Molecular characteristics and induction profiles of hypoxia-inducible factor-1α and other basic helix–loop–helix and Per–Arnt–Sim domain-containing proteins identified in a carcinogenic liver fluke Clonorchis sinensis

Clonorchis sinensis (C. sinensis), a trematode parasite that invades the hypoxic hepatobiliary tract of vertebrate hosts requires a considerable amount of oxygen for its sexual reproduction and energy metabolism. However, little is known regarding the molecular mechanism of C. sinensis involved in t...

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Veröffentlicht in:	Parasitology 2019-02, Vol.146 (2), p.176-186
Hauptverfasser:	Kim, Seon-Hee, Oh, Gyu-Seok, Sohn, Woon-Mok, Lee, Kihyun, Yang, Hyun-Jong, Bae, Young-An
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aromatic compounds Base Sequence Carcinogens Clonorchiasis - complications Clonorchiasis - parasitology Clonorchis sinensis Clonorchis sinensis - chemistry Clonorchis sinensis - classification Clonorchis sinensis - genetics Clonorchis sinensis - metabolism Competition DNA, Complementary - chemistry Energy metabolism Enzymes Gene Expression Helix-Loop-Helix Motifs - genetics Homeostasis Humans Hydrocarbons Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - chemistry Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Infections Kinases Ligands Liver Mammals Metabolism Molecular Conformation Nitric oxide Nitric Oxide - pharmacology Nitrites - pharmacology Oxygen Parasites Parasitic diseases Phylogeny Physiology Prolyl hydroxylase Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Rats Rats, Sprague-Dawley Reproduction (biology) Respiration Sexual reproduction Vertebrates Worms
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