Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
Diversity-oriented synthesis has historically focused on the generation of small-molecule collections with considerable scaffold, stereochemical, and appendage diversity. Recently, this focus has begun to shift to the production of small-molecule libraries with diverse biological activities. It is c...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2019-02, Vol.17 (7), p.168-1623 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Pavlinov, Ivan Gerlach, Erica M Aldrich, Leslie N |
| description | Diversity-oriented synthesis has historically focused on the generation of small-molecule collections with considerable scaffold, stereochemical, and appendage diversity. Recently, this focus has begun to shift to the production of small-molecule libraries with diverse biological activities. It is currently not clear which properties and structural features of molecules are predictive of diverse performance in biological assays, and a better understanding of this relationship is critical for the development of performance-diverse small-molecule libraries for the discovery of novel probes for challenging targets. This review explores recent synthetic strategies for the production of bioactive small molecules and concludes with a presentation of current methods that enable the assessment of the biological performance diversity of small-molecule libraries.
Diversity-oriented synthesis adds biological performance as a new diversity element. |
| doi_str_mv | 10.1039/c8ob02327a |
| format | Article |
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| ispartof | Organic & biomolecular chemistry, 2019-02, Vol.17 (7), p.168-1623 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biodiversity Chemical synthesis Historical account Libraries Organic chemistry Performance prediction |
| title | Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity |
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