Electrochemiluminescence-Based Detection of β-Lactam Antibiotics and β-Lactamases

Bacterial resistance to clinically administered β-lactam antibiotics is usually caused by β-lactamases, enzymes that hydrolytically inactivate the antibiotics. This paper describes the use of electrogenerated chemiluminescence (ECL) to detect β-lactam antibiotics and their hydrolysis by β-lactamases...

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