Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases

Mouse hippocampal glutamatergic nerve endings express presynaptic release-regulating NMDA autoreceptors (NMDARs). The presence of GluN1, GluN2A, GluN2B, and GluN3A subunits in hippocampal vesicular glutamate transporter type 1-positive synaptosomes was confirmed with confocal microscopy. GluN2C, Glu...

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Veröffentlicht in:	Molecular neurobiology 2019-09, Vol.56 (9), p.6142-6155
Hauptverfasser:	Olivero, Guendalina, Vergassola, Matteo, Cisani, Francesca, Usai, Cesare, Pittaluga, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies - pharmacology Aspartic Acid - metabolism Auditory evoked potentials Autoimmune diseases Autoimmune Diseases - immunology Biomedical and Life Sciences Biomedicine Biotinylation Cell Biology Confocal microscopy Dizocilpine Glutamatergic transmission Glutamic Acid - metabolism Glutamic acid receptors (ionotropic) Glutamic acid transporter Glycine Hippocampus Hippocampus - metabolism Hydrogen-Ion Concentration Internalization Membranes Mice, Inbred C57BL Microscopy N-Methyl-D-aspartic acid receptors Nerve endings Neurobiology Neurology Neurosciences Overflow Plasma membranes Potassium Chloride - pharmacology Presynaptic Terminals - metabolism Protein Subunits - metabolism Proteins Protons Receptors, N-Methyl-D-Aspartate - metabolism Synaptosomes Synaptosomes - metabolism Tritium - metabolism
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