Changes of percentages in immune cells phenotypes and cytokines production during two-year IFN-?-1a treatment in multiple sclerosis patients

Changes of percentages in immune cells phenotypes and cytokines production during two-year IFN-?-1a treatment in multiple sclerosis patients

The aim of the study was to find out whether INF-beta-1a influences the immune profile of peripheral blood (PB) leukocytes in MS patients. We have studied 20 patients with relapsing-remitting form of MS treated with INF-beta-1a using twocolor cytometry. We determined immune cells phenotypes and prod...

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Veröffentlicht in:Journal of neurology 2003-10, Vol.250 (10), p.1229-1236
Hauptverfasser: Mirowska, Dagmara, Skierski, Janusz, Paz, Aleksandra, Koronkiewicz, Miroslawa, Zaborski, Jacek, Kruszewska, Jadwiga, Czlonkowski, Andrzej, Czlonkowska, Anna
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container_end_page 1236
container_issue 10
container_start_page 1229
container_title Journal of neurology
container_volume 250
creator Mirowska, Dagmara
Skierski, Janusz
Paz, Aleksandra
Koronkiewicz, Miroslawa
Zaborski, Jacek
Kruszewska, Jadwiga
Czlonkowski, Andrzej
Czlonkowska, Anna
description The aim of the study was to find out whether INF-beta-1a influences the immune profile of peripheral blood (PB) leukocytes in MS patients. We have studied 20 patients with relapsing-remitting form of MS treated with INF-beta-1a using twocolor cytometry. We determined immune cells phenotypes and production of some cytokines: IL-4, IL-10, IL-12, IFN-gamma, before drug administration and after starting the treatment. In MS patients an increased percentage of CD14(+)CD86(+) cells and CD3(+)CD25(+) cells was noticed after 6, 9 and 12 months of INF-beta-1a therapy. Among cytokine-producing cells we noted an increased fraction of CD3(+)IL-4, CD14(+)IL-10 and CD14(+)IL-12 cells after 12 months, which decreased to the level observed before treatment after 24-month therapy. IFN-beta-1a treatment was associated with significant changes in immune response. This effect was mostly evident within the first year of treatment.
doi_str_mv 10.1007/s00415-003-0170-9
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title Changes of percentages in immune cells phenotypes and cytokines production during two-year IFN-?-1a treatment in multiple sclerosis patients
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