Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses

Specific types of human papillomaviruses (HPVs) cause cervical cancer, the second most common tumor in women worldwide. Both cellular transformation and the maintenance of the oncogenic phenotype of HPV-positive tumor cells are linked to the expression of the viral E6 and E7 oncogenes. To identify d...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2007-11, Vol.85 (11), p.1253-1262
Hauptverfasser:	KUNER, Ruprecht, VOGT, Markus, SULTMANN, Holger, BUNESS, Andreas, DYMALLA, Susanne, BULKESCHER, Julia, FELLMANN, Mark, BUTZ, Karin, POUSTKA, Annemarie, HOPPE-SEYLER, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Cycle - drug effects Cluster Analysis DNA-Binding Proteins - genetics Female Female genital diseases Gene Expression Profiling Gene Expression Regulation, Viral - drug effects Gene Regulatory Networks General aspects Gynecology. Andrology. Obstetrics HeLa Cells Human papillomavirus 18 - genetics Humans Medical sciences Oncogene Proteins, Viral - genetics Repressor Proteins - metabolism RNA Interference RNA Processing, Post-Transcriptional - drug effects RNA, Small Interfering - pharmacology Tumors Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology
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