Reaction‐Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable‐Temperature Kinetic Studies
A water‐soluble europium(III)‐based probe, EuL, has been designed and synthesized for selective recognition of cysteine (Cys) over other structurally similar thiols and amino derivatives due to formation of a more stable and preferable seven‐membered ring. Addition of Cys shows a significant respons...
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| Veröffentlicht in: | European journal of inorganic chemistry 2019-02, Vol.2019 (6), p.813-820 |
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| container_title | European journal of inorganic chemistry |
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| creator | Yip, Yuk‐Wang Yan, Zhiyuan Law, Ga‐Lai Wong, Wing‐Tak |
| description | A water‐soluble europium(III)‐based probe, EuL, has been designed and synthesized for selective recognition of cysteine (Cys) over other structurally similar thiols and amino derivatives due to formation of a more stable and preferable seven‐membered ring. Addition of Cys shows a significant response with quenching of over 90 % of the initial signal (Hcys: 10.5 %, GSH: 3.6 % respectively). A good linear correlation between the emission intensities and concentrations of Cys has been established.
Water‐soluble EuL is highly selective for detection of cysteine (Cys) over other thiol and amino derivatives with a linear relationship correlating the luminescence intensity and the concentration of Cys (5 µm to 80 µm). EuL is stable from pH 4 to 8. Kinetic studies showed that EuL has a higher quenching rate with Cys than both Hcys and GSH. |
| doi_str_mv | 10.1002/ejic.201801315 |
| format | Article |
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Water‐soluble EuL is highly selective for detection of cysteine (Cys) over other thiol and amino derivatives with a linear relationship correlating the luminescence intensity and the concentration of Cys (5 µm to 80 µm). EuL is stable from pH 4 to 8. Kinetic studies showed that EuL has a higher quenching rate with Cys than both Hcys and GSH.</description><identifier>ISSN: 1434-1948</identifier><identifier>EISSN: 1099-0682</identifier><identifier>DOI: 10.1002/ejic.201801315</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Cysteine ; Europium ; Glutathione ; Inorganic chemistry ; Macrocycles ; Reaction mechanisms ; Sensors ; Thiols</subject><ispartof>European journal of inorganic chemistry, 2019-02, Vol.2019 (6), p.813-820</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3575-dd2f0fc2514218c14ca68f622c45bf15d02a0ccad8cddd23c006ab0cae34511a3</citedby><cites>FETCH-LOGICAL-c3575-dd2f0fc2514218c14ca68f622c45bf15d02a0ccad8cddd23c006ab0cae34511a3</cites><orcidid>0000-0002-3453-1825 ; 0000-0002-2192-6887</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejic.201801315$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejic.201801315$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids></links><search><creatorcontrib>Yip, Yuk‐Wang</creatorcontrib><creatorcontrib>Yan, Zhiyuan</creatorcontrib><creatorcontrib>Law, Ga‐Lai</creatorcontrib><creatorcontrib>Wong, Wing‐Tak</creatorcontrib><title>Reaction‐Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable‐Temperature Kinetic Studies</title><title>European journal of inorganic chemistry</title><description>A water‐soluble europium(III)‐based probe, EuL, has been designed and synthesized for selective recognition of cysteine (Cys) over other structurally similar thiols and amino derivatives due to formation of a more stable and preferable seven‐membered ring. Addition of Cys shows a significant response with quenching of over 90 % of the initial signal (Hcys: 10.5 %, GSH: 3.6 % respectively). A good linear correlation between the emission intensities and concentrations of Cys has been established.
Water‐soluble EuL is highly selective for detection of cysteine (Cys) over other thiol and amino derivatives with a linear relationship correlating the luminescence intensity and the concentration of Cys (5 µm to 80 µm). EuL is stable from pH 4 to 8. Kinetic studies showed that EuL has a higher quenching rate with Cys than both Hcys and GSH.</description><subject>Cysteine</subject><subject>Europium</subject><subject>Glutathione</subject><subject>Inorganic chemistry</subject><subject>Macrocycles</subject><subject>Reaction mechanisms</subject><subject>Sensors</subject><subject>Thiols</subject><issn>1434-1948</issn><issn>1099-0682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRSMEEs8ta0usU8Z2kiZLCAUKSEgU2EauMxaukjrYDqU7PgHxiXwJhvJYsprR6Jw70o2ifQoDCsAOcablgAHNgXKarkVbFIoihixn62FPeBLTIsk3o23nZgDAgWdb0dsNCum1mb-_vB4LhzUZ9dZ0um9JadquwWeijCWTDqVWWpIT9PjFE6NIuXQe9RzJ9RNacm5aI38uYl6Ts6b3wj8EGMlC-wdyL6wW0wbDr1tsO7TC9xbJZRB8yJ74vtbodqMNJRqHe99zJ7o7Hd2W5_HV9dm4PLqKJU-HaVzXTIGSLKUJo7mkiRRZrjLGZJJOFU1rYAKkFHUu68ByCZCJKUiBPEkpFXwnOljldtY89uh8NTO9nYeXFaPDgg-LYpgFarCipDXOWVRVZ3Ur7LKiUH32Xn32Xv32HoRiJSx0g8t_6Gp0MS7_3A_oM4xS</recordid><startdate>20190214</startdate><enddate>20190214</enddate><creator>Yip, Yuk‐Wang</creator><creator>Yan, Zhiyuan</creator><creator>Law, Ga‐Lai</creator><creator>Wong, Wing‐Tak</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-3453-1825</orcidid><orcidid>https://orcid.org/0000-0002-2192-6887</orcidid></search><sort><creationdate>20190214</creationdate><title>Reaction‐Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable‐Temperature Kinetic Studies</title><author>Yip, Yuk‐Wang ; Yan, Zhiyuan ; Law, Ga‐Lai ; Wong, Wing‐Tak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3575-dd2f0fc2514218c14ca68f622c45bf15d02a0ccad8cddd23c006ab0cae34511a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cysteine</topic><topic>Europium</topic><topic>Glutathione</topic><topic>Inorganic chemistry</topic><topic>Macrocycles</topic><topic>Reaction mechanisms</topic><topic>Sensors</topic><topic>Thiols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yip, Yuk‐Wang</creatorcontrib><creatorcontrib>Yan, Zhiyuan</creatorcontrib><creatorcontrib>Law, Ga‐Lai</creatorcontrib><creatorcontrib>Wong, Wing‐Tak</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>European journal of inorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yip, Yuk‐Wang</au><au>Yan, Zhiyuan</au><au>Law, Ga‐Lai</au><au>Wong, Wing‐Tak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reaction‐Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable‐Temperature Kinetic Studies</atitle><jtitle>European journal of inorganic chemistry</jtitle><date>2019-02-14</date><risdate>2019</risdate><volume>2019</volume><issue>6</issue><spage>813</spage><epage>820</epage><pages>813-820</pages><issn>1434-1948</issn><eissn>1099-0682</eissn><abstract>A water‐soluble europium(III)‐based probe, EuL, has been designed and synthesized for selective recognition of cysteine (Cys) over other structurally similar thiols and amino derivatives due to formation of a more stable and preferable seven‐membered ring. Addition of Cys shows a significant response with quenching of over 90 % of the initial signal (Hcys: 10.5 %, GSH: 3.6 % respectively). A good linear correlation between the emission intensities and concentrations of Cys has been established.
Water‐soluble EuL is highly selective for detection of cysteine (Cys) over other thiol and amino derivatives with a linear relationship correlating the luminescence intensity and the concentration of Cys (5 µm to 80 µm). EuL is stable from pH 4 to 8. Kinetic studies showed that EuL has a higher quenching rate with Cys than both Hcys and GSH.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ejic.201801315</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3453-1825</orcidid><orcidid>https://orcid.org/0000-0002-2192-6887</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cysteine Europium Glutathione Inorganic chemistry Macrocycles Reaction mechanisms Sensors Thiols |
| title | Reaction‐Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable‐Temperature Kinetic Studies |
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