Recent Developments in Transition Metal‐Catalyzed Dearomative Cyclizations of Indoles as Dipolarophiles for the Construction of Indolines

Fused polycyclic indoline skeletons are found in many natural products and bioactive molecules. Several approaches, including dearomative cyclization of functionalized indoles, have been developed for the rapid synthesis of these skeletons. As a result of extensive research over the past few decades...

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Veröffentlicht in:	Advanced synthesis & catalysis 2019-02, Vol.361 (3), p.405-425
Hauptverfasser:	Huang, Guanghao, Yin, Biaolin
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Sprache:	eng
Schlagworte:	dearomative cyclization fused indolines Heterocyclic compounds Indoles Natural products ring contraction synthetic methods transition metal catalysis Transition metals
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container_title	Advanced synthesis & catalysis
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creator	Huang, Guanghao Yin, Biaolin
description	Fused polycyclic indoline skeletons are found in many natural products and bioactive molecules. Several approaches, including dearomative cyclization of functionalized indoles, have been developed for the rapid synthesis of these skeletons. As a result of extensive research over the past few decades, numerous elegant and efficient protocols for the transition metal‐catalyzed dearomative cyclization of indoles to afford indolines have been reported, and recent developments in this area are discussed in detail in this review.
doi_str_mv	10.1002/adsc.201800789
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subjects	dearomative cyclization fused indolines Heterocyclic compounds Indoles Natural products ring contraction synthetic methods transition metal catalysis Transition metals
title	Recent Developments in Transition Metal‐Catalyzed Dearomative Cyclizations of Indoles as Dipolarophiles for the Construction of Indolines
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