INTRACELLULAR SIGNALING FROM THE ENDOPLASMIC RETICULUM TO THE NUCLEUS

Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway called the unfolded protein response (UPR)...

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Veröffentlicht in:	Annual review of cell and developmental biology 1998-01, Vol.14 (1), p.459-485
Hauptverfasser:	Chapman, Rowan, Sidrauski, Carmela, Walter, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - physiology Endoplasmic Reticulum - physiology Gene Expression Regulation Humans mRNA splicing Protein Folding RNA Splicing RNA, Messenger - genetics Saccharomyces cerevisiae - physiology Signal Transduction - physiology Transcription, Genetic transcriptional regulation translation regulation transmembrane kinase tRNA ligase
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