Immunosuppressive Effect of Irradiation in the Murine Laryngeal Transplantation Model: A Controlled Trial
Since the first successful human laryngeal transplantation in 1998, research continues toward developing less-morbid immunosuppressive protocols. Although irradiation of donor organs is known to decrease acute rejection, the most advantageous method of radiation delivery is still unknown. Using a ra...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2003-08, Vol.112 (8), p.712-715 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Lorenz, Robert R. Dan, Olivia Nelson, Marc Fritz, Michael A. Strome, Marshall |
| description | Since the first successful human laryngeal transplantation in 1998, research continues toward developing less-morbid immunosuppressive protocols. Although irradiation of donor organs is known to decrease acute rejection, the most advantageous method of radiation delivery is still unknown. Using a rat laryngeal transplant model, we sought to determine the most beneficial timing and delivery method of irradiation. A prospective study was undertaken including 16 treatment arms of 10 to 30 animals each (189 transplantations). The animals received 800 cGy before transplantation to the donor larynx in vivo, the donor larynx in vitro, or the recipient animal's neck. The transplantation occurred at 24 hours, 5 days, or 10 days after irradiation. The transplanted larynges were harvested 15 days after transplantation and histologically scored for rejection. Irradiation of allogeneic transplantations demonstrated a strongly protective effect from rejection as compared to no irradiation (p < .001), regardless of the method of radiation delivery or the amount of time between irradiation and transplantation (p = .78). Irradiation of donor larynges between allogeneic rats has a protective effect, reducing the degree of acute rejection when irradiation is used as the single mode of immunosuppression, and is unrelated to either the timing or the mode of delivery of the irradiation. |
| doi_str_mv | 10.1177/000348940311200811 |
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Although irradiation of donor organs is known to decrease acute rejection, the most advantageous method of radiation delivery is still unknown. Using a rat laryngeal transplant model, we sought to determine the most beneficial timing and delivery method of irradiation. A prospective study was undertaken including 16 treatment arms of 10 to 30 animals each (189 transplantations). The animals received 800 cGy before transplantation to the donor larynx in vivo, the donor larynx in vitro, or the recipient animal's neck. The transplantation occurred at 24 hours, 5 days, or 10 days after irradiation. The transplanted larynges were harvested 15 days after transplantation and histologically scored for rejection. Irradiation of allogeneic transplantations demonstrated a strongly protective effect from rejection as compared to no irradiation (p < .001), regardless of the method of radiation delivery or the amount of time between irradiation and transplantation (p = .78). Irradiation of donor larynges between allogeneic rats has a protective effect, reducing the degree of acute rejection when irradiation is used as the single mode of immunosuppression, and is unrelated to either the timing or the mode of delivery of the irradiation.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940311200811</identifier><identifier>PMID: 12940670</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Graft Rejection - prevention & control ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Larynx - pathology ; Larynx - radiation effects ; Larynx - transplantation ; Medical sciences ; Models, Animal ; Prospective Studies ; Radiation Dosage ; Rats ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the upper aerodigestive tract ; Time Factors ; Transplantation Conditioning - methods ; Transplantation, Homologous</subject><ispartof>Annals of otology, rhinology & laryngology, 2003-08, Vol.112 (8), p.712-715</ispartof><rights>2003 SAGE Publications</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Annals Publishing Company Aug 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-d6d6e9f4a0aab3f97fec20517daa1f613f114fb0cd11357f5a4ba664a46b209e3</citedby><cites>FETCH-LOGICAL-c396t-d6d6e9f4a0aab3f97fec20517daa1f613f114fb0cd11357f5a4ba664a46b209e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000348940311200811$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000348940311200811$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15085676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12940670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorenz, Robert R.</creatorcontrib><creatorcontrib>Dan, Olivia</creatorcontrib><creatorcontrib>Nelson, Marc</creatorcontrib><creatorcontrib>Fritz, Michael A.</creatorcontrib><creatorcontrib>Strome, Marshall</creatorcontrib><title>Immunosuppressive Effect of Irradiation in the Murine Laryngeal Transplantation Model: A Controlled Trial</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>Since the first successful human laryngeal transplantation in 1998, research continues toward developing less-morbid immunosuppressive protocols. Although irradiation of donor organs is known to decrease acute rejection, the most advantageous method of radiation delivery is still unknown. Using a rat laryngeal transplant model, we sought to determine the most beneficial timing and delivery method of irradiation. A prospective study was undertaken including 16 treatment arms of 10 to 30 animals each (189 transplantations). The animals received 800 cGy before transplantation to the donor larynx in vivo, the donor larynx in vitro, or the recipient animal's neck. The transplantation occurred at 24 hours, 5 days, or 10 days after irradiation. The transplanted larynges were harvested 15 days after transplantation and histologically scored for rejection. Irradiation of allogeneic transplantations demonstrated a strongly protective effect from rejection as compared to no irradiation (p < .001), regardless of the method of radiation delivery or the amount of time between irradiation and transplantation (p = .78). Irradiation of donor larynges between allogeneic rats has a protective effect, reducing the degree of acute rejection when irradiation is used as the single mode of immunosuppression, and is unrelated to either the timing or the mode of delivery of the irradiation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Graft Rejection - prevention & control</subject><subject>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Larynx - pathology</subject><subject>Larynx - radiation effects</subject><subject>Larynx - transplantation</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Prospective Studies</subject><subject>Radiation Dosage</subject><subject>Rats</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the upper aerodigestive tract</subject><subject>Time Factors</subject><subject>Transplantation Conditioning - methods</subject><subject>Transplantation, Homologous</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90E1LwzAYB_Agis7pF_AgQfBYzdOmyeJNhi-DiRcFb-Vpm2ikS2rSCn57MzbYQfAUAr_n7U_IGbArACmvGWMFnynOCoCcsRnAHpmA4kVWyvxtn0zWIFuLI3Ic42f68pLlh-QI8lQlJJsQu1itRufj2PdBx2i_Nb0zRjcD9YYuQsDW4mC9o9bR4UPTpzFYp-kSw49719jRl4Au9h26YeOefKu7G3pL594NwXedbpOx2J2QA4Nd1Kfbd0pe7-9e5o_Z8vlhMb9dZk2hxJC1ohVaGY4MsS6MkmmZnJUgW0QwAgoDwE3NmhagKKUpkdcoBEcu6pwpXUzJxaZvH_zXqONQffoxuDSyykEqJkCphPINaoKPMWhT9cGu0lEVsGodbvU33FR0vu081ivd7kq2aSZwuQUYG-xMiqaxcedKNiuFFMldb1zEd71b75_Rv8IYj4M</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Lorenz, Robert R.</creator><creator>Dan, Olivia</creator><creator>Nelson, Marc</creator><creator>Fritz, Michael A.</creator><creator>Strome, Marshall</creator><general>SAGE Publications</general><general>Annals Publishing Compagny</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20030801</creationdate><title>Immunosuppressive Effect of Irradiation in the Murine Laryngeal Transplantation Model: A Controlled Trial</title><author>Lorenz, Robert R. ; Dan, Olivia ; Nelson, Marc ; Fritz, Michael A. ; Strome, Marshall</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-d6d6e9f4a0aab3f97fec20517daa1f613f114fb0cd11357f5a4ba664a46b209e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Graft Rejection - prevention & control</topic><topic>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Larynx - pathology</topic><topic>Larynx - radiation effects</topic><topic>Larynx - transplantation</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Prospective Studies</topic><topic>Radiation Dosage</topic><topic>Rats</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the upper aerodigestive tract</topic><topic>Time Factors</topic><topic>Transplantation Conditioning - methods</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorenz, Robert R.</creatorcontrib><creatorcontrib>Dan, Olivia</creatorcontrib><creatorcontrib>Nelson, Marc</creatorcontrib><creatorcontrib>Fritz, Michael A.</creatorcontrib><creatorcontrib>Strome, Marshall</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorenz, Robert R.</au><au>Dan, Olivia</au><au>Nelson, Marc</au><au>Fritz, Michael A.</au><au>Strome, Marshall</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppressive Effect of Irradiation in the Murine Laryngeal Transplantation Model: A Controlled Trial</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>112</volume><issue>8</issue><spage>712</spage><epage>715</epage><pages>712-715</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Since the first successful human laryngeal transplantation in 1998, research continues toward developing less-morbid immunosuppressive protocols. Although irradiation of donor organs is known to decrease acute rejection, the most advantageous method of radiation delivery is still unknown. Using a rat laryngeal transplant model, we sought to determine the most beneficial timing and delivery method of irradiation. A prospective study was undertaken including 16 treatment arms of 10 to 30 animals each (189 transplantations). The animals received 800 cGy before transplantation to the donor larynx in vivo, the donor larynx in vitro, or the recipient animal's neck. The transplantation occurred at 24 hours, 5 days, or 10 days after irradiation. The transplanted larynges were harvested 15 days after transplantation and histologically scored for rejection. Irradiation of allogeneic transplantations demonstrated a strongly protective effect from rejection as compared to no irradiation (p < .001), regardless of the method of radiation delivery or the amount of time between irradiation and transplantation (p = .78). Irradiation of donor larynges between allogeneic rats has a protective effect, reducing the degree of acute rejection when irradiation is used as the single mode of immunosuppression, and is unrelated to either the timing or the mode of delivery of the irradiation.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>12940670</pmid><doi>10.1177/000348940311200811</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0003-4894 |
| ispartof | Annals of otology, rhinology & laryngology, 2003-08, Vol.112 (8), p.712-715 |
| issn | 0003-4894 1943-572X |
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| subjects | Animals Biological and medical sciences Graft Rejection - prevention & control Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Larynx - pathology Larynx - radiation effects Larynx - transplantation Medical sciences Models, Animal Prospective Studies Radiation Dosage Rats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the upper aerodigestive tract Time Factors Transplantation Conditioning - methods Transplantation, Homologous |
| title | Immunosuppressive Effect of Irradiation in the Murine Laryngeal Transplantation Model: A Controlled Trial |
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