Determination of antimicrobial and antiviral properties of IR3535
Insect repellent is a substance directly applied to skin or clothing in order to repel flies, mosquitoes, ticks etc. IR3535 or Ethyl butylacetylaminopropionate (EBAAP) is a relatively new repellent which is classified as a biopesticide due to exceptional skin tolerance and overall safety. The repell...
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| Veröffentlicht in: | Molecular biology reports 2019-04, Vol.46 (2), p.1819-1824 |
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| creator | Iyigundogdu, Zeynep Kalayci, Sadik Asutay, Ayla Burcin Sahin, Fikrettin |
| description | Insect repellent is a substance directly applied to skin or clothing in order to repel flies, mosquitoes, ticks etc. IR3535 or Ethyl butylacetylaminopropionate (EBAAP) is a relatively new repellent which is classified as a biopesticide due to exceptional skin tolerance and overall safety. The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged. However, there has been no attempt to investigate the effects on microorganisms or viruses up to now. In the present study, antimicrobial activity was investigated based on disc diffusion and micro-well dilution assays. Disc diffusion assays revealed IR3535 displayed remarkable antimicrobial activity on the microorganisms tested. MIC results showed that the antifungal efficiency of IR3535 is higher with respect to its antibacterial and anticandidal efficiency. Moreover, antiviral test results revealed that IR3535 showed antiviral effects against Poliovirus and Adenovirus. This is the first study that reveals IR3535’s antimicrobial and antiviral properties against a broad range of microorganisms and viruses. In consideration of the antimicrobial and antiviral properties, IR3535 is a promising agent that could be used to develop novel therapeutic approaches, new application areas and formulations in the future. |
| doi_str_mv | 10.1007/s11033-019-04632-x |
| format | Article |
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The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged. However, there has been no attempt to investigate the effects on microorganisms or viruses up to now. In the present study, antimicrobial activity was investigated based on disc diffusion and micro-well dilution assays. Disc diffusion assays revealed IR3535 displayed remarkable antimicrobial activity on the microorganisms tested. MIC results showed that the antifungal efficiency of IR3535 is higher with respect to its antibacterial and anticandidal efficiency. Moreover, antiviral test results revealed that IR3535 showed antiviral effects against Poliovirus and Adenovirus. This is the first study that reveals IR3535’s antimicrobial and antiviral properties against a broad range of microorganisms and viruses. In consideration of the antimicrobial and antiviral properties, IR3535 is a promising agent that could be used to develop novel therapeutic approaches, new application areas and formulations in the future.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-019-04632-x</identifier><identifier>PMID: 30701459</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Anti-Bacterial Agents ; Anti-Infective Agents ; Antimicrobial activity ; Antimicrobial agents ; Antiviral activity ; Antiviral Agents ; Biomedical and Life Sciences ; Histology ; Insect Repellents - chemistry ; Insect Repellents - pharmacology ; Life Sciences ; Microbial Sensitivity Tests - methods ; Microorganisms ; Minimum inhibitory concentration ; Morphology ; Original Article ; Propionates - chemistry ; Propionates - pharmacology ; Repellency ; Skin ; Time Factors ; Toxicity</subject><ispartof>Molecular biology reports, 2019-04, Vol.46 (2), p.1819-1824</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Molecular Biology Reports is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-591f8dc648b2eee32477ec9ac8d03ed27ef7c201ec6d89a919265dd9de2ca21c3</citedby><cites>FETCH-LOGICAL-c375t-591f8dc648b2eee32477ec9ac8d03ed27ef7c201ec6d89a919265dd9de2ca21c3</cites><orcidid>0000-0003-2067-4822</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-019-04632-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-019-04632-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30701459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iyigundogdu, Zeynep</creatorcontrib><creatorcontrib>Kalayci, Sadik</creatorcontrib><creatorcontrib>Asutay, Ayla Burcin</creatorcontrib><creatorcontrib>Sahin, Fikrettin</creatorcontrib><title>Determination of antimicrobial and antiviral properties of IR3535</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Insect repellent is a substance directly applied to skin or clothing in order to repel flies, mosquitoes, ticks etc. IR3535 or Ethyl butylacetylaminopropionate (EBAAP) is a relatively new repellent which is classified as a biopesticide due to exceptional skin tolerance and overall safety. The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged. However, there has been no attempt to investigate the effects on microorganisms or viruses up to now. In the present study, antimicrobial activity was investigated based on disc diffusion and micro-well dilution assays. Disc diffusion assays revealed IR3535 displayed remarkable antimicrobial activity on the microorganisms tested. MIC results showed that the antifungal efficiency of IR3535 is higher with respect to its antibacterial and anticandidal efficiency. Moreover, antiviral test results revealed that IR3535 showed antiviral effects against Poliovirus and Adenovirus. This is the first study that reveals IR3535’s antimicrobial and antiviral properties against a broad range of microorganisms and viruses. In consideration of the antimicrobial and antiviral properties, IR3535 is a promising agent that could be used to develop novel therapeutic approaches, new application areas and formulations in the future.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Anti-Bacterial Agents</subject><subject>Anti-Infective Agents</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Antiviral activity</subject><subject>Antiviral Agents</subject><subject>Biomedical and Life Sciences</subject><subject>Histology</subject><subject>Insect Repellents - chemistry</subject><subject>Insect Repellents - pharmacology</subject><subject>Life Sciences</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Microorganisms</subject><subject>Minimum inhibitory concentration</subject><subject>Morphology</subject><subject>Original Article</subject><subject>Propionates - chemistry</subject><subject>Propionates - pharmacology</subject><subject>Repellency</subject><subject>Skin</subject><subject>Time Factors</subject><subject>Toxicity</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAcpeI5mks1mcyz1q1AQRM9hm8xKSne3Jlup_960W_XmKUzyzDuTh5BLYDfAmLqNAEwIykBTluWC0-0RGYJUgmZaFcdkyAQDmhUSBuQsxiVjLAMlT8lAMMUgk3pIJnfYYah9U3a-bcZtNS6bztfehnbhy1Wq3P7m04dUrUO7xtB5jDty9iKkkOfkpCpXES8O54i8Pdy_Tp_o_PlxNp3MqRVKdlRqqApn86xYcEQUPFMKrS5t4ZhAxxVWynIGaHNX6FKD5rl0TjvktuRgxYhc97lpiY8Nxs4s201o0kjDQQmuskJDonhPpQ_EGLAy6-DrMnwZYGZnzfTWTLJm9tbMNjVdHaI3ixrdb8uPpgSIHojpqXnH8Df7n9hvQoV31w</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Iyigundogdu, Zeynep</creator><creator>Kalayci, Sadik</creator><creator>Asutay, Ayla Burcin</creator><creator>Sahin, Fikrettin</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0003-2067-4822</orcidid></search><sort><creationdate>20190401</creationdate><title>Determination of antimicrobial and antiviral properties of IR3535</title><author>Iyigundogdu, Zeynep ; 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The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged. However, there has been no attempt to investigate the effects on microorganisms or viruses up to now. In the present study, antimicrobial activity was investigated based on disc diffusion and micro-well dilution assays. Disc diffusion assays revealed IR3535 displayed remarkable antimicrobial activity on the microorganisms tested. MIC results showed that the antifungal efficiency of IR3535 is higher with respect to its antibacterial and anticandidal efficiency. Moreover, antiviral test results revealed that IR3535 showed antiviral effects against Poliovirus and Adenovirus. This is the first study that reveals IR3535’s antimicrobial and antiviral properties against a broad range of microorganisms and viruses. In consideration of the antimicrobial and antiviral properties, IR3535 is a promising agent that could be used to develop novel therapeutic approaches, new application areas and formulations in the future.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30701459</pmid><doi>10.1007/s11033-019-04632-x</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2067-4822</orcidid></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Anti-Bacterial Agents Anti-Infective Agents Antimicrobial activity Antimicrobial agents Antiviral activity Antiviral Agents Biomedical and Life Sciences Histology Insect Repellents - chemistry Insect Repellents - pharmacology Life Sciences Microbial Sensitivity Tests - methods Microorganisms Minimum inhibitory concentration Morphology Original Article Propionates - chemistry Propionates - pharmacology Repellency Skin Time Factors Toxicity |
| title | Determination of antimicrobial and antiviral properties of IR3535 |
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