Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients

Administration of specific drugs may occasionally induce acquired long QT syndrome (aLQTS), a disorder that predisposes to ventricular arrhythmias, typically of the torsade de pointes (TdP) type, and sudden cardiac death. "Forme fruste" mutations in congenital LQTS (cLQTS) genes have been...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2004-03, Vol.82 (3), p.182-188
Hauptverfasser:	Paulussen, Aimée D C, Gilissen, Ronaldus A H J, Armstrong, Martin, Doevendans, Pieter A, Verhasselt, Peter, Smeets, Hubert J M, Schulze-Bahr, Eric, Haverkamp, Wilhelm, Breithardt, Günter, Cohen, Nadine, Aerssens, Jeroen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over DNA Mutational Analysis ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels Female Genetic Variation Humans KCNQ Potassium Channels KCNQ1 Potassium Channel Long QT Syndrome - chemically induced Long QT Syndrome - etiology Long QT Syndrome - genetics Male Middle Aged Models, Genetic Mutation Mutation, Missense NAV1.5 Voltage-Gated Sodium Channel Potassium Channels - genetics Potassium Channels, Voltage-Gated Risk Factors Sodium Channels - genetics
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