Identification, molecular characterization, and structural analysis of the bla NDM-1 gene/enzyme from NDM-1-producing Klebsiella pneumoniae isolates

NDM-1 comprises a carbapenemase that was first detected in 2008 in New Delhi, India. Since then, NDM-1-producing Klebsiella pneumoniae strains have been reported in many countries and usually associated with intra and inter-hospital dissemination, along with travel-related epidemiological links. In...

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Veröffentlicht in:	Journal of antibiotics 2019-03, Vol.72 (3), p.155-163
Hauptverfasser:	Melgarejo, Jhessyca Leal, Cardoso, Marlon Henrique, Pinto, Ingrid Batista, Faria-Junior, Célio, Mendo, Sónia, de Oliveira, Carina Elisei, Franco, Octavio Luiz
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotics beta-Lactam Resistance beta-Lactamases - chemistry beta-Lactamases - genetics Bioinformatics Brazil Carbapenems - metabolism Carbapenems - pharmacology Cloning, Molecular Computational Biology Conserved Sequence Enzymes Genotype Hospitals Humans Klebsiella Infections - microbiology Klebsiella pneumoniae - classification Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Microbial Sensitivity Tests Molecular Docking Simulation Molecular Typing Protein Binding Structural analysis
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