Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway

Unconjugated bilirubin (UCB) is the major degradation product of the heme catabolism. A growing body of evidences suggests that UCB plays major biological effects by inhibiting cell proliferation in cancer cell lines and eliciting cell toxicity particularly in neurons and glial cells. Early molecula...

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