatorcontrib>Eichen, P. A</creatorcontrib><creatorcontrib>Rottinghaus, G. E</creatorcontrib><creatorcontrib>Garner, G. B</creatorcontrib><creatorcontrib>Ellersieck, M. R</creatorcontrib><creatorcontrib>University of Missouri-Columbia, Columbia</creatorcontrib><creatorcontrib>Universidad Catolica de Chile, Santiago (Chile). Fac. de Agronomia</creatorcontrib><title>Temperature-dependent responses of rats to ergovaline derived from endophyte-infected tall fescue</title><title>Journal of animal science</title><addtitle>J Anim Sci</addtitle><description><![CDATA[Ergovaline, found in Acremonium coenophialum-infected tall fescue, is considered to be responsible for many symptoms associated with fescue toxicosis. Rats were tested to determine time-related thermoregulatory responses to acute treatment with ergovaline during specific thermal challenges. Isolated ergovaline was administered to rats (15 micrograms/kg body mass, i.p.) at controlled ambient temperatures (Ta) of 7 to 9 degrees C (cold) and 31 to 33 degrees C (hot). Treatment at cold Ta resulted in a decrease in rectal temperature (Tre) from 38.0 to 37.0 degrees C at 50 min after injection (P < 0.05) without complete return to preinjection value at 100 min. Tail temperature (Ttail) exhibited a concomitant 1 degree C decrease (P < 0.05) after ergovaline injection at cold Ta. Also, metabolic heat production decreased from 15.7 to 11.7 W/kg at 20 min after injection of ergovaline (P < 0.05), with return to normal value al 40 min after injection. Injection of ergovaline at hot Ta increased Tre from 39.0 to 40.6 degrees C at 80 min after injection (P < 0.05), with no return to preinjection value at 100 min. This was attributed to a reduction in heat transfer across the tail as indicated by the decrease in Ttail from 37.1 to 36.4 degrees C at 40 min after injection (P < 0.05) and an initial increase in metabolic heat production from 8.4 to 9.4 W/kg at 3 min after injection (P < 0.05). Ambient temperature was found to be a major determinant of ergovaline response, which included alterations in both thermogenic and thermolytic mechanisms that control thermal balance.]]></description><subject>acremonium</subject><subject>Acremonium - growth & development</subject><subject>Acremonium - metabolism</subject><subject>alcaloide de l' ergot de seigle</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>body temperature</subject><subject>Body Temperature Regulation - physiology</subject><subject>cola anatomia animal</subject><subject>cold</subject><subject>Disease</subject><subject>environmental temperature</subject><subject>ergot alkaloids</subject><subject>Ergotamines - toxicity</subject><subject>ergotinas</subject><subject>estres</subject><subject>estres termico</subject><subject>festuca arundinacea</subject><subject>frio</subject><subject>froid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>heat stress</subject><subject>Male</subject><subject>Poaceae - microbiology</subject><subject>queue</subject><subject>Random Allocation</subject><subject>rat</subject><subject>rata</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regression Analysis</subject><subject>Rodents</subject><subject>stress</subject><subject>stress thermique</subject><subject>tail</subject><subject>temperatura ambiental</subject><subject>temperatura del cuerpo</subject><subject>Temperature</subject><subject>temperature ambiante</subject><subject>temperature corporelle</subject><subject>termorregulacion</subject><subject>thermoregulation</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>Time Factors</subject><subject>Vasoconstrictor Agents - toxicity</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0021-8812</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1r3DAQhkVpSbdpjz22iFJ6c6IPa6U5htAvCOSQ5Cy00mjXi225kp02_z5adpuTQO8z7wwPIR85uxBK6EsOoC601BxU--8VWXElVCP5Wr4mK8YEb4zh4i15V8qeMS4UqDNyphUIpmFF3D0OE2Y3LxmbgBOOAceZZixTGgsWmiKtaaFzopi36dH13Yg0YO4eMdCY00DrTJp2TzM23RjRz_V_dn1PIxa_4HvyJrq-4IfTe04efny_v_7V3Nz-_H19ddN4CWZuYvBCu1ZAawSsg4ogWoyKhTaaFqVqOVsHoxGYD3EDsHF1LoJxXCIoD_KcfDn2Tjn9WbDMdp-WPNaVVnDDpTFaVKg5Qj6nUjJGO-VucPnJcmYPOu1Bp_2vs_KfTqXLZsDwQp_81fzrKXfFuz5mN_quvGBSaQPcVOzbEdt1293fLqMtQzVUS7ndu6KlPSxWbQU_H8HoknXbXLse7upJa8aUlkbKZ8dAk-4</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Spiers, D. E</creator><creator>Zhang, Q</creator><creator>Eichen, P. A</creator><creator>Rottinghaus, G. E</creator><creator>Garner, G. B</creator><creator>Ellersieck, M. R</creator><general>Am Soc Animal Sci</general><general>American Society of Animal Science</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>U9A</scope></search><sort><creationdate>19950701</creationdate><title>Temperature-dependent responses of rats to ergovaline derived from endophyte-infected tall fescue</title><author>Spiers, D. E ; Zhang, Q ; Eichen, P. A ; Rottinghaus, G. E ; Garner, G. B ; Ellersieck, M. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-fdc27a42948296d5f924ef50d4f84e354106d87e90cdfb99bac39f98a13e95c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>acremonium</topic><topic>Acremonium - growth & development</topic><topic>Acremonium - metabolism</topic><topic>alcaloide de l' ergot de seigle</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>body temperature</topic><topic>Body Temperature Regulation - physiology</topic><topic>cola anatomia animal</topic><topic>cold</topic><topic>Disease</topic><topic>environmental temperature</topic><topic>ergot alkaloids</topic><topic>Ergotamines - toxicity</topic><topic>ergotinas</topic><topic>estres</topic><topic>estres termico</topic><topic>festuca arundinacea</topic><topic>frio</topic><topic>froid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>heat stress</topic><topic>Male</topic><topic>Poaceae - microbiology</topic><topic>queue</topic><topic>Random Allocation</topic><topic>rat</topic><topic>rata</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regression Analysis</topic><topic>Rodents</topic><topic>stress</topic><topic>stress thermique</topic><topic>tail</topic><topic>temperatura ambiental</topic><topic>temperatura del cuerpo</topic><topic>Temperature</topic><topic>temperature ambiante</topic><topic>temperature corporelle</topic><topic>termorregulacion</topic><topic>thermoregulation</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Time Factors</topic><topic>Vasoconstrictor Agents - toxicity</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spiers, D. E</creatorcontrib><creatorcontrib>Zhang, Q</creatorcontrib><creatorcontrib>Eichen, P. A</creatorcontrib><creatorcontrib>Rottinghaus, G. E</creatorcontrib><creatorcontrib>Garner, G. B</creatorcontrib><creatorcontrib>Ellersieck, M. R</creatorcontrib><creatorcontrib>University of Missouri-Columbia, Columbia</creatorcontrib><creatorcontrib>Universidad Catolica de Chile, Santiago (Chile). Fac. de Agronomia</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spiers, D. E</au><au>Zhang, Q</au><au>Eichen, P. A</au><au>Rottinghaus, G. E</au><au>Garner, G. B</au><au>Ellersieck, M. R</au><aucorp>University of Missouri-Columbia, Columbia</aucorp><aucorp>Universidad Catolica de Chile, Santiago (Chile). Fac. de Agronomia</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature-dependent responses of rats to ergovaline derived from endophyte-infected tall fescue</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>73</volume><issue>7</issue><spage>1954</spage><epage>1961</epage><pages>1954-1961</pages><issn>0021-8812</issn><eissn>1525-3163</eissn><abstract><![CDATA[Ergovaline, found in Acremonium coenophialum-infected tall fescue, is considered to be responsible for many symptoms associated with fescue toxicosis. Rats were tested to determine time-related thermoregulatory responses to acute treatment with ergovaline during specific thermal challenges. Isolated ergovaline was administered to rats (15 micrograms/kg body mass, i.p.) at controlled ambient temperatures (Ta) of 7 to 9 degrees C (cold) and 31 to 33 degrees C (hot). Treatment at cold Ta resulted in a decrease in rectal temperature (Tre) from 38.0 to 37.0 degrees C at 50 min after injection (P < 0.05) without complete return to preinjection value at 100 min. Tail temperature (Ttail) exhibited a concomitant 1 degree C decrease (P < 0.05) after ergovaline injection at cold Ta. Also, metabolic heat production decreased from 15.7 to 11.7 W/kg at 20 min after injection of ergovaline (P < 0.05), with return to normal value al 40 min after injection. Injection of ergovaline at hot Ta increased Tre from 39.0 to 40.6 degrees C at 80 min after injection (P < 0.05), with no return to preinjection value at 100 min. This was attributed to a reduction in heat transfer across the tail as indicated by the decrease in Ttail from 37.1 to 36.4 degrees C at 40 min after injection (P < 0.05) and an initial increase in metabolic heat production from 8.4 to 9.4 W/kg at 3 min after injection (P < 0.05). Ambient temperature was found to be a major determinant of ergovaline response, which included alterations in both thermogenic and thermolytic mechanisms that control thermal balance.]]></abstract><cop>Savoy, IL</cop><pub>Am Soc Animal Sci</pub><pmid>7592079</pmid><doi>10.2527/1995.7371954x</doi><tpages>8</tpages></addata></record> |
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| subjects | acremonium Acremonium - growth & development Acremonium - metabolism alcaloide de l' ergot de seigle Animals Biological and medical sciences body temperature Body Temperature Regulation - physiology cola anatomia animal cold Disease environmental temperature ergot alkaloids Ergotamines - toxicity ergotinas estres estres termico festuca arundinacea frio froid Fundamental and applied biological sciences. Psychology heat stress Male Poaceae - microbiology queue Random Allocation rat rata Rats Rats, Sprague-Dawley Regression Analysis Rodents stress stress thermique tail temperatura ambiental temperatura del cuerpo Temperature temperature ambiante temperature corporelle termorregulacion thermoregulation Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Time Factors Vasoconstrictor Agents - toxicity Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Temperature-dependent responses of rats to ergovaline derived from endophyte-infected tall fescue |
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