Study of the IR Spectra of the Saliva of Cancer Patients
Feasibility has been demonstrated in principle for the diagnosis of lung and breast cancer by subjecting saliva to Fourier transform IR spectroscopy. Statistically significant differences in the saliva of lung cancer patients are seen at 1070–1240 cm –1 , while significant differences are seen throu...
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| Veröffentlicht in: | Journal of applied spectroscopy 2019-01, Vol.85 (6), p.1076-1084 |
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| container_title | Journal of applied spectroscopy |
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| creator | Bel’skaya, L. V. Sarf, E. A. Gundyrev, I. A. |
| description | Feasibility has been demonstrated in principle for the diagnosis of lung and breast cancer by subjecting saliva to Fourier transform IR spectroscopy. Statistically significant differences in the saliva of lung cancer patients are seen at 1070–1240 cm
–1
, while significant differences are seen throughout the entire range for breast cancer patients. The I
1398/1454
and I
1240/1310
ratios were determined and found to be statistically reliable for detecting cancer pathology. Correlations were found for the intensities of the absorption bands in these IR spectra with nonspecific biochemical saliva parameters, which generally characterize greater intoxication as well as suppression of the systems for antioxidant protection and the immune response. A promising research trend involves the use of the IR spectroscopy of saliva for monitoring treatment and cancer recurrence. |
| doi_str_mv | 10.1007/s10812-019-00762-z |
| format | Article |
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–1
, while significant differences are seen throughout the entire range for breast cancer patients. The I
1398/1454
and I
1240/1310
ratios were determined and found to be statistically reliable for detecting cancer pathology. Correlations were found for the intensities of the absorption bands in these IR spectra with nonspecific biochemical saliva parameters, which generally characterize greater intoxication as well as suppression of the systems for antioxidant protection and the immune response. A promising research trend involves the use of the IR spectroscopy of saliva for monitoring treatment and cancer recurrence.</description><identifier>ISSN: 0021-9037</identifier><identifier>EISSN: 1573-8647</identifier><identifier>DOI: 10.1007/s10812-019-00762-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Absorption spectra ; Analytical Chemistry ; Antioxidants ; Atomic/Molecular Structure and Spectra ; Breast cancer ; Cancer ; Feasibility studies ; Fourier transforms ; Immune system ; Infrared spectroscopy ; Intoxication ; Patients ; Physics ; Physics and Astronomy ; Saliva ; Spectrum analysis</subject><ispartof>Journal of applied spectroscopy, 2019-01, Vol.85 (6), p.1076-1084</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-27dd61de736e07d5e88a02d40e6df2fa257203eef9ceaebdddce3b52f52f14193</citedby><cites>FETCH-LOGICAL-c319t-27dd61de736e07d5e88a02d40e6df2fa257203eef9ceaebdddce3b52f52f14193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10812-019-00762-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10812-019-00762-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Bel’skaya, L. V.</creatorcontrib><creatorcontrib>Sarf, E. A.</creatorcontrib><creatorcontrib>Gundyrev, I. A.</creatorcontrib><title>Study of the IR Spectra of the Saliva of Cancer Patients</title><title>Journal of applied spectroscopy</title><addtitle>J Appl Spectrosc</addtitle><description>Feasibility has been demonstrated in principle for the diagnosis of lung and breast cancer by subjecting saliva to Fourier transform IR spectroscopy. Statistically significant differences in the saliva of lung cancer patients are seen at 1070–1240 cm
–1
, while significant differences are seen throughout the entire range for breast cancer patients. The I
1398/1454
and I
1240/1310
ratios were determined and found to be statistically reliable for detecting cancer pathology. Correlations were found for the intensities of the absorption bands in these IR spectra with nonspecific biochemical saliva parameters, which generally characterize greater intoxication as well as suppression of the systems for antioxidant protection and the immune response. A promising research trend involves the use of the IR spectroscopy of saliva for monitoring treatment and cancer recurrence.</description><subject>Absorption spectra</subject><subject>Analytical Chemistry</subject><subject>Antioxidants</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Feasibility studies</subject><subject>Fourier transforms</subject><subject>Immune system</subject><subject>Infrared spectroscopy</subject><subject>Intoxication</subject><subject>Patients</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Saliva</subject><subject>Spectrum analysis</subject><issn>0021-9037</issn><issn>1573-8647</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LAzEQxYMoWKtfwNOC5-hM0t1kj1L8UygoVs8h3Uy0pe7WJBXaT2_sKt6EgeEN772BH2PnCJcIoK4igkbBAWueZSX47oANsFSS62qkDtkAQCCvQapjdhLjEgBqLWDA9Cxt3LbofJHeqJg8FbM1NSnY38vMrhafezW2bUOheLRpQW2Kp-zI21Wks589ZC-3N8_jez59uJuMr6e8kVgnLpRzFTpSsiJQriStLQg3AqqcF96KUgmQRL5uyNLcOdeQnJfC58ER1nLILvredeg-NhSTWXab0OaXRqCqlNK6LLNL9K4mdDEG8mYdFu82bA2C-SZkekImEzJ7QmaXQ7IPxWxuXyn8Vf-T-gJsc2iD</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Bel’skaya, L. V.</creator><creator>Sarf, E. A.</creator><creator>Gundyrev, I. A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190101</creationdate><title>Study of the IR Spectra of the Saliva of Cancer Patients</title><author>Bel’skaya, L. V. ; Sarf, E. A. ; Gundyrev, I. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-27dd61de736e07d5e88a02d40e6df2fa257203eef9ceaebdddce3b52f52f14193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Absorption spectra</topic><topic>Analytical Chemistry</topic><topic>Antioxidants</topic><topic>Atomic/Molecular Structure and Spectra</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Feasibility studies</topic><topic>Fourier transforms</topic><topic>Immune system</topic><topic>Infrared spectroscopy</topic><topic>Intoxication</topic><topic>Patients</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Saliva</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bel’skaya, L. V.</creatorcontrib><creatorcontrib>Sarf, E. A.</creatorcontrib><creatorcontrib>Gundyrev, I. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of applied spectroscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bel’skaya, L. V.</au><au>Sarf, E. A.</au><au>Gundyrev, I. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of the IR Spectra of the Saliva of Cancer Patients</atitle><jtitle>Journal of applied spectroscopy</jtitle><stitle>J Appl Spectrosc</stitle><date>2019-01-01</date><risdate>2019</risdate><volume>85</volume><issue>6</issue><spage>1076</spage><epage>1084</epage><pages>1076-1084</pages><issn>0021-9037</issn><eissn>1573-8647</eissn><abstract>Feasibility has been demonstrated in principle for the diagnosis of lung and breast cancer by subjecting saliva to Fourier transform IR spectroscopy. Statistically significant differences in the saliva of lung cancer patients are seen at 1070–1240 cm
–1
, while significant differences are seen throughout the entire range for breast cancer patients. The I
1398/1454
and I
1240/1310
ratios were determined and found to be statistically reliable for detecting cancer pathology. Correlations were found for the intensities of the absorption bands in these IR spectra with nonspecific biochemical saliva parameters, which generally characterize greater intoxication as well as suppression of the systems for antioxidant protection and the immune response. A promising research trend involves the use of the IR spectroscopy of saliva for monitoring treatment and cancer recurrence.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10812-019-00762-z</doi><tpages>9</tpages></addata></record> |
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| subjects | Absorption spectra Analytical Chemistry Antioxidants Atomic/Molecular Structure and Spectra Breast cancer Cancer Feasibility studies Fourier transforms Immune system Infrared spectroscopy Intoxication Patients Physics Physics and Astronomy Saliva Spectrum analysis |
| title | Study of the IR Spectra of the Saliva of Cancer Patients |
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