Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes

Erythrocytes lack nuclei and mitochondria, the organelles important for apoptosis of nucleated cells. However, following increase of cytosolic Ca 2+ activity, erythrocytes undergo cell shrinkage, cell membrane blebbing and breakdown of phosphatidylserine asymmetry, all features typical for apoptosis...

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Veröffentlicht in:	Cell death and differentiation 2004-02, Vol.11 (2), p.231-243
Hauptverfasser:	Lang, K S, Myssina, S, Brand, V, Sandu, C, Lang, P A, Berchtold, S, Huber, S M, Lang, F, Wieder, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexins - metabolism Apoptosis Asymmetry Biochemistry Biomedical and Life Sciences Calcium - metabolism Caspases - metabolism Cell Biology Cell Cycle Analysis Cell death Cell Death - drug effects Cell Size - drug effects Ceramides - biosynthesis Ceramides - metabolism Ceramides - pharmacology Coumarins - pharmacology Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Fumonisins - pharmacology Humans Ionomycin - pharmacology Kinases Life Sciences Mice Mice, Knockout Mitochondria original-paper Osmotic Pressure - drug effects Protein Binding - drug effects Sphingomyelin Phosphodiesterase - antagonists & inhibitors Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism Sphingomyelins - metabolism Stem Cells Tumor necrosis factor-TNF
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