Characterization of a non‐thermally operated electrosurgical argon plasma source by electron spin resonance spectroscopy
Non‐thermal plasma treatment is one of the promising options for local anti‐neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Primarily, the antiproliferative properties are driven through the generation of reactive oxygen and nitrogen species. In this study, we investigat...
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| Veröffentlicht in: | Plasma processes and polymers 2019-02, Vol.16 (2), p.n/a |
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| container_title | Plasma processes and polymers |
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| creator | Weiss, Martin Utz, Raphael Ackermann, Michael Taran, Florin‐Andrei Krämer, Bernhard Hahn, Markus Wallwiener, Diethelm Brucker, Sara Haupt, Michael Barz, Jakob Oehr, Christian |
| description | Non‐thermal plasma treatment is one of the promising options for local anti‐neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Primarily, the antiproliferative properties are driven through the generation of reactive oxygen and nitrogen species. In this study, we investigated the amount and distribution of reactive species generated by a non‐thermally operated electrosurgical argon plasma source using electron spin resonance (ESR) spectroscopy. During the plasma treatment of both, aqueous solution and solid human preputial tissue an increasing amount of different oxygen‐ and carbon‐centered radicals was detected. However, and most probably due to spin trap degradation by the high energy input and the increase of reactive components in aqueous solution, the ESR signal decreased after treatment times exceeding 10 s.
Non‐thermally operated electrosurgical argon plasma sources reveal a potent emergence of reactive species and may be suitable for usual cold atmospheric plasma applications in plasma medicine. The vigorous generation of reactive plasma components of these plasma sources, being the main trigger for plasma related cell phenomena, may enable efficient treatment of precancerous and cancerous lesions. |
| doi_str_mv | 10.1002/ppap.201800150 |
| format | Article |
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Non‐thermally operated electrosurgical argon plasma sources reveal a potent emergence of reactive species and may be suitable for usual cold atmospheric plasma applications in plasma medicine. The vigorous generation of reactive plasma components of these plasma sources, being the main trigger for plasma related cell phenomena, may enable efficient treatment of precancerous and cancerous lesions.</description><identifier>ISSN: 1612-8850</identifier><identifier>EISSN: 1612-8869</identifier><identifier>DOI: 10.1002/ppap.201800150</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Aqueous solutions ; Argon ; Argon plasma ; Electron paramagnetic resonance ; Electron spin ; electron spin resonance spectroscopy (ESR) ; Electrons ; free radicals ; Heat treatment ; high‐frequency electrosurgery ; Lesions ; non‐thermal plasma ; Plasma ; plasma treatment ; Spectroscopy ; Spectrum analysis ; Spin resonance ; Thermal plasmas</subject><ispartof>Plasma processes and polymers, 2019-02, Vol.16 (2), p.n/a</ispartof><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3170-7d6f9368a4010698f781b427ba897f1df8dff2a7cbdecbbf25825b9d924276733</citedby><cites>FETCH-LOGICAL-c3170-7d6f9368a4010698f781b427ba897f1df8dff2a7cbdecbbf25825b9d924276733</cites><orcidid>0000-0001-8511-8339</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppap.201800150$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppap.201800150$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Weiss, Martin</creatorcontrib><creatorcontrib>Utz, Raphael</creatorcontrib><creatorcontrib>Ackermann, Michael</creatorcontrib><creatorcontrib>Taran, Florin‐Andrei</creatorcontrib><creatorcontrib>Krämer, Bernhard</creatorcontrib><creatorcontrib>Hahn, Markus</creatorcontrib><creatorcontrib>Wallwiener, Diethelm</creatorcontrib><creatorcontrib>Brucker, Sara</creatorcontrib><creatorcontrib>Haupt, Michael</creatorcontrib><creatorcontrib>Barz, Jakob</creatorcontrib><creatorcontrib>Oehr, Christian</creatorcontrib><title>Characterization of a non‐thermally operated electrosurgical argon plasma source by electron spin resonance spectroscopy</title><title>Plasma processes and polymers</title><description>Non‐thermal plasma treatment is one of the promising options for local anti‐neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Primarily, the antiproliferative properties are driven through the generation of reactive oxygen and nitrogen species. In this study, we investigated the amount and distribution of reactive species generated by a non‐thermally operated electrosurgical argon plasma source using electron spin resonance (ESR) spectroscopy. During the plasma treatment of both, aqueous solution and solid human preputial tissue an increasing amount of different oxygen‐ and carbon‐centered radicals was detected. However, and most probably due to spin trap degradation by the high energy input and the increase of reactive components in aqueous solution, the ESR signal decreased after treatment times exceeding 10 s.
Non‐thermally operated electrosurgical argon plasma sources reveal a potent emergence of reactive species and may be suitable for usual cold atmospheric plasma applications in plasma medicine. The vigorous generation of reactive plasma components of these plasma sources, being the main trigger for plasma related cell phenomena, may enable efficient treatment of precancerous and cancerous lesions.</description><subject>Aqueous solutions</subject><subject>Argon</subject><subject>Argon plasma</subject><subject>Electron paramagnetic resonance</subject><subject>Electron spin</subject><subject>electron spin resonance spectroscopy (ESR)</subject><subject>Electrons</subject><subject>free radicals</subject><subject>Heat treatment</subject><subject>high‐frequency electrosurgery</subject><subject>Lesions</subject><subject>non‐thermal plasma</subject><subject>Plasma</subject><subject>plasma treatment</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Spin resonance</subject><subject>Thermal plasmas</subject><issn>1612-8850</issn><issn>1612-8869</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkL9OwzAQhy0EEqWwMltiTjk7TeyMVcU_qRIdYI4ujt2mSmNjp0LpxCPwjDwJqQJlZLqT7vvuTj9CrhlMGAC_dQ7dhAOTACyBEzJiKeORlGl2euwTOCcXIWwAYkgkjMh-vkaPqtW-2mNb2YZaQ5E2tvn6-GzX2m-xrjtqnfbY6pLqWqvW27Dzq0phTdGvesfVGLZIg915pWnR_WINDa5qqNfBNtj0o-AGXVnXXZIzg3XQVz91TF7v717mj9Hi-eFpPltEKmYCIlGmJotTiVNgkGbSCMmKKRcFykwYVhpZGsNRqKLUqigMTyRPiqzMeA-lIo7H5GbY67x92-nQ5pv-z6Y_mXMmEp6INIWemgyU6t8LXpvc-WqLvssZ5Id880O--THfXsgG4b2qdfcPnS-Xs-Wf-w1t6INi</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Weiss, Martin</creator><creator>Utz, Raphael</creator><creator>Ackermann, Michael</creator><creator>Taran, Florin‐Andrei</creator><creator>Krämer, Bernhard</creator><creator>Hahn, Markus</creator><creator>Wallwiener, Diethelm</creator><creator>Brucker, Sara</creator><creator>Haupt, Michael</creator><creator>Barz, Jakob</creator><creator>Oehr, Christian</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-8511-8339</orcidid></search><sort><creationdate>201902</creationdate><title>Characterization of a non‐thermally operated electrosurgical argon plasma source by electron spin resonance spectroscopy</title><author>Weiss, Martin ; Utz, Raphael ; Ackermann, Michael ; Taran, Florin‐Andrei ; Krämer, Bernhard ; Hahn, Markus ; Wallwiener, Diethelm ; Brucker, Sara ; Haupt, Michael ; Barz, Jakob ; Oehr, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3170-7d6f9368a4010698f781b427ba897f1df8dff2a7cbdecbbf25825b9d924276733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aqueous solutions</topic><topic>Argon</topic><topic>Argon plasma</topic><topic>Electron paramagnetic resonance</topic><topic>Electron spin</topic><topic>electron spin resonance spectroscopy (ESR)</topic><topic>Electrons</topic><topic>free radicals</topic><topic>Heat treatment</topic><topic>high‐frequency electrosurgery</topic><topic>Lesions</topic><topic>non‐thermal plasma</topic><topic>Plasma</topic><topic>plasma treatment</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Spin resonance</topic><topic>Thermal plasmas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiss, Martin</creatorcontrib><creatorcontrib>Utz, Raphael</creatorcontrib><creatorcontrib>Ackermann, Michael</creatorcontrib><creatorcontrib>Taran, Florin‐Andrei</creatorcontrib><creatorcontrib>Krämer, Bernhard</creatorcontrib><creatorcontrib>Hahn, Markus</creatorcontrib><creatorcontrib>Wallwiener, Diethelm</creatorcontrib><creatorcontrib>Brucker, Sara</creatorcontrib><creatorcontrib>Haupt, Michael</creatorcontrib><creatorcontrib>Barz, Jakob</creatorcontrib><creatorcontrib>Oehr, Christian</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Plasma processes and polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiss, Martin</au><au>Utz, Raphael</au><au>Ackermann, Michael</au><au>Taran, Florin‐Andrei</au><au>Krämer, Bernhard</au><au>Hahn, Markus</au><au>Wallwiener, Diethelm</au><au>Brucker, Sara</au><au>Haupt, Michael</au><au>Barz, Jakob</au><au>Oehr, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of a non‐thermally operated electrosurgical argon plasma source by electron spin resonance spectroscopy</atitle><jtitle>Plasma processes and polymers</jtitle><date>2019-02</date><risdate>2019</risdate><volume>16</volume><issue>2</issue><epage>n/a</epage><issn>1612-8850</issn><eissn>1612-8869</eissn><abstract>Non‐thermal plasma treatment is one of the promising options for local anti‐neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Primarily, the antiproliferative properties are driven through the generation of reactive oxygen and nitrogen species. In this study, we investigated the amount and distribution of reactive species generated by a non‐thermally operated electrosurgical argon plasma source using electron spin resonance (ESR) spectroscopy. During the plasma treatment of both, aqueous solution and solid human preputial tissue an increasing amount of different oxygen‐ and carbon‐centered radicals was detected. However, and most probably due to spin trap degradation by the high energy input and the increase of reactive components in aqueous solution, the ESR signal decreased after treatment times exceeding 10 s.
Non‐thermally operated electrosurgical argon plasma sources reveal a potent emergence of reactive species and may be suitable for usual cold atmospheric plasma applications in plasma medicine. The vigorous generation of reactive plasma components of these plasma sources, being the main trigger for plasma related cell phenomena, may enable efficient treatment of precancerous and cancerous lesions.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ppap.201800150</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8511-8339</orcidid></addata></record> |
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| subjects | Aqueous solutions Argon Argon plasma Electron paramagnetic resonance Electron spin electron spin resonance spectroscopy (ESR) Electrons free radicals Heat treatment high‐frequency electrosurgery Lesions non‐thermal plasma Plasma plasma treatment Spectroscopy Spectrum analysis Spin resonance Thermal plasmas |
| title | Characterization of a non‐thermally operated electrosurgical argon plasma source by electron spin resonance spectroscopy |
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