Effects of Olive Leaf Extract on Myoclonic and Tonico-Clonic Seizures in Mice

Effects of a hydroalcoholic olive leaf extract (OLE) on pentylenetetrazol (PTZ, 80 mg/kg)-induced seizures in mice were examined. As was found, the OLE significantly increased the delay of PTZinitiated myoclonic seizures when injected i.p. in a dose of 1000 mg/kg and also significantly delayed the i...

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Veröffentlicht in:	Neurophysiology (New York) 2018-10, Vol.50 (5), p.378-381
Hauptverfasser:	Shahabi, R., Ramezani, F., Nasirinezhad, F., Shahabi, B., Rostampour, M.
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Sprache:	eng
Schlagworte:	Analysis Biomedical and Life Sciences Biomedicine Convulsions & seizures Health aspects Herbal medicine Leaves Myoclonus Neurosciences Seizures
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creator	Shahabi, R. Ramezani, F. Nasirinezhad, F. Shahabi, B. Rostampour, M.
description	Effects of a hydroalcoholic olive leaf extract (OLE) on pentylenetetrazol (PTZ, 80 mg/kg)-induced seizures in mice were examined. As was found, the OLE significantly increased the delay of PTZinitiated myoclonic seizures when injected i.p. in a dose of 1000 mg/kg and also significantly delayed the initiation of tonico-clonic seizures in doses from 250 to 1000 mg/kg. The effects of the OLE on clonico-tonic seizures were more intense than those on myoclonic seizures. The OLE also significantly reduced the mortality rate within a 24-h observation period after PTZ injections. At 125 and 1000 mg/kg doses, 2 and 7 animals of 8 individuals in the OLE-treated groups survived, while all 8 mice died during 24 h in the control group.
doi_str_mv	10.1007/s11062-019-09765-0
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As was found, the OLE significantly increased the delay of PTZinitiated myoclonic seizures when injected i.p. in a dose of 1000 mg/kg and also significantly delayed the initiation of tonico-clonic seizures in doses from 250 to 1000 mg/kg. The effects of the OLE on clonico-tonic seizures were more intense than those on myoclonic seizures. The OLE also significantly reduced the mortality rate within a 24-h observation period after PTZ injections. 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subjects	Analysis Biomedical and Life Sciences Biomedicine Convulsions & seizures Health aspects Herbal medicine Leaves Myoclonus Neurosciences Seizures
title	Effects of Olive Leaf Extract on Myoclonic and Tonico-Clonic Seizures in Mice
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