Comparative study in the Ames test of benzo[a]pyrene and 2‐aminoanthracene metabolic activation using rat hepatic S9 and hepatocytes following in vivo or in vitro induction

We studied the replacement of hepatic S9 with in vivo and in vitro induced hepatocytes as a metabolic activation system with the aim of broadening the possibilities of mutagenic assays. Rats were pretreated with β‐naphthoflavone (BNF), phenobarbital (PB), 3‐methylcholanthrene (MC) and a combination...

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Veröffentlicht in:	Mutagenesis 2004-05, Vol.19 (3), p.245-250
Hauptverfasser:	Jemnitz, Katalin, Veres, Zsuzsa, Torok, Geza, Toth, Eva, Vereczkey, Laszlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracenes - pharmacology Benzo(a)pyrene - pharmacology Biological and medical sciences Carcinogens - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Hepatocytes - drug effects Male Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutagenicity Tests Mutagens - pharmacology Rats Rats, Wistar
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