Trace Analysis of Antidepressant Pharmaceuticals and Their Select Degradates in Aquatic Matrixes by LC/ESI/MS/MS
Treated wastewater effluent is a potential environmental point source for antidepressant pharmaceuticals. A quantitative method was developed for the determination of trace levels of antidepressants in environmental aquatic matrixes using solid-phase extraction coupled with liquid chromatography-ele...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2008-03, Vol.80 (5), p.1756-1762 |
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| creator | Schultz, Melissa M Furlong, Edward T |
| description | Treated wastewater effluent is a potential environmental point source for antidepressant pharmaceuticals. A quantitative method was developed for the determination of trace levels of antidepressants in environmental aquatic matrixes using solid-phase extraction coupled with liquid chromatography-electrospray ionization tandem mass spectrometry. Recoveries of parent antidepressants from matrix spiking experiments for the individual antidepressants ranged from 72 to 118% at low concentrations (0.5 ng/L) and 70 to 118% at high concentrations (100 ng/L) for the solid-phase extraction method. Method detection limits for the individual antidepressant compounds ranged from 0.19 to 0.45 ng/L. The method was applied to wastewater effluent and samples collected from a wastewater-dominated stream. Venlafaxine was the predominant antidepressant observed in wastewater and river water samples. Individual antidepressant concentrations found in the wastewater effluent ranged from 3 (duloxetine) to 2190 ng/L (venlafaxine), whereas individual concentrations in the waste-dominated stream ranged from 0.72 (norfluoxetine) to 1310 ng/L (venlafaxine). |
| doi_str_mv | 10.1021/ac702154e |
| format | Article |
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A quantitative method was developed for the determination of trace levels of antidepressants in environmental aquatic matrixes using solid-phase extraction coupled with liquid chromatography-electrospray ionization tandem mass spectrometry. Recoveries of parent antidepressants from matrix spiking experiments for the individual antidepressants ranged from 72 to 118% at low concentrations (0.5 ng/L) and 70 to 118% at high concentrations (100 ng/L) for the solid-phase extraction method. Method detection limits for the individual antidepressant compounds ranged from 0.19 to 0.45 ng/L. The method was applied to wastewater effluent and samples collected from a wastewater-dominated stream. Venlafaxine was the predominant antidepressant observed in wastewater and river water samples. Individual antidepressant concentrations found in the wastewater effluent ranged from 3 (duloxetine) to 2190 ng/L (venlafaxine), whereas individual concentrations in the waste-dominated stream ranged from 0.72 (norfluoxetine) to 1310 ng/L (venlafaxine).</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac702154e</identifier><identifier>PMID: 18229944</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Analysis methods ; Analytical chemistry ; Antidepressants ; Antidepressive Agents - analysis ; Applied sciences ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography ; Chromatography, Liquid ; Drug Residues - analysis ; Effluents ; Exact sciences and technology ; Mass spectrometry ; Molecular Structure ; Natural water pollution ; Other chromatographic methods ; Pollution ; Rivers - chemistry ; Spectrometric and optical methods ; Spectrometry, Mass, Electrospray Ionization ; Waste Disposal, Fluid ; Water - chemistry ; Water Pollutants, Chemical - analysis ; Water treatment ; Water treatment and pollution</subject><ispartof>Analytical chemistry (Washington), 2008-03, Vol.80 (5), p.1756-1762</ispartof><rights>Copyright © 2008 American Chemical Society</rights><rights>2008 INIST-CNRS</rights><rights>Copyright American Chemical Society Mar 1, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a408t-ea0e543028a4831b07642a9571fd52d64a1ceb5582091d5d6827bc75b918572e3</citedby><cites>FETCH-LOGICAL-a408t-ea0e543028a4831b07642a9571fd52d64a1ceb5582091d5d6827bc75b918572e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac702154e$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac702154e$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20176212$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18229944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schultz, Melissa M</creatorcontrib><creatorcontrib>Furlong, Edward T</creatorcontrib><title>Trace Analysis of Antidepressant Pharmaceuticals and Their Select Degradates in Aquatic Matrixes by LC/ESI/MS/MS</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Treated wastewater effluent is a potential environmental point source for antidepressant pharmaceuticals. A quantitative method was developed for the determination of trace levels of antidepressants in environmental aquatic matrixes using solid-phase extraction coupled with liquid chromatography-electrospray ionization tandem mass spectrometry. Recoveries of parent antidepressants from matrix spiking experiments for the individual antidepressants ranged from 72 to 118% at low concentrations (0.5 ng/L) and 70 to 118% at high concentrations (100 ng/L) for the solid-phase extraction method. Method detection limits for the individual antidepressant compounds ranged from 0.19 to 0.45 ng/L. The method was applied to wastewater effluent and samples collected from a wastewater-dominated stream. Venlafaxine was the predominant antidepressant observed in wastewater and river water samples. Individual antidepressant concentrations found in the wastewater effluent ranged from 3 (duloxetine) to 2190 ng/L (venlafaxine), whereas individual concentrations in the waste-dominated stream ranged from 0.72 (norfluoxetine) to 1310 ng/L (venlafaxine).</description><subject>Analysis methods</subject><subject>Analytical chemistry</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - analysis</subject><subject>Applied sciences</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography</subject><subject>Chromatography, Liquid</subject><subject>Drug Residues - analysis</subject><subject>Effluents</subject><subject>Exact sciences and technology</subject><subject>Mass spectrometry</subject><subject>Molecular Structure</subject><subject>Natural water pollution</subject><subject>Other chromatographic methods</subject><subject>Pollution</subject><subject>Rivers - chemistry</subject><subject>Spectrometric and optical methods</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Waste Disposal, Fluid</subject><subject>Water - chemistry</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water treatment</subject><subject>Water treatment and pollution</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0E9r2zAYBnAxNtas22FfYIjBDjt4eSXrn48hbddCshWcsaN4LcurusRJJRuabz-VhOQwEEhIPx70PoR8ZPCNAWdTdDpvUvhXZMIkh0IZw1-TCQCUBdcAF-RdSo8AjAFTb8kFM5xXlRATsltFdJ7OelzvU0h02-XzEFq_iz4l7Ad6_4Bxk804BIfrRLFv6erBh0hrv_ZuoFf-T8QWB59o6OnsacQs6RKHGJ7zXbOni_n0ur6bLuu83pM3XY7xH477Jfl1c72a3xaLn9_v5rNFgQLMUHgEL0UJ3KAwJWtAK8Gxkpp1reStEsicb6Q0HCrWylYZrhunZVMxIzX35SX5fMjdxe3T6NNgH7djzGMmy5k2FSglMvp6QC5uU4q-s7sYNhj3loF9qdaeqs320zFwbDa-Pctjlxl8OQJMuakuYu9COjkOTCvOeHbFwYU0-OfTO8a_VulSS7u6r23940bVevnbLs-56NJ5iP8_-A9sNJmL</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Schultz, Melissa M</creator><creator>Furlong, Edward T</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>20080301</creationdate><title>Trace Analysis of Antidepressant Pharmaceuticals and Their Select Degradates in Aquatic Matrixes by LC/ESI/MS/MS</title><author>Schultz, Melissa M ; Furlong, Edward T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a408t-ea0e543028a4831b07642a9571fd52d64a1ceb5582091d5d6827bc75b918572e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis methods</topic><topic>Analytical chemistry</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - analysis</topic><topic>Applied sciences</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography</topic><topic>Chromatography, Liquid</topic><topic>Drug Residues - analysis</topic><topic>Effluents</topic><topic>Exact sciences and technology</topic><topic>Mass spectrometry</topic><topic>Molecular Structure</topic><topic>Natural water pollution</topic><topic>Other chromatographic methods</topic><topic>Pollution</topic><topic>Rivers - chemistry</topic><topic>Spectrometric and optical methods</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Waste Disposal, Fluid</topic><topic>Water - chemistry</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water treatment</topic><topic>Water treatment and pollution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schultz, Melissa M</creatorcontrib><creatorcontrib>Furlong, Edward T</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schultz, Melissa M</au><au>Furlong, Edward T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trace Analysis of Antidepressant Pharmaceuticals and Their Select Degradates in Aquatic Matrixes by LC/ESI/MS/MS</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>80</volume><issue>5</issue><spage>1756</spage><epage>1762</epage><pages>1756-1762</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>Treated wastewater effluent is a potential environmental point source for antidepressant pharmaceuticals. A quantitative method was developed for the determination of trace levels of antidepressants in environmental aquatic matrixes using solid-phase extraction coupled with liquid chromatography-electrospray ionization tandem mass spectrometry. Recoveries of parent antidepressants from matrix spiking experiments for the individual antidepressants ranged from 72 to 118% at low concentrations (0.5 ng/L) and 70 to 118% at high concentrations (100 ng/L) for the solid-phase extraction method. Method detection limits for the individual antidepressant compounds ranged from 0.19 to 0.45 ng/L. The method was applied to wastewater effluent and samples collected from a wastewater-dominated stream. Venlafaxine was the predominant antidepressant observed in wastewater and river water samples. Individual antidepressant concentrations found in the wastewater effluent ranged from 3 (duloxetine) to 2190 ng/L (venlafaxine), whereas individual concentrations in the waste-dominated stream ranged from 0.72 (norfluoxetine) to 1310 ng/L (venlafaxine).</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>18229944</pmid><doi>10.1021/ac702154e</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis methods Analytical chemistry Antidepressants Antidepressive Agents - analysis Applied sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, Liquid Drug Residues - analysis Effluents Exact sciences and technology Mass spectrometry Molecular Structure Natural water pollution Other chromatographic methods Pollution Rivers - chemistry Spectrometric and optical methods Spectrometry, Mass, Electrospray Ionization Waste Disposal, Fluid Water - chemistry Water Pollutants, Chemical - analysis Water treatment Water treatment and pollution |
| title | Trace Analysis of Antidepressant Pharmaceuticals and Their Select Degradates in Aquatic Matrixes by LC/ESI/MS/MS |
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