Novel Biochemical Pathways for 5-Fluorouracil in Managing Experimental Hepatocellular Carcinoma in Rats

Five fluorouracil (5-FU) is extensively used in the treatment of hepatocellular carcinoma (HCC). It is well documented that 5-FU and its metabolites inhibit DNA synthesis through inhibition of thymidylate synthetase. Little is known about additional pathways for 5-FU in managing HCC. The present exp...

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Veröffentlicht in:	The Journal of membrane biology 2010-03, Vol.234 (1), p.29-34
Hauptverfasser:	Abdel-Hamid, Nabil M, Morsy, Mohamed A
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - metabolism Animals Biochemistry Biomedical and Life Sciences Cancer Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cellular biology Enzymes Fluorouracil - pharmacology Fluorouracil - therapeutic use Glucosamine - metabolism Glycosaminoglycans - metabolism Human Physiology Life Sciences Liver - metabolism Liver cancer Liver Neoplasms, Experimental - drug therapy Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Male Metastasis N-Acetylneuraminic Acid - metabolism Rats Rats, Wistar Trichloroacetic Acid
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