The influence of drug properties and host factors on delayed onset of symptoms in drug‐induced liver injury

Background & Aims Most patients with drug‐induced liver injury (DILI) manifest clinical symptoms while on therapy, while some patients manifest days or weeks after drug cessation (delayed onset). This challenges DILI causality assessment and diagnosis. Factors contributing to the delayed onset p...

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Veröffentlicht in:	Liver international 2019-02, Vol.39 (2), p.401-410
Hauptverfasser:	Gonzalez‐Jimenez, Andres, McEuen, Kristin, Chen, Minjun, Suzuki, Ayako, Robles‐Diaz, Mercedes, Medina‐Caliz, Inmaculada, Bessone, Fernando, Hernandez, Nelia, Arrese, Marco, Parana, Raymundo, Lucena, M. Isabel, Stephens, Camilla, Andrade, Raúl J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Chemical and Drug Induced Liver Injury - etiology Confidence intervals Coronary artery disease Data Mining Diagnostic systems Drug Interactions Drugs Electronegativity Female Heart diseases hepatotoxicity Humans Inflammation interactions Internationality Liability Liver Male Metabolism Middle Aged Mitochondria Multivariate Analysis Patients Phenotype Phenotypes Properties (attributes) Registries Regression analysis Regression models Risk Factors Severity of Illness Index Signs and symptoms Statistical analysis
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