Association between FDG uptake in the right ventricular myocardium and cancer therapy-induced cardiotoxicity
The aim of this study was to investigate changes in myocardial uptake evaluated by oncologic 18F-fluorodeoxyglucose (FDG) PET/CT scans and to determine the relationship between myocardial FDG uptake and cancer therapy-induced cardiotoxicity in breast cancer patients who underwent anthracycline or tr...
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| Veröffentlicht in: | Journal of nuclear cardiology 2020-12, Vol.27 (6), p.2154-2163 |
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| creator | Kim, Jahae Cho, Sang-Geon Kang, Sae-Ryung Yoo, Su Woong Kwon, Seong Young Min, Jung-Joon Bom, Hee-Seung Song, Ho-Chun |
| description | The aim of this study was to investigate changes in myocardial uptake evaluated by oncologic 18F-fluorodeoxyglucose (FDG) PET/CT scans and to determine the relationship between myocardial FDG uptake and cancer therapy-induced cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab.
We reviewed 121 consecutive patients who underwent oncologic FDG PET/CT and echocardiography at baseline and post-therapy with anthracyclines or trastuzumab for breast cancer. Grade in LV wall, uptake pattern in LV wall, and the presence of RV wall uptake were assessed by visual analysis, and the mean SUV in the LV and RV walls and the change of SUV (ΔSUV) between baseline and post-therapy PET/CT were measured by quantitative analysis. Multiple logistic regression analyses were performed to evaluate the association between PET parameters and cardiotoxicity.
Fifteen patients (12%) showed cardiotoxicity after therapy. The cardiotoxic group tended to show more diffuse LV uptake, higher SUV, and ΔSUV of RV wall than the non-cardiotoxic group following therapy with anthracyclines or trastuzumab. Logistic regression analysis showed that the presence of RV wall uptake, SUV of RV wall (> 1.8), and ΔSUV of RV wall (> 0.4) were significantly associated with cardiotoxicity after controlling for age, radiotherapy, and treatment.
The presence of RV wall uptake and the increase of SUV of RV wall on post-therapy PET/CT were associated with cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab. Oncologic FDG PET/CT scans can provide information regarding cancer therapy-induced cardiotoxicity as well as tumor response. |
| doi_str_mv | 10.1007/s12350-019-01617-y |
| format | Article |
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We reviewed 121 consecutive patients who underwent oncologic FDG PET/CT and echocardiography at baseline and post-therapy with anthracyclines or trastuzumab for breast cancer. Grade in LV wall, uptake pattern in LV wall, and the presence of RV wall uptake were assessed by visual analysis, and the mean SUV in the LV and RV walls and the change of SUV (ΔSUV) between baseline and post-therapy PET/CT were measured by quantitative analysis. Multiple logistic regression analyses were performed to evaluate the association between PET parameters and cardiotoxicity.
Fifteen patients (12%) showed cardiotoxicity after therapy. The cardiotoxic group tended to show more diffuse LV uptake, higher SUV, and ΔSUV of RV wall than the non-cardiotoxic group following therapy with anthracyclines or trastuzumab. Logistic regression analysis showed that the presence of RV wall uptake, SUV of RV wall (> 1.8), and ΔSUV of RV wall (> 0.4) were significantly associated with cardiotoxicity after controlling for age, radiotherapy, and treatment.
The presence of RV wall uptake and the increase of SUV of RV wall on post-therapy PET/CT were associated with cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab. Oncologic FDG PET/CT scans can provide information regarding cancer therapy-induced cardiotoxicity as well as tumor response.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-019-01617-y</identifier><identifier>PMID: 30719656</identifier><language>eng</language><publisher>Cham: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anthracyclines - administration & dosage ; Breast cancer ; Breast Neoplasms - complications ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - drug therapy ; Cancer therapies ; Cardiology ; Cardiotoxicity ; Diagnostic and prognostic application ; Echocardiography ; Female ; Fluorodeoxyglucose F18 ; Heart Ventricles - diagnostic imaging ; Humans ; image interpretation ; Imaging ; Male ; Medical diagnosis ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Monoclonal antibodies ; Nuclear Medicine ; Original Article ; PET ; Positron Emission Tomography Computed Tomography - methods ; Radiology ; Regression Analysis ; ROC Curve ; Sensitivity and Specificity ; Targeted cancer therapy ; Trastuzumab - administration & dosage ; Ventricular Dysfunction, Right - diagnostic imaging</subject><ispartof>Journal of nuclear cardiology, 2020-12, Vol.27 (6), p.2154-2163</ispartof><rights>2020 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved.</rights><rights>American Society of Nuclear Cardiology 2019</rights><rights>Journal of Nuclear Cardiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-f74018ab3d99fe2d4888cb1b2ba87c0693ca6e10597264d2a5210d8859971f9e3</citedby><cites>FETCH-LOGICAL-c538t-f74018ab3d99fe2d4888cb1b2ba87c0693ca6e10597264d2a5210d8859971f9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-019-01617-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-019-01617-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30719656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jahae</creatorcontrib><creatorcontrib>Cho, Sang-Geon</creatorcontrib><creatorcontrib>Kang, Sae-Ryung</creatorcontrib><creatorcontrib>Yoo, Su Woong</creatorcontrib><creatorcontrib>Kwon, Seong Young</creatorcontrib><creatorcontrib>Min, Jung-Joon</creatorcontrib><creatorcontrib>Bom, Hee-Seung</creatorcontrib><creatorcontrib>Song, Ho-Chun</creatorcontrib><title>Association between FDG uptake in the right ventricular myocardium and cancer therapy-induced cardiotoxicity</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>The aim of this study was to investigate changes in myocardial uptake evaluated by oncologic 18F-fluorodeoxyglucose (FDG) PET/CT scans and to determine the relationship between myocardial FDG uptake and cancer therapy-induced cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab.
We reviewed 121 consecutive patients who underwent oncologic FDG PET/CT and echocardiography at baseline and post-therapy with anthracyclines or trastuzumab for breast cancer. Grade in LV wall, uptake pattern in LV wall, and the presence of RV wall uptake were assessed by visual analysis, and the mean SUV in the LV and RV walls and the change of SUV (ΔSUV) between baseline and post-therapy PET/CT were measured by quantitative analysis. Multiple logistic regression analyses were performed to evaluate the association between PET parameters and cardiotoxicity.
Fifteen patients (12%) showed cardiotoxicity after therapy. The cardiotoxic group tended to show more diffuse LV uptake, higher SUV, and ΔSUV of RV wall than the non-cardiotoxic group following therapy with anthracyclines or trastuzumab. Logistic regression analysis showed that the presence of RV wall uptake, SUV of RV wall (> 1.8), and ΔSUV of RV wall (> 0.4) were significantly associated with cardiotoxicity after controlling for age, radiotherapy, and treatment.
The presence of RV wall uptake and the increase of SUV of RV wall on post-therapy PET/CT were associated with cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab. Oncologic FDG PET/CT scans can provide information regarding cancer therapy-induced cardiotoxicity as well as tumor response.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anthracyclines - administration & dosage</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Cancer therapies</subject><subject>Cardiology</subject><subject>Cardiotoxicity</subject><subject>Diagnostic and prognostic application</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Humans</subject><subject>image interpretation</subject><subject>Imaging</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>PET</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Radiology</subject><subject>Regression Analysis</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Targeted cancer therapy</subject><subject>Trastuzumab - administration & dosage</subject><subject>Ventricular Dysfunction, Right - diagnostic imaging</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFuFSEUhonR2Fp9AReGxPVUDlwGSNw01VaTJm50TRg401LvHa7AtM7by-1U3XVBIJzv_0_yEfIW2Ckwpj4U4EKyjoFppwfVLc_IMUjBu15KeN7eTEEnpIYj8qqUW8aYEca8JEeiDUwv-2OyPSsl-ehqTBMdsN4jTvTi0yWd99X9RBonWm-Q5nh9U-kdTjVHP29dprsleZdDnHfUTYF6N3nMBza7_dLFKcweD98NSTX9jj7W5TV5MbptwTeP9wn5cfH5-_mX7urb5dfzs6vOS6FrN6oNA-0GEYwZkYeN1toPMPDBaeVZb4R3PQKTRvF-E7iTHFjQWhqjYDQoTsj7tXef068ZS7W3ac5TW2k5KKlgAwYaxVfK51RKxtHuc9y5vFhg9iDYroJtE2wfBNulhd49Vs_DDsO_yF-jDRArUNpousb8f_eTtR_XFDYtd7Glio_YlIaY0VcbUnwq_gcNNpt0</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Kim, Jahae</creator><creator>Cho, Sang-Geon</creator><creator>Kang, Sae-Ryung</creator><creator>Yoo, Su Woong</creator><creator>Kwon, Seong Young</creator><creator>Min, Jung-Joon</creator><creator>Bom, Hee-Seung</creator><creator>Song, Ho-Chun</creator><general>Elsevier Inc</general><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20201201</creationdate><title>Association between FDG uptake in the right ventricular myocardium and cancer therapy-induced cardiotoxicity</title><author>Kim, Jahae ; Cho, Sang-Geon ; Kang, Sae-Ryung ; Yoo, Su Woong ; Kwon, Seong Young ; Min, Jung-Joon ; Bom, Hee-Seung ; Song, Ho-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-f74018ab3d99fe2d4888cb1b2ba87c0693ca6e10597264d2a5210d8859971f9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anthracyclines - administration & dosage</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Cancer therapies</topic><topic>Cardiology</topic><topic>Cardiotoxicity</topic><topic>Diagnostic and prognostic application</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Humans</topic><topic>image interpretation</topic><topic>Imaging</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>PET</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Radiology</topic><topic>Regression Analysis</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Targeted cancer therapy</topic><topic>Trastuzumab - administration & dosage</topic><topic>Ventricular Dysfunction, Right - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jahae</creatorcontrib><creatorcontrib>Cho, Sang-Geon</creatorcontrib><creatorcontrib>Kang, Sae-Ryung</creatorcontrib><creatorcontrib>Yoo, Su Woong</creatorcontrib><creatorcontrib>Kwon, Seong Young</creatorcontrib><creatorcontrib>Min, Jung-Joon</creatorcontrib><creatorcontrib>Bom, Hee-Seung</creatorcontrib><creatorcontrib>Song, Ho-Chun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jahae</au><au>Cho, Sang-Geon</au><au>Kang, Sae-Ryung</au><au>Yoo, Su Woong</au><au>Kwon, Seong Young</au><au>Min, Jung-Joon</au><au>Bom, Hee-Seung</au><au>Song, Ho-Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between FDG uptake in the right ventricular myocardium and cancer therapy-induced cardiotoxicity</atitle><jtitle>Journal of nuclear cardiology</jtitle><stitle>J. Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>27</volume><issue>6</issue><spage>2154</spage><epage>2163</epage><pages>2154-2163</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>The aim of this study was to investigate changes in myocardial uptake evaluated by oncologic 18F-fluorodeoxyglucose (FDG) PET/CT scans and to determine the relationship between myocardial FDG uptake and cancer therapy-induced cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab.
We reviewed 121 consecutive patients who underwent oncologic FDG PET/CT and echocardiography at baseline and post-therapy with anthracyclines or trastuzumab for breast cancer. Grade in LV wall, uptake pattern in LV wall, and the presence of RV wall uptake were assessed by visual analysis, and the mean SUV in the LV and RV walls and the change of SUV (ΔSUV) between baseline and post-therapy PET/CT were measured by quantitative analysis. Multiple logistic regression analyses were performed to evaluate the association between PET parameters and cardiotoxicity.
Fifteen patients (12%) showed cardiotoxicity after therapy. The cardiotoxic group tended to show more diffuse LV uptake, higher SUV, and ΔSUV of RV wall than the non-cardiotoxic group following therapy with anthracyclines or trastuzumab. Logistic regression analysis showed that the presence of RV wall uptake, SUV of RV wall (> 1.8), and ΔSUV of RV wall (> 0.4) were significantly associated with cardiotoxicity after controlling for age, radiotherapy, and treatment.
The presence of RV wall uptake and the increase of SUV of RV wall on post-therapy PET/CT were associated with cardiotoxicity in breast cancer patients who underwent anthracycline or trastuzumab. Oncologic FDG PET/CT scans can provide information regarding cancer therapy-induced cardiotoxicity as well as tumor response.</abstract><cop>Cham</cop><pub>Elsevier Inc</pub><pmid>30719656</pmid><doi>10.1007/s12350-019-01617-y</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Anthracyclines - administration & dosage Breast cancer Breast Neoplasms - complications Breast Neoplasms - diagnostic imaging Breast Neoplasms - drug therapy Cancer therapies Cardiology Cardiotoxicity Diagnostic and prognostic application Echocardiography Female Fluorodeoxyglucose F18 Heart Ventricles - diagnostic imaging Humans image interpretation Imaging Male Medical diagnosis Medical imaging Medicine Medicine & Public Health Middle Aged Monoclonal antibodies Nuclear Medicine Original Article PET Positron Emission Tomography Computed Tomography - methods Radiology Regression Analysis ROC Curve Sensitivity and Specificity Targeted cancer therapy Trastuzumab - administration & dosage Ventricular Dysfunction, Right - diagnostic imaging |
| title | Association between FDG uptake in the right ventricular myocardium and cancer therapy-induced cardiotoxicity |
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