Screening of Nerve Agent Degradation Products by MALDI-TOFMS
A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2006-07, Vol.78 (13), p.4697-4701 |
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| creator | Shu, You-Ren Su, An-Kai Liu, Ju-Tsung Lin, Cheng-Huang |
| description | A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and cyclohexyl methylphosphonic acid (CHMPA), which are degradation products of Sarin (GB), Soman (GD), VX, Russian VX (RVX), and GF, respectively. For comparison, CHCA (α-cyano-4-hydroxycinnamic acid) and DCCA (7-(diethylamino)coumarin-3-carboxylic acid) were used as the MALDI-matrix when the third harmonic generation (355 nm) of a Nd:YAG laser and a hydrogen Raman laser (multifrequency laser) were used, respectively. The method permitted the five nerve agent degradation products to be screened rapidly and successfully, suggesting that it has the potential for use as a routine monitoring tool. |
| doi_str_mv | 10.1021/ac060007k |
| format | Article |
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Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and cyclohexyl methylphosphonic acid (CHMPA), which are degradation products of Sarin (GB), Soman (GD), VX, Russian VX (RVX), and GF, respectively. For comparison, CHCA (α-cyano-4-hydroxycinnamic acid) and DCCA (7-(diethylamino)coumarin-3-carboxylic acid) were used as the MALDI-matrix when the third harmonic generation (355 nm) of a Nd:YAG laser and a hydrogen Raman laser (multifrequency laser) were used, respectively. 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Chem</addtitle><description>A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and cyclohexyl methylphosphonic acid (CHMPA), which are degradation products of Sarin (GB), Soman (GD), VX, Russian VX (RVX), and GF, respectively. For comparison, CHCA (α-cyano-4-hydroxycinnamic acid) and DCCA (7-(diethylamino)coumarin-3-carboxylic acid) were used as the MALDI-matrix when the third harmonic generation (355 nm) of a Nd:YAG laser and a hydrogen Raman laser (multifrequency laser) were used, respectively. The method permitted the five nerve agent degradation products to be screened rapidly and successfully, suggesting that it has the potential for use as a routine monitoring tool.</description><subject>Analytical chemistry</subject><subject>Biological & chemical weapons</subject><subject>Central Nervous System - drug effects</subject><subject>Chemical Warfare Agents - analysis</subject><subject>Chemical Warfare Agents - toxicity</subject><subject>Chemistry</subject><subject>Environmental monitoring</subject><subject>Exact sciences and technology</subject><subject>Lasers</subject><subject>Spectrometric and optical methods</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><subject>Spectrum analysis</subject><subject>Toxins</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0MtKAzEUBuAgitbLwheQQXDhYvQkk8kF3NRLVWxtoVWXIZM5U6bVGU2mom_vSItduAokH_85-Qk5pHBGgdFz60AAgJxvkA5NGcRCKbZJOu1dEjMJsEN2Q5gBUApUbJMdKhQorniHXIydR6zKahrVRfSI_hOj7hSrJrrGqbe5bcq6ika-zheuCVH2HQ26_ev7eDLsDcb7ZKuwrwEPVuceeerdTK7u4v7w9v6q248tB9XECWiep5kUIDFxGTLFuVMM81xpKhOdaS25RYap45IXDvK0cKLQLlWY5pgke-R4mfvu648FhsbM6oWv2pGGUamUElK06HSJnK9D8FiYd1--Wf9tKJjfmsxfTa09WgUusjfM13LVSwtOVsAGZ18LbytXhrWTOtFK_Lp46crQ4Nffu_VzI2QiUzMZjc3lg-69sPGzGa1zrQvrT_xf8AePa4ef</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Shu, You-Ren</creator><creator>Su, An-Kai</creator><creator>Liu, Ju-Tsung</creator><creator>Lin, Cheng-Huang</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>20060701</creationdate><title>Screening of Nerve Agent Degradation Products by MALDI-TOFMS</title><author>Shu, You-Ren ; Su, An-Kai ; Liu, Ju-Tsung ; Lin, Cheng-Huang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a408t-3094d5b7607e3cbe2844c82edd891739b9974ae2e5c474fc0d5fc6f9c58e5de33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analytical chemistry</topic><topic>Biological & chemical weapons</topic><topic>Central Nervous System - drug effects</topic><topic>Chemical Warfare Agents - analysis</topic><topic>Chemical Warfare Agents - toxicity</topic><topic>Chemistry</topic><topic>Environmental monitoring</topic><topic>Exact sciences and technology</topic><topic>Lasers</topic><topic>Spectrometric and optical methods</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><topic>Spectrum analysis</topic><topic>Toxins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shu, You-Ren</creatorcontrib><creatorcontrib>Su, An-Kai</creatorcontrib><creatorcontrib>Liu, Ju-Tsung</creatorcontrib><creatorcontrib>Lin, Cheng-Huang</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shu, You-Ren</au><au>Su, An-Kai</au><au>Liu, Ju-Tsung</au><au>Lin, Cheng-Huang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening of Nerve Agent Degradation Products by MALDI-TOFMS</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>78</volume><issue>13</issue><spage>4697</spage><epage>4701</epage><pages>4697-4701</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid (IMPA), pinacolyl methylphosphonic acid (PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and cyclohexyl methylphosphonic acid (CHMPA), which are degradation products of Sarin (GB), Soman (GD), VX, Russian VX (RVX), and GF, respectively. 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| subjects | Analytical chemistry Biological & chemical weapons Central Nervous System - drug effects Chemical Warfare Agents - analysis Chemical Warfare Agents - toxicity Chemistry Environmental monitoring Exact sciences and technology Lasers Spectrometric and optical methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrum analysis Toxins |
| title | Screening of Nerve Agent Degradation Products by MALDI-TOFMS |
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