Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Osteoarthritis is the most common musculoskeletal disease and the leading cause of disability globally. Here, we performed a genome-wide association study for osteoarthritis (77,052 cases and 378,169 controls), analyzing four phenotypes: knee osteoarthritis, hip osteoarthritis, knee and/or hip osteo...

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Veröffentlicht in:	Nature genetics 2019-02, Vol.51 (2), p.230-236
Hauptverfasser:	Tachmazidou, Ioanna, Hatzikotoulas, Konstantinos, Southam, Lorraine, Esparza-Gordillo, Jorge, Haberland, Valeriia, Zheng, Jie, Johnson, Toby, Koprulu, Mine, Zengini, Eleni, Steinberg, Julia, Wilkinson, Jeremy M., Bhatnagar, Sahir, Hoffman, Joshua D., Buchan, Natalie, Süveges, Dániel, Yerges-Armstrong, Laura, Smith, George Davey, Gaunt, Tom R., Scott, Robert A., McCarthy, Linda C., Zeggini, Eleftheria
Format:	Artikel
Sprache:	eng
Schlagworte:	38/91 45/43 631/208 631/208/205 631/208/205/2138 82/58 Adult Aged Agriculture Animal diseases Animal Genetics and Genomics Arthritis Biocompatibility Bioinformatics Biological Specimen Banks Biomedical and Life Sciences Biomedicine Body mass index Cancer Research Case-Control Studies Cathepsin K Clinical trials Collagen Disease Extracellular matrix Female Fibroblast growth factor 18 Gene expression Gene Function Gene mapping Genes Genetic Predisposition to Disease - genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Growth factors Hip Human Genetics Humans Interleukin 1 Interleukin 11 Interleukins Joint replacement surgery Knee Letter Male Mapping Medical research Middle Aged Musculoskeletal diseases Osteoarthritis Osteoarthritis, Hip - genetics Pain Phenotypes Polymorphism, Single Nucleotide - genetics Quantitative trait loci Quantitative Trait Loci - genetics Studies Target recognition Therapeutic applications Transforming growth factor-b1 United Kingdom
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