Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside

A new synthetic drug, benzamide riboside (BR) exhibited strong oncolytic activity against leukemic cells in the 5–10 μM range. Higher BR-concentrations (20 μM) predominantly induced necrosis which correlated with DNA strand breaks and subsequent depletion of ATP- and dATP levels. Replenishment of th...

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Veröffentlicht in:	Cell death and differentiation 2002-02, Vol.9 (2), p.169-178
Hauptverfasser:	Grusch, M, Polgar, D, Gfatter, S, Leuhuber, K, Huettenbrenner, S, Leisser, C, Fuhrmann, G, Kassie, F, Steinkellner, H, Smid, K, Peters, G J, Jayaram, H N, Klepal, W, Szekeres, T, Knasmüller, S, Krupitza, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adenosine - pharmacology Adenosine triphosphate Adenosine Triphosphate - analysis Adenosine Triphosphate - physiology Antineoplastic Agents - toxicity Apoptosis Benzamides - pharmacology Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Chemotherapy Comet Assay Dehydrogenases Deoxyadenine Nucleotides - analysis Deoxycytosine Nucleotides - analysis Deoxyribonucleotides - analysis DNA Damage Dose-Response Relationship, Drug Drug dosages Enzyme Inhibitors - pharmacology Enzymes HL-60 Cells Humans IMP Dehydrogenase - antagonists & inhibitors Leukemia Life Sciences Necrosis Nucleosides - toxicity Oncology original-paper Poly(ADP-ribose) Polymerase Inhibitors Potassium Cyanide - antagonists & inhibitors Stem Cells Toxicity Tretinoin - antagonists & inhibitors
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