Design, synthesis and anticancer activity of trifluoromethylphenylamino substituted spiroindoles

[Display omitted] •Biologically active 2´-aminoanalogs and 2,2´-diaminoanalogs containing 4-trifluoromethylphenylamino group have been prepared.•The target aminoanalogs were prepared by spirocyclization protocol utilizing thioureas as starting compounds.•Prepared fluorinated aminoanalogs demonstrate...

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Veröffentlicht in:	Journal of fluorine chemistry 2018-12, Vol.216, p.24-32
Hauptverfasser:	Budovská, Mariana, Baláž, Matej, Mezencev, Roman, Tischlerová, Viera, Zigová, Martina, Mojžiš, Ján
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrochemicals Anticancer activity Anticancer properties Antitumor activity Biological activity Biotechnology Cancer Chemical synthesis Cisplatin Cytotoxicity Fibroblasts Fluorination Indoles Leukemia Phytoalexins Polymers Solid tumors Spiroindolines Toxicity Trifluoromethyl group Tumor cell lines
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