Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Analysis of low molecular weight compounds with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been developed by using carbon nanotubes obtained from coal by arc discharge as the matrix. The carbon nanotube matrix functions as substrate to trap analyte...
Gespeichert in:
| Veröffentlicht in: | Analytical chemistry (Washington) 2003-11, Vol.75 (22), p.6191-6195 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6195 |
|---|---|
| container_issue | 22 |
| container_start_page | 6191 |
| container_title | Analytical chemistry (Washington) |
| container_volume | 75 |
| creator | Xu, Songyun Li, Yongfeng Zou, Hanfa Qiu, Jieshan Guo, Zhong Guo, Baochuan |
| description | Analysis of low molecular weight compounds with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been developed by using carbon nanotubes obtained from coal by arc discharge as the matrix. The carbon nanotube matrix functions as substrate to trap analytes of peptides, organic compounds, and β-cyclodextrin deposited on its surface. It has been found that carbon nanotubes can transfer energy to the analyte under laser irradiation, which makes analytes well desorbed/ionized, and the interference of intrinsic matrix ions can be eliminated. At the same time, the fragmentation of the analyte can be avoided. A good sensitivity and excellent reproducibility of the spectrum signals are achieved. It is believed that this work not only will open a new field for applications of carbon nanotubes, but also will offer a new technique for high-speed analysis of low molecular weight compounds in areas such as metabolism research and characterization of natural products. |
| doi_str_mv | 10.1021/ac0345695 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_217880993</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>543596331</sourcerecordid><originalsourceid>FETCH-LOGICAL-a472t-2d57d1fc92e70178544b7af54b672f655c3f5e2434100273b8f940d50dfbbbe93</originalsourceid><addsrcrecordid>eNpl0M1uEzEUBWALUdFQWPACyEJiwWLa6_-ZZZtSqBhoRcPasmdsmJKMg68jtTw9EyVqFqxs6X4-tg8hbxicMuDszHUgpNKNekZmTHGodF3z52QGAKLiBuCYvES8B2AMmH5BjpnUTE_TGennLvs00m9uTGXjA1KH9BxxwBJ6-tWVPDzQmDJtHYZMLwOmvC5DGs-u0zj8ddstXQyrUKVYXS2Hn7_KdAqR3q1DV3JahZIfX5Gj6JYYXu_XE_Lj6uNi_rlqbz5dz8_byknDS8V7ZXoWu4YHA8zUSkpvXFTSa8OjVqoTUQUuhWQA3Ahfx0ZCr6CP3vvQiBPybpe7zunPJmCx92mTx-lKy6e8GppGTOjDDnU5IeYQ7ToPK5cfLQO7rdM-1TnZt_vAjV-F_iD3_U3g_R447NwyZjd2Ax6cEqC0YJOrdm7b68PT3OXfVhthlF3c3lkQ5vJLe9Ha74dc1-HhE_8_8B8erJZz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217880993</pqid></control><display><type>article</type><title>Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Xu, Songyun ; Li, Yongfeng ; Zou, Hanfa ; Qiu, Jieshan ; Guo, Zhong ; Guo, Baochuan</creator><creatorcontrib>Xu, Songyun ; Li, Yongfeng ; Zou, Hanfa ; Qiu, Jieshan ; Guo, Zhong ; Guo, Baochuan</creatorcontrib><description>Analysis of low molecular weight compounds with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been developed by using carbon nanotubes obtained from coal by arc discharge as the matrix. The carbon nanotube matrix functions as substrate to trap analytes of peptides, organic compounds, and β-cyclodextrin deposited on its surface. It has been found that carbon nanotubes can transfer energy to the analyte under laser irradiation, which makes analytes well desorbed/ionized, and the interference of intrinsic matrix ions can be eliminated. At the same time, the fragmentation of the analyte can be avoided. A good sensitivity and excellent reproducibility of the spectrum signals are achieved. It is believed that this work not only will open a new field for applications of carbon nanotubes, but also will offer a new technique for high-speed analysis of low molecular weight compounds in areas such as metabolism research and characterization of natural products.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac0345695</identifier><identifier>PMID: 14616000</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Analytical chemistry ; beta-Cyclodextrins ; Carbon ; Chemistry ; Cyclodextrins - chemistry ; Desorption ; Exact sciences and technology ; Ions ; Lasers ; Matrix ; Molecular Weight ; Nanotubes ; Nanotubes, Carbon - ultrastructure ; Organic Chemicals - chemistry ; Peptides - chemistry ; Reproducibility of Results ; Sensitivity and Specificity ; Spectrometric and optical methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods ; Spectrum analysis</subject><ispartof>Analytical chemistry (Washington), 2003-11, Vol.75 (22), p.6191-6195</ispartof><rights>Copyright © 2003 American Chemical Society</rights><rights>2004 INIST-CNRS</rights><rights>Copyright American Chemical Society Nov 15, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a472t-2d57d1fc92e70178544b7af54b672f655c3f5e2434100273b8f940d50dfbbbe93</citedby><cites>FETCH-LOGICAL-a472t-2d57d1fc92e70178544b7af54b672f655c3f5e2434100273b8f940d50dfbbbe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac0345695$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac0345695$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15305631$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14616000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Songyun</creatorcontrib><creatorcontrib>Li, Yongfeng</creatorcontrib><creatorcontrib>Zou, Hanfa</creatorcontrib><creatorcontrib>Qiu, Jieshan</creatorcontrib><creatorcontrib>Guo, Zhong</creatorcontrib><creatorcontrib>Guo, Baochuan</creatorcontrib><title>Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Analysis of low molecular weight compounds with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been developed by using carbon nanotubes obtained from coal by arc discharge as the matrix. The carbon nanotube matrix functions as substrate to trap analytes of peptides, organic compounds, and β-cyclodextrin deposited on its surface. It has been found that carbon nanotubes can transfer energy to the analyte under laser irradiation, which makes analytes well desorbed/ionized, and the interference of intrinsic matrix ions can be eliminated. At the same time, the fragmentation of the analyte can be avoided. A good sensitivity and excellent reproducibility of the spectrum signals are achieved. It is believed that this work not only will open a new field for applications of carbon nanotubes, but also will offer a new technique for high-speed analysis of low molecular weight compounds in areas such as metabolism research and characterization of natural products.</description><subject>Analytical chemistry</subject><subject>beta-Cyclodextrins</subject><subject>Carbon</subject><subject>Chemistry</subject><subject>Cyclodextrins - chemistry</subject><subject>Desorption</subject><subject>Exact sciences and technology</subject><subject>Ions</subject><subject>Lasers</subject><subject>Matrix</subject><subject>Molecular Weight</subject><subject>Nanotubes</subject><subject>Nanotubes, Carbon - ultrastructure</subject><subject>Organic Chemicals - chemistry</subject><subject>Peptides - chemistry</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spectrometric and optical methods</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><subject>Spectrum analysis</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpl0M1uEzEUBWALUdFQWPACyEJiwWLa6_-ZZZtSqBhoRcPasmdsmJKMg68jtTw9EyVqFqxs6X4-tg8hbxicMuDszHUgpNKNekZmTHGodF3z52QGAKLiBuCYvES8B2AMmH5BjpnUTE_TGennLvs00m9uTGXjA1KH9BxxwBJ6-tWVPDzQmDJtHYZMLwOmvC5DGs-u0zj8ddstXQyrUKVYXS2Hn7_KdAqR3q1DV3JahZIfX5Gj6JYYXu_XE_Lj6uNi_rlqbz5dz8_byknDS8V7ZXoWu4YHA8zUSkpvXFTSa8OjVqoTUQUuhWQA3Ahfx0ZCr6CP3vvQiBPybpe7zunPJmCx92mTx-lKy6e8GppGTOjDDnU5IeYQ7ToPK5cfLQO7rdM-1TnZt_vAjV-F_iD3_U3g_R447NwyZjd2Ax6cEqC0YJOrdm7b68PT3OXfVhthlF3c3lkQ5vJLe9Ha74dc1-HhE_8_8B8erJZz</recordid><startdate>20031115</startdate><enddate>20031115</enddate><creator>Xu, Songyun</creator><creator>Li, Yongfeng</creator><creator>Zou, Hanfa</creator><creator>Qiu, Jieshan</creator><creator>Guo, Zhong</creator><creator>Guo, Baochuan</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>20031115</creationdate><title>Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry</title><author>Xu, Songyun ; Li, Yongfeng ; Zou, Hanfa ; Qiu, Jieshan ; Guo, Zhong ; Guo, Baochuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a472t-2d57d1fc92e70178544b7af54b672f655c3f5e2434100273b8f940d50dfbbbe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Analytical chemistry</topic><topic>beta-Cyclodextrins</topic><topic>Carbon</topic><topic>Chemistry</topic><topic>Cyclodextrins - chemistry</topic><topic>Desorption</topic><topic>Exact sciences and technology</topic><topic>Ions</topic><topic>Lasers</topic><topic>Matrix</topic><topic>Molecular Weight</topic><topic>Nanotubes</topic><topic>Nanotubes, Carbon - ultrastructure</topic><topic>Organic Chemicals - chemistry</topic><topic>Peptides - chemistry</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spectrometric and optical methods</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Songyun</creatorcontrib><creatorcontrib>Li, Yongfeng</creatorcontrib><creatorcontrib>Zou, Hanfa</creatorcontrib><creatorcontrib>Qiu, Jieshan</creatorcontrib><creatorcontrib>Guo, Zhong</creatorcontrib><creatorcontrib>Guo, Baochuan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Songyun</au><au>Li, Yongfeng</au><au>Zou, Hanfa</au><au>Qiu, Jieshan</au><au>Guo, Zhong</au><au>Guo, Baochuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2003-11-15</date><risdate>2003</risdate><volume>75</volume><issue>22</issue><spage>6191</spage><epage>6195</epage><pages>6191-6195</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>Analysis of low molecular weight compounds with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been developed by using carbon nanotubes obtained from coal by arc discharge as the matrix. The carbon nanotube matrix functions as substrate to trap analytes of peptides, organic compounds, and β-cyclodextrin deposited on its surface. It has been found that carbon nanotubes can transfer energy to the analyte under laser irradiation, which makes analytes well desorbed/ionized, and the interference of intrinsic matrix ions can be eliminated. At the same time, the fragmentation of the analyte can be avoided. A good sensitivity and excellent reproducibility of the spectrum signals are achieved. It is believed that this work not only will open a new field for applications of carbon nanotubes, but also will offer a new technique for high-speed analysis of low molecular weight compounds in areas such as metabolism research and characterization of natural products.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>14616000</pmid><doi>10.1021/ac0345695</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2700 |
| ispartof | Analytical chemistry (Washington), 2003-11, Vol.75 (22), p.6191-6195 |
| issn | 0003-2700 1520-6882 |
| language | eng |
| recordid | cdi_proquest_journals_217880993 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Analytical chemistry beta-Cyclodextrins Carbon Chemistry Cyclodextrins - chemistry Desorption Exact sciences and technology Ions Lasers Matrix Molecular Weight Nanotubes Nanotubes, Carbon - ultrastructure Organic Chemicals - chemistry Peptides - chemistry Reproducibility of Results Sensitivity and Specificity Spectrometric and optical methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectrum analysis |
| title | Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T18%3A28%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carbon%20Nanotubes%20as%20Assisted%20Matrix%20for%20Laser%20Desorption/Ionization%20Time-of-Flight%20Mass%20Spectrometry&rft.jtitle=Analytical%20chemistry%20(Washington)&rft.au=Xu,%20Songyun&rft.date=2003-11-15&rft.volume=75&rft.issue=22&rft.spage=6191&rft.epage=6195&rft.pages=6191-6195&rft.issn=0003-2700&rft.eissn=1520-6882&rft.coden=ANCHAM&rft_id=info:doi/10.1021/ac0345695&rft_dat=%3Cproquest_cross%3E543596331%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217880993&rft_id=info:pmid/14616000&rfr_iscdi=true |