Hearing Loss as a Late Complication of Radiotherapy in Children with Brain Tumors
Late postirradiation hearing loss has been well described in the adult population. Few reports exist on the pediatric population. We conducted a retrospective review of 157 consecutive children with brain tumors treated exclusively with irradiation at St Jude Children's Research Hospital. Twent...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2005-04, Vol.114 (4), p.328-331 |
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| creator | Williams, Glenn B. Kun, Larry E. Gould, Herbert J. Thompson, Jerome W. Stocks, Rose Mary S. |
| description | Late postirradiation hearing loss has been well described in the adult population. Few reports exist on the pediatric population. We conducted a retrospective review of 157 consecutive children with brain tumors treated exclusively with irradiation at St Jude Children's Research Hospital. Twenty-six patients developed a hearing loss, 74 did not, and 57 were excluded because of incomplete records. We report a statistically significant 27.41% cumulative risk of a stringent 20-dB hearing loss in the voice frequency range by the fifth year after radiotherapy. The right side demonstrated a significant frequency effect, with a higher incidence of loss in the higher-frequency region. We found no difference in cumulative incidence of hearing shift between the low-, middle-, and high-frequency ranges for either ear. This risk should be anticipated and managed as part of the treatment plan for radiotherapy for the treatment of malignancies. Radiation-induced hearing loss is important to acknowledge so that techniques of hyperfractionation, total dose, ports, preservative infusion medical therapy, or prolonged medical intervention (such as anticoagulants) can be developed that might reduce this disabling problem of postirradiation sensorineural hearing loss in future patients. |
| doi_str_mv | 10.1177/000348940511400413 |
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Few reports exist on the pediatric population. We conducted a retrospective review of 157 consecutive children with brain tumors treated exclusively with irradiation at St Jude Children's Research Hospital. Twenty-six patients developed a hearing loss, 74 did not, and 57 were excluded because of incomplete records. We report a statistically significant 27.41% cumulative risk of a stringent 20-dB hearing loss in the voice frequency range by the fifth year after radiotherapy. The right side demonstrated a significant frequency effect, with a higher incidence of loss in the higher-frequency region. We found no difference in cumulative incidence of hearing shift between the low-, middle-, and high-frequency ranges for either ear. This risk should be anticipated and managed as part of the treatment plan for radiotherapy for the treatment of malignancies. Radiation-induced hearing loss is important to acknowledge so that techniques of hyperfractionation, total dose, ports, preservative infusion medical therapy, or prolonged medical intervention (such as anticoagulants) can be developed that might reduce this disabling problem of postirradiation sensorineural hearing loss in future patients.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940511400413</identifier><identifier>PMID: 15895790</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Audiometry, Pure-Tone ; Biological and medical sciences ; Brain Neoplasms - radiotherapy ; Child ; Child, Preschool ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Hearing Loss, Sensorineural - etiology ; Humans ; Medical sciences ; Non tumoral diseases ; Otorhinolaryngology. 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Few reports exist on the pediatric population. We conducted a retrospective review of 157 consecutive children with brain tumors treated exclusively with irradiation at St Jude Children's Research Hospital. Twenty-six patients developed a hearing loss, 74 did not, and 57 were excluded because of incomplete records. We report a statistically significant 27.41% cumulative risk of a stringent 20-dB hearing loss in the voice frequency range by the fifth year after radiotherapy. The right side demonstrated a significant frequency effect, with a higher incidence of loss in the higher-frequency region. We found no difference in cumulative incidence of hearing shift between the low-, middle-, and high-frequency ranges for either ear. This risk should be anticipated and managed as part of the treatment plan for radiotherapy for the treatment of malignancies. Radiation-induced hearing loss is important to acknowledge so that techniques of hyperfractionation, total dose, ports, preservative infusion medical therapy, or prolonged medical intervention (such as anticoagulants) can be developed that might reduce this disabling problem of postirradiation sensorineural hearing loss in future patients.</description><subject>Adolescent</subject><subject>Audiometry, Pure-Tone</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Hearing Loss, Sensorineural - etiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Radiation Injuries - complications</subject><subject>Retrospective Studies</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90E1LwzAYAOAgipvTP-BBguCxLmmapjlq8QsKouzgrbxN0y2jXyYtsn9vxgo7CEIgJDzvJ0LXlNxTKsSSEMKiREaEUxoRElF2guZURizgIvw6RfM9CPZihi6c2_pnxEl4jmaUJ5ILSebo41WDNe0aZ51zGPzBGQwap13T10bBYLoWdxX-hNJ0w0Zb6HfYtDjdmLq0usU_ZtjgRwv-bzU2nXWX6KyC2umr6V6g1fPTKn0NsveXt_QhCxSTyRAAMC5FrFSlohIIZzHnmouCJWUUlqBpVarCGwVCcVHFBYWKgFIlD5UsFFug20Pa3nbfo3ZDvu1G2_qKeUj9aFKGzKPwgJT141ld5b01DdhdTkm-32H-d4c-6GbKPBaNLo8h09I8uJsAOAV1ZaFVxh1dLCjz1LvlwTlY62N7_5T-BQ6ghoY</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Williams, Glenn B.</creator><creator>Kun, Larry E.</creator><creator>Gould, Herbert J.</creator><creator>Thompson, Jerome W.</creator><creator>Stocks, Rose Mary S.</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20050401</creationdate><title>Hearing Loss as a Late Complication of Radiotherapy in Children with Brain Tumors</title><author>Williams, Glenn B. ; Kun, Larry E. ; Gould, Herbert J. ; Thompson, Jerome W. ; Stocks, Rose Mary S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-aa35976ccfc4da053655e57b38d42dae1fdcba35ca7c57f6b1af0accd52c9bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Audiometry, Pure-Tone</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Hearing Loss, Sensorineural - etiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Radiation Injuries - complications</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Glenn B.</creatorcontrib><creatorcontrib>Kun, Larry E.</creatorcontrib><creatorcontrib>Gould, Herbert J.</creatorcontrib><creatorcontrib>Thompson, Jerome W.</creatorcontrib><creatorcontrib>Stocks, Rose Mary S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Glenn B.</au><au>Kun, Larry E.</au><au>Gould, Herbert J.</au><au>Thompson, Jerome W.</au><au>Stocks, Rose Mary S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hearing Loss as a Late Complication of Radiotherapy in Children with Brain Tumors</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>114</volume><issue>4</issue><spage>328</spage><epage>331</epage><pages>328-331</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Late postirradiation hearing loss has been well described in the adult population. Few reports exist on the pediatric population. We conducted a retrospective review of 157 consecutive children with brain tumors treated exclusively with irradiation at St Jude Children's Research Hospital. Twenty-six patients developed a hearing loss, 74 did not, and 57 were excluded because of incomplete records. We report a statistically significant 27.41% cumulative risk of a stringent 20-dB hearing loss in the voice frequency range by the fifth year after radiotherapy. The right side demonstrated a significant frequency effect, with a higher incidence of loss in the higher-frequency region. We found no difference in cumulative incidence of hearing shift between the low-, middle-, and high-frequency ranges for either ear. This risk should be anticipated and managed as part of the treatment plan for radiotherapy for the treatment of malignancies. Radiation-induced hearing loss is important to acknowledge so that techniques of hyperfractionation, total dose, ports, preservative infusion medical therapy, or prolonged medical intervention (such as anticoagulants) can be developed that might reduce this disabling problem of postirradiation sensorineural hearing loss in future patients.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>15895790</pmid><doi>10.1177/000348940511400413</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Audiometry, Pure-Tone Biological and medical sciences Brain Neoplasms - radiotherapy Child Child, Preschool Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Hearing Loss, Sensorineural - etiology Humans Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Radiation Injuries - complications Retrospective Studies |
| title | Hearing Loss as a Late Complication of Radiotherapy in Children with Brain Tumors |
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