Stimuli-responsive multifunctional metal-organic framework nanoparticles for enhanced chemo-photothermal therapy
Construction of stimuli-responsive multifunctional nanoparticles is critical for nanotherapeutic delivery. Though metal-organic frameworks (MOFs) have been emerged as promising delivery vehicles, the therapeutic efficacy of MOFs in cancer treatment is limited by the lack of a general approach for th...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-02, Vol.7 (6), p.994-14 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Feng, Jie Xu, Zhen Dong, Ping Yu, Wenqian Liu, Feng Jiang, Qunying Wang, Fuan Liu, Xiaoqing |
| description | Construction of stimuli-responsive multifunctional nanoparticles is critical for nanotherapeutic delivery. Though metal-organic frameworks (MOFs) have been emerged as promising delivery vehicles, the therapeutic efficacy of MOFs in cancer treatment is limited by the lack of a general approach for the preparation of stimuli-responsive multifunctional MOFs. We show that the combination of a versatile coating material polydopamine with MOFs enables facile integration of different functional therapeutics, obtaining stimuli-responsive multifunctional MOFs with extensive photothermal efficiency and outstanding capability to abrogate tumors by chemo-photothermal therapy. Exemplary MOFs including ZIF-8, UiO-66, and MIL-101 were utilized to prepare stimuli-responsive multifunctional MOFs to illustrate the generality of the strategy. This approach enables targeted drug delivery and stimuli-responsive release of multi-therapeutics and allows combination therapy with excellent
in vitro
and
in vivo
antitumor activity. Taking into account the diversity of MOFs and different functional molecules, this work provides flexible access to programmable MOF nanoparticles for specific biological applications.
Programmable metal-organic frameworks were prepared as efficient delivery vehicles for targeted and stimuli-responsive release of multi-therapeutics with excellent antitumor activity. |
| doi_str_mv | 10.1039/c8tb02815j |
| format | Article |
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in vitro
and
in vivo
antitumor activity. Taking into account the diversity of MOFs and different functional molecules, this work provides flexible access to programmable MOF nanoparticles for specific biological applications.
Programmable metal-organic frameworks were prepared as efficient delivery vehicles for targeted and stimuli-responsive release of multi-therapeutics with excellent antitumor activity.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c8tb02815j</identifier><identifier>PMID: 32255104</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Anticancer properties ; Antitumor activity ; Cancer ; Drug delivery ; Drug delivery systems ; EGR-1 protein ; Metal-organic frameworks ; Metals ; Nanoparticles ; Stimuli ; Therapy ; Tumors</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2019-02, Vol.7 (6), p.994-14</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-192c7af93c584d2627e002e91f70464c0d56d35f939301c0b294fc01aec6d8083</citedby><cites>FETCH-LOGICAL-c444t-192c7af93c584d2627e002e91f70464c0d56d35f939301c0b294fc01aec6d8083</cites><orcidid>0000-0002-3063-2485 ; 0000-0002-1309-5454</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32255104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Jie</creatorcontrib><creatorcontrib>Xu, Zhen</creatorcontrib><creatorcontrib>Dong, Ping</creatorcontrib><creatorcontrib>Yu, Wenqian</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Jiang, Qunying</creatorcontrib><creatorcontrib>Wang, Fuan</creatorcontrib><creatorcontrib>Liu, Xiaoqing</creatorcontrib><title>Stimuli-responsive multifunctional metal-organic framework nanoparticles for enhanced chemo-photothermal therapy</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Construction of stimuli-responsive multifunctional nanoparticles is critical for nanotherapeutic delivery. Though metal-organic frameworks (MOFs) have been emerged as promising delivery vehicles, the therapeutic efficacy of MOFs in cancer treatment is limited by the lack of a general approach for the preparation of stimuli-responsive multifunctional MOFs. We show that the combination of a versatile coating material polydopamine with MOFs enables facile integration of different functional therapeutics, obtaining stimuli-responsive multifunctional MOFs with extensive photothermal efficiency and outstanding capability to abrogate tumors by chemo-photothermal therapy. Exemplary MOFs including ZIF-8, UiO-66, and MIL-101 were utilized to prepare stimuli-responsive multifunctional MOFs to illustrate the generality of the strategy. This approach enables targeted drug delivery and stimuli-responsive release of multi-therapeutics and allows combination therapy with excellent
in vitro
and
in vivo
antitumor activity. Taking into account the diversity of MOFs and different functional molecules, this work provides flexible access to programmable MOF nanoparticles for specific biological applications.
Programmable metal-organic frameworks were prepared as efficient delivery vehicles for targeted and stimuli-responsive release of multi-therapeutics with excellent antitumor activity.</description><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Cancer</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>EGR-1 protein</subject><subject>Metal-organic frameworks</subject><subject>Metals</subject><subject>Nanoparticles</subject><subject>Stimuli</subject><subject>Therapy</subject><subject>Tumors</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpd0c9LHDEUB_BQlCrqpfeWAS9FGH35NZM56lK1Iniohd6GbOZNN9uZZJpkKv73RteuYC4vIR--j-QR8onCKQXenBmVlsAUlesPZJ-BhLKWVO1s9_BrjxzFuIa8FK0UFx_JHmdMSgpin0w_kh3nwZYB4-RdtP-wyOdk-9mZZL3TQzFi0kPpw2_trCn6oEd88OFP4bTzkw7JmgFj0ftQoFtpZ7ArzApHX04rn3xaYRhzynPV0-Mh2e31EPHotR6Qn5ff7hfX5e3d1ffF-W1phBCppA0zte4bbqQSHatYjQAMG9rXICphoJNVx2UGDQdqYMka0RugGk3VKVD8gHzd5E7B_50xpna00eAwaId-ji3jqmZSUE4zPX5H134O-eVZ0Tq3lpQ1WZ1slAk-xoB9OwU76vDYUmifR9Eu1P3FyyhuMv7yGjkvR-y29P_HZ_B5A0I029u3WfInBu2PEg</recordid><startdate>20190214</startdate><enddate>20190214</enddate><creator>Feng, Jie</creator><creator>Xu, Zhen</creator><creator>Dong, Ping</creator><creator>Yu, Wenqian</creator><creator>Liu, Feng</creator><creator>Jiang, Qunying</creator><creator>Wang, Fuan</creator><creator>Liu, Xiaoqing</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3063-2485</orcidid><orcidid>https://orcid.org/0000-0002-1309-5454</orcidid></search><sort><creationdate>20190214</creationdate><title>Stimuli-responsive multifunctional metal-organic framework nanoparticles for enhanced chemo-photothermal therapy</title><author>Feng, Jie ; Xu, Zhen ; Dong, Ping ; Yu, Wenqian ; Liu, Feng ; Jiang, Qunying ; Wang, Fuan ; Liu, Xiaoqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-192c7af93c584d2627e002e91f70464c0d56d35f939301c0b294fc01aec6d8083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Cancer</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>EGR-1 protein</topic><topic>Metal-organic frameworks</topic><topic>Metals</topic><topic>Nanoparticles</topic><topic>Stimuli</topic><topic>Therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Jie</creatorcontrib><creatorcontrib>Xu, Zhen</creatorcontrib><creatorcontrib>Dong, Ping</creatorcontrib><creatorcontrib>Yu, Wenqian</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Jiang, Qunying</creatorcontrib><creatorcontrib>Wang, Fuan</creatorcontrib><creatorcontrib>Liu, Xiaoqing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Jie</au><au>Xu, Zhen</au><au>Dong, Ping</au><au>Yu, Wenqian</au><au>Liu, Feng</au><au>Jiang, Qunying</au><au>Wang, Fuan</au><au>Liu, Xiaoqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimuli-responsive multifunctional metal-organic framework nanoparticles for enhanced chemo-photothermal therapy</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2019-02-14</date><risdate>2019</risdate><volume>7</volume><issue>6</issue><spage>994</spage><epage>14</epage><pages>994-14</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Construction of stimuli-responsive multifunctional nanoparticles is critical for nanotherapeutic delivery. Though metal-organic frameworks (MOFs) have been emerged as promising delivery vehicles, the therapeutic efficacy of MOFs in cancer treatment is limited by the lack of a general approach for the preparation of stimuli-responsive multifunctional MOFs. We show that the combination of a versatile coating material polydopamine with MOFs enables facile integration of different functional therapeutics, obtaining stimuli-responsive multifunctional MOFs with extensive photothermal efficiency and outstanding capability to abrogate tumors by chemo-photothermal therapy. Exemplary MOFs including ZIF-8, UiO-66, and MIL-101 were utilized to prepare stimuli-responsive multifunctional MOFs to illustrate the generality of the strategy. This approach enables targeted drug delivery and stimuli-responsive release of multi-therapeutics and allows combination therapy with excellent
in vitro
and
in vivo
antitumor activity. Taking into account the diversity of MOFs and different functional molecules, this work provides flexible access to programmable MOF nanoparticles for specific biological applications.
Programmable metal-organic frameworks were prepared as efficient delivery vehicles for targeted and stimuli-responsive release of multi-therapeutics with excellent antitumor activity.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32255104</pmid><doi>10.1039/c8tb02815j</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3063-2485</orcidid><orcidid>https://orcid.org/0000-0002-1309-5454</orcidid></addata></record> |
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| source | Royal Society Of Chemistry Journals |
| subjects | Anticancer properties Antitumor activity Cancer Drug delivery Drug delivery systems EGR-1 protein Metal-organic frameworks Metals Nanoparticles Stimuli Therapy Tumors |
| title | Stimuli-responsive multifunctional metal-organic framework nanoparticles for enhanced chemo-photothermal therapy |
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